Hormone receptor associated epigenetic reprogramming as a mediator of environmental exposure in women's health

在过去的一年里，我们已经证明邻苯二甲酸盐可以影响培养的T47D细胞的表型，特别是细胞增殖。此外，这种表型在内源性黄体酮存在下发生改变，表明通过黄体酮受体的内分泌干扰是邻苯二甲酸盐暴露可能会增加乳腺癌风险的潜在机制。这些发现还表明，在关键的易感期（如怀孕期），接触邻苯二甲酸盐等内分泌干扰化合物可能更为重要。

In this past year we have demonstrated that phthalates can impact the phenotype, specifically cell proliferation, of T47D cells in culture. Further, this phenotype is altered in the presence of endogenous progesterone suggesting endocrine disruption via progesterone receptor as a potential mechanism by which phthalate exposure may later breast cancer risk. These findings also suggest that exposure to endocrine disrupting compounds such as phthalates maybe more important during key windows of susceptibility, such as pregnancy.