Mentoring patient-oriented research to improve cardiovascular health among people with HIV in sub-Saharan Africa

项目总结 概述。这个K24职业生涯中期研究员奖将支持Mark Siedner博士领导一个指导计划 在以患者为中心的艾滋病毒感染者心血管疾病检测和预防研究中 撒哈拉以南非洲。 候选人。西德纳博士是一名内科科学家，是四家NIH的首席研究员(PI)或联合PI R01资助的撒哈拉以南地区艾滋病毒和/或心血管疾病患者导向研究(POR)项目 非洲，产生了220多份同行评议的出版物。他也证明了自己是一个非常成功的 导师，与二十多名过去和现在的实习生一起，接受哈佛医学院青年导师 获奖，他在MGH(T32)担任NIH T32项目艾滋病毒临床研究的联合主任就是明证 AI007433)，乌干达多发病全球D43临床研究培训计划的现场PI(D43 TW011632)，以及Fogarty临床研究奖学金项目导师(D43 T010543)。 指导计划。这一K24奖项将使西德纳博士能够保护他25%的时间用于培训 美国和撒哈拉以南非洲POR与心血管疾病预防相关的初级调查人员 在艾滋病毒携带者中。他将利用已建立的临床研究实习生渠道，通过 他在培训拨款和正式制定全球心血管疾病研究培训计划方面的领导作用 它关注职业发展，并将美国和非洲的科学家与合作项目配对。 研究计划。西德纳博士将利用这一奖项提供的支持，在职业生涯中期进行 机器学习和临床风险预测。他将利用机器学习培训和合作伙伴关系 与数据科学专家一起全面评估和验证诊断的单个和组合 撒哈拉以南非洲艾滋病毒感染者的心血管疾病筛查方式(目标1和2)。 这将通过来自NHLBI资助的R01的数据来实现，其中包括CT血管成像和广泛的 乌干达600人的风险因素数据。在第二个项目中，他将使用风险预测技术来 推导和验证南非艾滋病毒携带者的心血管疾病风险预测得分(目标 3)。这将通过惠康信托资助的、基于人口的纵向队列研究来实现。 南非18,000名完成心血管疾病筛查并接受跟踪调查的人 住院和死亡。拟议的工作直接与NIH概述的研究优先事项一致，而不是- 020-013包括预防艾滋病毒终生合并症和研究培训 多学科的员工队伍。此外，西德纳博士长期致力于培训初级科学家 Por，特别是他对妇女和个人事业发展的奉献-- 在科学界具有代表性，使他成为这一奖项的优秀候选人。

PROJECT SUMMARY Overview. This K24 mid-career investigator award will support Dr. Mark Siedner to lead a mentoring program in patient-oriented research on detection and prevention of cardiovascular disease among people with HIV in sub-Saharan Africa. Candidate. Dr. Siedner is a physician scientist who serves as principal investigator (PI) or co-PI of four NIH R01-funded patient-oriented research (POR) projects on HIV and/or cardiovascular disease in sub-Saharan Africa, leading to over 220 peer-reviewed publications. He has also proven himself to be a highly successful mentor, with over two dozen past and current trainees, receipt of the Harvard Medical School Young Mentor Award, and evidenced by his role as co-director of an NIH T32 program in HIV clinical research at MGH (T32 AI007433), site PI of a global D43 clinical research training program on multimorbidity in Uganda (D43 TW011632), and program mentor in the Fogarty Clinical Research Fellowship (D43 T010543). Mentoring plan. This K24 award will allow Dr. Siedner to protect 25% of his time to be dedicated for training junior investigators in the US and sub-Saharan Africa in POR related to cardiovascular disease prevention among people with HIV. He will leverage an established pipeline of clinical research trainees identified through his leadership role on training grants and formalize a global cardiovascular disease research training program that focuses on career advancement and pairs US and African scientists with collaborative projects. Research Plan. Dr. Siedner will use the support provided by this award to pursue mid-career training in machine learning and clinical risk prediction. He will leverage the machine learning training and partnerships with experts in data science to comprehensively assess and validate individual and combinations of diagnostic screening modalities for cardiovascular disease among people with HIV in sub-Saharan Africa (Aims 1 and 2). This will be made possible with data from an NHLBI-funded R01 that includes CT angiography and extensive risk factor data in 600 individuals in Uganda. In a second project, he will use risk prediction techniques to derive and validate cardiovascular disease risk prediction scores among people with HIV in South Africa (Aim 3). This will be made possible by a Wellcome Trust-funded, population-based, longitudinal cohort study of over 18,000 people in South Africa who completed cardiovascular disease screening and are followed until hospitalization and death. The proposed work is directly in line with research priorities outlined in NIH NOT- 020-013 including prevention of HIV co-morbid conditions across the lifespan and research training of a multidisciplinary workforce. Moreover, Dr. Siedner’s longstanding commitment to training junior scientists in POR, and particularly his dedication to the advancement of careers of women and individuals under- represented in science, make him an excellent candidate for this award.