Automated Digital Imaging for Cervical Cancer Screening

用于宫颈癌筛查的自动数字成像

• 批准号: 10634569
• 负责人: Louise Kuhn
• 金额: $ 51.65万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-06 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634569
• 关键词: Acceleration; Acetic Acids; Address; Algorithms; Automobile Driving; Biological Assay; Biopsy; Cellular Phone; Cervical; Cervical Cancer Screening; Cervical Intraepithelial Neoplasia; Cervix Uteri; Characteristics; Classification; Clinical; Collaborations; Colposcopes; Colposcopy; Cytology; DNA; Data; Development; Diagnosis; Effectiveness; FDA approved; General Population; Generations; Goals; HIV; Health Services; High Prevalence; Histologic; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Image; Imaging technology; Incidence; India; Infrastructure; Investigation; Lesion; Licensing; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Marketing; Methods; Modeling; Morbidity - disease rate; Output; Performance; Predictive Value; Prevalence; Price; Primary Prevention; Procedures; Provider; Qualifying; Recommendation; Reporting; Resources; Risk; Safety; Secondary Prevention; Services; South Africa; South African; Specificity; Testing; Time; Triage; Universities; Visit; Visual; Woman; Women' s Group; Work; World Health Organization; antiretroviral therapy; automated visual evaluation; clinical research site; cloud based; cost; cost effective; cost effectiveness; digital; digital imaging; effectiveness study; high risk population; histological specimens; implementation evaluation; improved; low and middle-income countries; machine learning algorithm; mortality; new technology; point of care; programs; randomized, clinical trials; recruit; screening; screening program; screening services; success

Project Abstract/Summary: Cervical cancer screening programs remain essential to reduce cervical cancer in women despite the availability of human papilloma virus (HPV) vaccines. Screening is important for all women but is particularly important for women living with HIV given the high prevalence of HPV in this group and risks associated with progression notwithstanding antiretroviral therapy. Here we propose to investigate the clinical utility of a new method of automated digital imaging of the cervix on the MobileODT platform as a screen-and-treat approach. We build on a long-term collaboration between the University of Cape Town and Columbia University investigating how to strengthen cervical cancer screening and treatment in South Africa. Currently, screen-and-treat programs utilizing HPV DNA testing are recommended by the World Health Organization. We have demonstrated the safety, efficacy and cost-effectiveness of this approach for the South African setting with its high HIV prevalence in women. In this setting, we are currently completing an NCI- supported study demonstrating the feasibility and outstanding performance of an HPV DNA assay that can be used at the point-of-care for a single-visit, screen-and-treat program. Here we propose to extend this work to investigate in Specific Aim 1: the performance characteristics of automated digital imaging as a standalone, primary screening test to replace HPV DNA testing for use in the single-visit, screen-and-treat approach; Specific Aim 2: the performance characteristics of automated digital imaging as a triage test for women who test HPV DNA positive in the screen- and-treat approach; and Specific Aim 3: facility-level operational challenges and facilitators to integrating this new imaging technology into single-visit screen-and-treat programs. We propose to undertake the studies to address these aims among women living with and without HIV at clinical sites in Cape Town, South Africa. Our overall goal is to strengthen cervical cancer screening approaches to reduce cost and improve the effectiveness of screening.

抽象/项目简介:

项目成果

Assessment of the implementation context in preparation for a clinical study of machine-learning algorithms to automate the classification of digital cervical images for cervical cancer screening in resource-constrained settings.

• DOI: 10.3389/frhs.2022.1000150
• 发表时间: 2022
• 期刊: FRONTIERS IN HEALTH SERVICES
• 作者: Castor, Delivette;Saidu, Rakiya;Boa, Rosalind;Mbatani, Nomonde;Mutsvangwa, Tinashe E M;Moodley, Jennifer;Denny, Lynette;Kuhn, Louise
• 通讯作者: Kuhn, Louise

Clinical Utility of Reflex Testing with Cancer Biomarkers to Improve Diagnostic Accuracy of Primary Human Papillomavirus Screening.

用癌症生物标志物进行反射测试的临床实用性，以提高原发性人乳头瘤病毒筛查的诊断准确性。

• DOI: 10.1158/1055-9965.epi-21-0972
• 发表时间: 2022-03-01
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Johnson LG;Saidu R;Svanholm-Barrie C;Boa R;Moodley J;Tergas A;Persing D;Campbell SA;Tsai WY;Wright TC;Denny L;Kuhn L
• 通讯作者: Kuhn L