Subicular Contributions to Memory-Guided Decision Making

对记忆引导决策的潜意识贡献

• 批准号: 10670412
• 负责人: Jacob Michael Olson
• 金额: $ 12.15万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10670412
• 关键词: Address; Alzheimer' s Disease; Anatomy; Anxiety; Anxiety Disorders; Award; Behavior; Behavioral; Behavioral Paradigm; Brain region; Categories; Characteristics; Code; Cognitive; Collaborations; Complement; Complex; Data; Decision Making; Development; Development Plans; Disease; Disparate; Dorsal; Educational process of instructing; Electrophysiology (science); Emotional; Epilepsy; Etiology; Event; Exhibits; Functional disorder; Future; Hippocampus; Individual; Insula of Reil; Interruption; Lead; Learning; Link; Location; Medial; Memory; Mental Depression; Mental disorders; Mentors; Modeling; Nature; Neurons; Neurophysiology - biologic function; Neurosciences; Output; Pathologic; Pathway interactions; Pattern; Performance; Periodicity; Phase; Physiological; Physiology; Play; Population; Post-Traumatic Stress Disorders; Process; Property; Psychology; Pyramidal Cells; Rattus; Reader; Research; Research Personnel; Rewards; Role; Scheme; Schizophrenia; Shapes; Short-Term Memory; Signal Transduction; Techniques; Temporal Lobe; Testing; Theoretical model; Time; Training; Universities; awake; biophysical model; cognitive ability; cognitive function; cognitive process; cognitive task; density; effective intervention; effective therapy; entorhinal cortex; experience; experimental study; hedonic; hippocampal subregions; in vivo; innovation; memory encoding; memory retrieval; neural; neural circuit; neuromechanism; neurophysiology; novel; optogenetics; predictive modeling; programs; theories; virtual; way finding

PROJECT SUMMARY The ability to form and store memories from experience to shape future behavior is a remarkable and foundational cognitive capability. While many brain regions interact to enable cognitive processes of learning and decision making, the subiculum and hippocampus of the medial temporal lobe are central nodes in the underlying neural circuit. Accordingly, medial temporal lobe dysfunction is a hallmark of psychiatric disorders such as depression, PTSD and other anxiety disorders, epilepsy, and Alzheimer’s disease. Understanding basic neural function and coordination processes in the subiculum and hippocampus during memory and decision making will therefore be crucial in the progress towards effective interventions for these disorders; however, subiculum function and its coordination with hippocampus during these cognitive tasks is almost completely unknown. The central hypothesis of this proposal is that subiculum links individual memories formed by the hippocampus and thereby enables cognitive capabilities such as abstraction, categorization, and deliberation during decision making. During the mentored phase (K99), high-density in vivo electrophysiology will be used in rats to observe subiculum and hippocampal subregion CA1 activity during a navigational memory-guided decision making task. Optogenetic interruption of the proposed coordination mechanism between subiculum and CA1 during behavior will then provide evidence to its necessity for memory-guided decision making. Theoretical models will assess plausible mechanisms underlying the formation of subiculum activity patterns. Experiments during the independent (R00) phase will extend this approach through the dorsal-ventral extent of CA1 and subiculum and to emotional aspects of memory such as hedonic value. Successful completion of this proposal has the potential to result in two significant conceptual breakthroughs: 1) subiculum is a major and critical component of hippocampal output with specific and distinct functions during memory-guided decision making, 2) subiculum and CA1 function and encoding properties are consistent throughout their dorsal-ventral extents and are best understood under a single conceptual framework. This research plan will be executed by Dr. Jacob Olson under the guidance of Dr. Shantanu Jadhav and Dr. Donald Katz, facilitated by the collaborative, innovative, and rigorous nature of the Neuroscience Program and Department of Psychology at Brandeis University. This proposal also contains a comprehensive training and development plan with emphases on cutting-edge recoding and manipulation techniques, theoretical modeling, and scholarly development to fully prepare Dr. Olson to lead an innovative and impactful research program studying the mechanisms of neural coordination underlying memory-guided decision making as an independent investigator.

项目摘要 从经验中形成和储存记忆以塑造未来行为的能力是一种非凡的， 基础认知能力。虽然许多大脑区域相互作用，使认知过程的学习 和决策，内侧颞叶的下托和海马是中央节点， 潜在的神经回路因此，内侧颞叶功能障碍是精神障碍的标志 如抑郁症、创伤后应激障碍和其他焦虑症、癫痫和阿尔茨海默病。了解基本 海马下托和海马在记忆和决策过程中的神经功能和协调过程 因此，在对这些疾病进行有效干预方面取得进展至关重要;然而， 在这些认知任务中，下托功能及其与海马的协调几乎完全 未知这一提议的中心假设是，下托连接着由下托形成的个体记忆。 海马体，从而使认知能力，如抽象，分类和审议 在决策过程中。在指导阶段（K99），高密度体内电生理学将用于 观察大鼠海马下托和海马CA 1区在导航记忆过程中的活动 决策任务。下托和下托之间协调机制的光遗传中断 然后，行为过程中的CA 1将提供证据，证明它对记忆引导的决策的必要性。理论 模型将评估下托活动模式形成的可能机制。实验 在独立（R 00）阶段，将通过CA 1的背腹侧范围扩展该入路， 下托和记忆的情感方面，如享乐价值。成功完成本提案 有可能导致两个重大的概念突破：1）下托是一个主要的和关键的 海马输出的组成部分，在记忆引导的决策过程中具有特定和独特的功能， 2)下托和CA 1的功能和编码特性在它们的背腹侧范围内是一致的 在一个单一的概念框架下最好理解。这项研究计划将由雅各布博士执行 奥尔森在Shantanu Jadhav博士和Donald Katz博士的指导下， 创新，神经科学计划和布兰代斯心理学系的严谨性质 大学该建议还包括一个全面的培训和发展计划，重点是 尖端的重新编码和操作技术，理论建模和学术发展，以充分 准备奥尔森博士领导一个创新的和有影响力的研究计划，研究神经的机制， 作为一个独立的调查者，协调记忆引导的决策。