Activation and inhibition of the Plasminogen/Plasmin system

纤溶酶原/纤溶酶系统的激活和抑制

• 批准号: nhmrc : GNT1127593
• 负责人: Dr Ruby Law
• 金额: $ 80.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-inhibition-plasminogenplasmin/1347633
• 关键词: Activation; inhibition; Plasminogen; Plasmin; system

Plasmin is crucial enzyme present in blood plasma that functions in clot dissolution, inflammation, tissue remodeling, and wound healing. We aim to study how this enzyme system is controlled, by studying its interaction with receptors, co-factors and inhibitors. The information we gain will help drive the development of new generation therapeutics for the fine control of plasmin function in clotting disease, bleeding and inflammation.

纤溶酶是存在于血浆中的关键酶，其在凝块溶解、炎症、组织重塑和伤口愈合中起作用。我们的目标是研究这种酶系统是如何控制的，通过研究它与受体，辅因子和抑制剂的相互作用。我们获得的信息将有助于推动新一代治疗药物的开发，以精细控制凝血疾病，出血和炎症中的纤溶酶功能。