Bio-Layer Interferometry (BLI) Octet R8

生物层干涉测量 (BLI) 八位字节 R8

• 批准号: 10632961
• 负责人: Maryam Raeeszadeh Sarmazdeh
• 金额: $ 31.28万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10632961
• 关键词: Address; Award; Biosensing Techniques; Centers of Research Excellence; DNA-Protein Interaction; Development; Diagnosis; Engineering; Funding; Institution; Interferometry; Medicine; Neurosciences; Nevada; Proteins; Request for Proposals; Research Personnel; Science; Therapeutic; Time; United States National Institutes of Health; college; drug discovery; high throughput screening; imaging facilities; instrument; interdisciplinary collaboration; molecular imaging; nanoparticle; small molecule

Project Summary/Abstract This proposal requests funding for an Octet R8 to support NIH Institutional Development Award (IDeA) centers in the state of Nevada and NIH-funded researchers. A significant portion of the instrument time would be to address the needs of NIH-funded investigators across the campus via interdisciplinary collaborations and support between colleges of engineering, science, and medicine. The Octet R8 will also provide support for the Nevada INBRE, Integrative Neuroscience Center of Biomedical Research Excellence (COBRE) and the Cellular, Molecular Imaging Center funded by NIH. The Octet R8 will allow researchers to perform new types of biosensing, drug discovery, and diagnosis including protein-protein, protein-small molecule, protein nanoparticles, and protein-DNA interaction studies in real-time and high-throughput screening of potential therapeutics, and sensitive biomolecular sensing application.

项目总结/摘要 该提案要求为Octet R8提供资金，以支持NIH机构发展奖 （IDEA）中心在内华达州和NIH资助的研究人员。的很大一部分 仪器时间将是为了满足整个校园NIH资助的研究人员的需求 通过跨学科的合作和支持之间的工程学院，科学， 药Octet R8还将为内华达州的INBRE、Integrative 卓越生物医学研究神经科学中心（COBRE）和细胞、分子 由NIH资助的成像中心。Octet R8将使研究人员能够执行新类型的 生物传感，药物发现和诊断，包括蛋白质-蛋白质，蛋白质-小分子， 蛋白质纳米颗粒和蛋白质-DNA相互作用的实时和高通量研究 潜在治疗剂的筛选和灵敏的生物分子传感应用。