Modeling the Process of Nicotine Addiction among Youths and Young Adults and Its Potential Future Consequences

模拟青少年尼古丁成瘾过程及其未来的潜在后果

• 批准号: 10666146
• 负责人: David Mendez Emilien
• 金额: $ 44.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-14 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666146
• 关键词: Addictive Behavior; Address; Adolescent; Adolescent and Young Adult; Adult; Affect; Affective; Age; Agreement; Behavior; Biological; Biological Factors; Brain; Cessation of life; Data; Decision Making; Demographic Factors; Education; Electronic Nicotine Delivery Systems; Electronic cigarette; Ensure; Environmental Risk Factor; Future; Gender; Health; Human; Individual; Intention; Literature; Location; Long-Term Effects; Longitudinal Studies; Marketing; Modeling; National Longitudinal Survey of Adolescent to Adult Health; Neurosciences; Nicotine; Nicotine Dependence; Pathway interactions; Policies; Population; Population Analysis; Population Assessment of Tobacco and Health; Prevention; Process; Public Health; Publishing; Race; Regulation; Secure; Smoking; Social Environment; Social Network; Socioeconomic Status; Source; Structure; Surveys; Tobacco; Tobacco use; United States Food and Drug Administration; Youth; addiction; combustible tobacco; demographics; design; experimental study; next generation; nicotine use; novel; premature; pressure; prevent; social; social factors; social influence; social norm; tobacco products; tobacco regulation; tool; transmission process; years of life lost; young adult

PROJECT 2 Abstract Although the literature on nicotine addiction is extensive, the various mechanisms by which an adolescent is exposed, experiments, and ultimately becomes addicted to a nicotine product, have not been studied in a comprehensive manner. There are studies focusing on the biological effects of nicotine on the brain; the social pressures confronting adolescents; and demographic and environmental factors such as race, gender, social norms, socioeconomic status, and education, among others. However, no study has investigated how the interactions among these factors influence an adolescent to start or quit using nicotine. This project proposes to develop a novel comprehensive agent-based model of nicotine addiction among adolescents and young adults, including the influence of environmental, social, and biological factors on individuals' behaviors towards nicotine products (Aim 1). Use the model to explore potential pathways of nicotine addiction among adolescents and young adults under different nicotine product mix availability, and the short-term consequences of potential regulatory actions over such products, such as reducing nicotine in combustible tobacco products to non-addictive levels but allowing higher levels of nicotine in non-combustible nicotine delivery products (Aim 2). Project the likely long-term consequences of nicotine addiction among adolescents and young adults, including tobacco-use-attributed premature deaths and life-years-lost, and long-term nicotine dependence (Aim 3). This project will focus on Addiction, Behavior, Impact Analysis and Health Effects as Scientific Domains (RFA-OD-22-04).

项目2