Women, Intersectionality, Substance Use and HIV ( WISH)

妇女、交叉性、药物滥用和艾滋病毒 (WISH)

• 批准号: 10667625
• 负责人: Jennifer Payaal Jain
• 金额: $ 18.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667625
• 关键词: Acceleration; Address; Adherence; Anti-Retroviral Agents; Applied Research; Award; Black race; Caring; Cohort Studies; Data; Development Plans; Discrimination; Drug usage; Epidemic; Epidemiologic Methods; Equity; Evidence based intervention; Failure; Feedback; Focus Groups; Goals; HIV; HIV/AIDS; Health; Health Personnel; Health Status; High Prevalence; Inequality; Intervention; Interview; Lead; Learning; Link; Manuscripts; Mediator; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Modeling; Monitor; Outcome; Persons; Pilot Projects; Population; Process; Protocols documentation; Race; Reporting; Research; Research Support; Resources; San Francisco; Science; Scientific Advances and Accomplishments; Stigmatization; Structure; Surveys; System; Techniques; Testing; Training; Training Activity; Treatment outcome; United States; United States National Institutes of Health; Viral; Woman; Work; Writing; acceptability and feasibility; antiretroviral therapy; arm; career; career development; ethnoracial; experience; improved; intersectionality; knowledge base; mortality; post intervention; promote resilience; prospective; racial diversity; recruit; resilience; response; satisfaction; skills; social stigma; substance use; success; theories; therapy adherence; therapy design; treatment as prevention; treatment optimization

PROJECT SUMMARY/ABSTRACT The purpose of this Mentored Research Scientist Development Award (K01) is to provide the candidate with the training and expertise needed to transition into an independent research career focused on intersectional approaches to optimize HIV treatment and intervention. This K01 features a robust career development plan and carefully linked research strategy. The overall objective of the research component of this K01 is to examine how intersectional stigma and discrimination lead to inequalities in HIV treatment outcomes and explore how resilience promotes engagement in HIV care among racially diverse women living with HIV who use drugs (WLHIV-WUD) in the United States (US). This information will inform the selection and systematic adaptation of an HIV-related evidence-based intervention (EBI) to facilitate engagement in care among WLHIV-WUD. This will be achieved through the following three specific aims: 1) to assess the impact of stigma and discrimination on inequalities in HIV treatment outcomes across intersections of drug use and race among racially diverse WLHIV in the US; 2) to systematically adapt an HIV-related EBI to mitigate the impact of intersectional stigma and discrimination and cultivate resilience to facilitate HIV care engagement among racially diverse WLHIV-WUD in San Francisco, CA; and 3) to evaluate the acceptability and feasibility of the adapted intersectionality-informed HIV care engagement intervention among racially diverse WLHIV-WUD in San Francisco, CA. Dr. Jennifer Jain is the perfect candidate to conduct this research because of her strong knowledge base in epidemiological methods and HIV and substance use research. During the 5-year award period, Dr. Jain will achieve the following career development objectives: 1) gain content expertise in intersectionality theory and research with an emphasis on HIV care engagement among WLHIV-WUD in the US; 2) develop methodological expertise in advanced statistical techniques for quantitative intersectionality and mixed methods; 3) acquire training in intervention science, including the adaptation and testing of evidence- based interventions focused on HIV care engagement among WLHIV-WUD in the US; 4) build skills for a successful independent research career, including grantsmanship, scientific manuscript writing and collaborative cross-disciplinary research. This will be attained through the completion of a diverse set of training activities including mentor-directed learning, formal course work, seminars, and real-world research experience. The proposed research is highly consistent with current NIH priorities to: 1) conduct HIV-related intersectional stigma research; 2) improve health outcomes among people living with HIV who use drugs; and 3) accelerate scientific discoveries in HIV/AIDS and substance use research. Moreover, this research supports Dr. Jain’s pursuit of an independent career in research focused on intersectional approaches to enhance HIV treatment and intervention among racially diverse WLHIV-WUD in the US.

项目摘要/摘要 该指导研究科学家发展奖(K01)的目的是为候选人提供 过渡到专注于跨部门研究的独立研究职业所需的培训和专业知识 优化艾滋病毒治疗和干预的方法。这款K01具有强大的职业发展计划 和仔细联系的研究策略。本K01研究部分的总体目标是 审查跨部门的耻辱和歧视如何导致艾滋病毒治疗结果的不平等以及 探索复原力如何促进不同种族的艾滋病毒携带者妇女参与艾滋病毒护理 在美国使用药物(WLHIV-WUD)。这些信息将通知选拔和系统化 调整艾滋病毒相关循证干预措施(EBI)，以促进 哇哇哇。这将通过以下三个具体目标来实现：1)评估污名的影响 以及关于艾滋病毒治疗结果在药物使用和种族之间的不平等的歧视 美国种族多元化的WLHIV；2)系统地调整与艾滋病毒相关的EBI，以减轻 跨部门的耻辱和歧视，并培养复原力，以促进 种族多元化的WLHIV-WUD在加州旧金山；和3)评估可接受性和可行性 在不同种族的WLHIV-WUD中进行适应的交叉性知情艾滋病毒护理参与干预 加利福尼亚州旧金山Jennifer Jain博士是进行这项研究的完美人选，因为她的力量 流行病学方法和艾滋病毒及药物使用研究方面的知识库。在为期5年的奖项期间 在此期间，Jain博士将实现以下职业发展目标：1)获得内容方面的专业知识 交叉性理论和研究，重点是WLHIV-WUD中艾滋病毒关怀的参与度 美国；2)发展先进统计技术方面的方法学专门知识，以促进量化交叉和 混合方法；3)获得干预科学方面的培训，包括调整和检验证据-- 以干预措施为基础，重点关注美国WLHIV-WUD中的艾滋病毒护理参与；4)为 成功的独立研究生涯，包括格兰特精神、科学手稿写作和 协作性跨学科研究。这将通过完成一套不同的 培训活动包括导师指导的学习、正式的课程工作、研讨会和现实世界的研究 经验。这项拟议的研究与NIH目前的优先事项高度一致：1)进行与艾滋病毒有关的 跨部门污名研究；2)改善艾滋病毒携带者使用药物的健康结果；以及 3)加快艾滋病毒/艾滋病和药物使用研究的科学发现。此外，这项研究还支持 Jain博士追求独立的研究生涯，专注于跨部门方法来增强艾滋病毒 美国不同种族的WLHIV-WUD的治疗和干预。