Hormone receptor associated epigenetic reprogramming as a mediator of environmental exposure in women's health

激素受体相关的表观遗传重编程作为女性健康环境暴露的中介

• 批准号: 10699690
• 负责人: Elizabeth Martin
• 金额: $ 64.51万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699690
• 关键词: Breast Cancer Risk Factor; Cell Proliferation; Cells; Disease; Endocrine Disruptors; Endocrine disruption; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Exposure to; Goals; Hormonal Change; Hormone Receptor; Lead; Ligands; Mediator of activation protein; Phenotype; Predisposition; Pregnancy; Progesterone; Progesterone Receptors; Research; T47D; Women' s Health; activating transcription factor; maternal risk; phthalates; programs; receptor

In this past year we have demonstrated that phthalates can impact the phenotype, specifically cell proliferation, of T47D cells in culture. Further, this phenotype is altered in the presence of endogenous progesterone suggesting endocrine disruption via progesterone receptor as a potential mechanism by which phthalate exposure may later breast cancer risk. These findings also suggest that exposure to endocrine disrupting compounds such as phthalates maybe more important during key windows of susceptibility, such as pregnancy.

在过去的一年里，我们已经证明邻苯二甲酸盐可以影响培养的T47D细胞的表型，特别是细胞增殖。此外，这种表型在内源性黄体酮存在下发生改变，表明通过黄体酮受体的内分泌干扰是邻苯二甲酸盐暴露可能会增加乳腺癌风险的潜在机制。这些发现还表明，在关键的易感期（如怀孕期），接触邻苯二甲酸盐等内分泌干扰化合物可能更为重要。