Acute severe ulcerative colitis - clinical and translational studies

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Ulcerative colitis is a disease that causes damage to the lining of the bowel wall. Twenty percent of patients have a severe form of the condition. A third of patients do not get better with steroids and need infliximab, a stronger medication to help avoid emergency surgery to remove the large bowel. Our study aims to assess whether giving larger or more frequent doses of infliximab improves the chances of patients getting better and avoiding the need for surgery.