Sexual Development of Cryptosporidium
隐孢子虫的性发育
基本信息
- 批准号:10633278
- 负责人:
- 金额:$ 44.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-11-07 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAcquired Immunodeficiency SyndromeApicalAtlasesBiological AssayCell Cycle RegulationCellsCessation of lifeChildChild HealthChildhoodChromosome MappingCryo-electron tomographyCryptosporidiosisCryptosporidiumCytoskeletonDedicationsDevelopmentDiarrheaDiseaseDisease OutbreaksDockingElementsEpigenetic ProcessEventFemaleFertilizationFlagellaFutureGametogenesisGene ExpressionGenesGeneticGenetic TranscriptionGenetic studyGenomeGerm CellsHIV/AIDSImmunocompetentImmunosuppressionIndividualInfantInfectionIntestinesLife Cycle StagesLinkMalignant NeoplasmsMalnutritionMapsMeasuresMethodsModelingMolecularNutritional statusOpportunistic InfectionsOrgan TransplantationParasitesPatientsPharmaceutical PreparationsPhasePredispositionPreventionProcessProgram DevelopmentProphylactic treatmentProteinsPublic HealthReproduction sporesResistanceResolutionRisk FactorsRoleRotavirusSexual DevelopmentSpecificitySporozoitesStructureSubcellular structureSystemTechnologyTestingVaccinesWaterasexualchlorinationdiarrheal diseaseeffective therapyelectron tomographygain of functionhistone modificationimprintinsightinterestintestinal epitheliumlive cell imagingloss of functionmalemortalitymutantnext generationoverexpressionpathogenprogramssexsingle cell sequencingtranscription factortransmission processwaterborne illness
项目摘要
Project Abstract
The protozoan parasite Cryptosporidium is one of the most important causes of severe diarrheal
disease. In the U.S. this parasite is responsible for half of all waterborne disease outbreaks, some
of which have occurred at massive scale. Patients suffering from immunosuppression due to
HIV/AIDS, organ transplantation, or cancer are in gravest danger. The global public health
impact is even larger: after Rotavirus, Cryptosporidium is the most important diarrheal pathogen
in small children. In particular in the context of malnutrition, cryptosporidiosis has a highly
significant imprint on childhood mortality. Cryptosporidiosis is also linked to stunting, thus
leaving a lasting shadow on the future of children. This parasite has a single host life cycle,
asexual and sexual processes occur sequentially in the intestinal epithelium of the same host.
Completion of this developmental program is required for continued infection, severe disease,
and transmission. We have built robust experimental systems to observe and manipulate the
sexual development of Cryptosporidium and we unraveled key elements of the mechanisms that
control the underlying gene expression systems. In this application we will define the epigenetic
mechanisms that govern transition from asexual to sexual replication, we will unravel how the
parasites choses between a male or female fate, and we will use emerging cyro-electron
tomography and parasite genetics to understand how the unique ultrastructure of male gametes
enables fertilization. The resulting findings will impact on our fundamental understanding of
parasite development and on translational efforts to develop drugs and vaccines.
项目摘要
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Live imaging of the Cryptosporidium parvum life cycle reveals direct development of male and female gametes from type I meronts.
- DOI:10.1371/journal.pbio.3001604
- 发表时间:2022-04
- 期刊:
- 影响因子:9.8
- 作者:
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BORIS STRIEPEN其他文献
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