Modeling the Process of Nicotine Addiction among Youths and Young Adults and Its Potential Future Consequences

项目2摘要 尽管有关尼古丁成瘾的文献很多，但青少年吸烟的各种机制 暴露，实验，并最终对尼古丁产品上瘾，还没有研究过 全面的态度。有关于尼古丁对大脑的生物学影响的研究；社会 青少年面临的压力；以及种族、性别、社会等人口和环境因素 规范、社会经济地位和教育等。然而，还没有一项研究调查过 这些因素之间的相互作用会影响青少年开始或停止使用尼古丁。这个项目提出了 建立一种新的青少年尼古丁成瘾综合药剂模型 成人，包括环境、社会和生物因素对个人行为的影响 尼古丁产品(目标1)。使用该模型来探索尼古丁成瘾的潜在途径 青少年和青壮年在不同尼古丁产品组合下的可用性，以及短期内 对这类产品可能采取的监管行动的后果，例如减少可燃物品中的尼古丁 烟草产品达到不会上瘾的水平，但允许不可燃烧尼古丁中的尼古丁含量更高 交付产品(目标2)。预测青少年尼古丁成瘾可能产生的长期后果 年轻人，包括吸烟导致的过早死亡和寿命损失，以及长期尼古丁 依赖(目标3)。该项目将关注成瘾、行为、影响分析和对健康的影响，如 科学领域(RFA-OD-22-04)。

PROJECT 2 Abstract Although the literature on nicotine addiction is extensive, the various mechanisms by which an adolescent is exposed, experiments, and ultimately becomes addicted to a nicotine product, have not been studied in a comprehensive manner. There are studies focusing on the biological effects of nicotine on the brain; the social pressures confronting adolescents; and demographic and environmental factors such as race, gender, social norms, socioeconomic status, and education, among others. However, no study has investigated how the interactions among these factors influence an adolescent to start or quit using nicotine. This project proposes to develop a novel comprehensive agent-based model of nicotine addiction among adolescents and young adults, including the influence of environmental, social, and biological factors on individuals' behaviors towards nicotine products (Aim 1). Use the model to explore potential pathways of nicotine addiction among adolescents and young adults under different nicotine product mix availability, and the short-term consequences of potential regulatory actions over such products, such as reducing nicotine in combustible tobacco products to non-addictive levels but allowing higher levels of nicotine in non-combustible nicotine delivery products (Aim 2). Project the likely long-term consequences of nicotine addiction among adolescents and young adults, including tobacco-use-attributed premature deaths and life-years-lost, and long-term nicotine dependence (Aim 3). This project will focus on Addiction, Behavior, Impact Analysis and Health Effects as Scientific Domains (RFA-OD-22-04).