Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women
预防先兆子痫非裔美国女性产后心功能不全的指南指导管理和治疗 (GDMT)
基本信息
- 批准号:10675331
- 负责人:
- 金额:$ 34.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAfrican AmericanAspirinBlood PressureCardiac developmentCardiovascular DiseasesCardiovascular Pregnancy ComplicationsCessation of lifeClinicalClinical TrialsDataDeteriorationDevelopmentEFRACEarly DiagnosisEvaluationFunctional disorderGoalsGuidelinesHeartHeart RateHeart failureHypertensionIncidenceInterdisciplinary StudyInterventionKnowledgeLeadLearningLeftLifeMeasuresMediationMedicalMethodologyMonitorMorbidity - disease rateMothersMyocardial dysfunctionOrganParentsPatientsPostpartum HypertensionPostpartum PeriodPre-EclampsiaPregnancyPregnant WomenPrevention therapyPulmonary EdemaRaceRandomizedRandomized Controlled TrialsRecording of previous eventsStrokeTestingTimeVentricular FunctionVisitWomanactivin Aantenatalblood pressure controlblood pressure elevationblood pressure reductioncardiogenesisclinically relevantcohortcompare effectivenessepidemiology studyheart functionhypertensivehypertensive heart diseaseimprovedinnovationmortalitypregnantpreventracial and ethnicrandomized trial
项目摘要
Project Summary/Abstract
African American women are 60% more likely to have postpartum hypertension and are nearly three times
more likely to die from preeclampsia than white women. Both during pregnancy and overall, hypertension in
African American women is more severe and presents earlier in life. In addition, compared to other ethnic-
racial groups, African American women have higher mortality rates from hypertension-related end-organ
damage like heart failure and stroke. Currently, however, no proven interventions exist to prevent or mitigate
the development of hypertensive heart disease during the postpartum period.
Using a randomized mechanistic clinical trial of guideline-directed medical therapy for postpartum African
American women with preeclampsia, we will advance knowledge of cardiac dysfunction in preeclampsia and its
possible treatments. We pursue a specific aim to answer these questions. AIM 1 is a randomized trial to test
whether guideline-directed medical therapy improves cardiac function and decreases blood pressure in
postpartum African American women with preeclampsia. This project innovates methodologically to
dramatically advance our understanding of a significant cause of morbidity and mortality in African American
women.
项目总结/文摘
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Sajid Shahul其他文献
Sajid Shahul的其他文献
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{{ truncateString('Sajid Shahul', 18)}}的其他基金
Aspirin to prevent cardiac dysfunction in preeclampsia
阿司匹林预防子痫前期心功能障碍
- 批准号:
10321956 - 财政年份:2021
- 资助金额:
$ 34.36万 - 项目类别:
Aspirin to prevent cardiac dysfunction in preeclampsia
阿司匹林预防子痫前期心功能障碍
- 批准号:
10541134 - 财政年份:2021
- 资助金额:
$ 34.36万 - 项目类别:
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