Hormone receptor associated epigenetic reprogramming as a mediator of environmental exposure in women's health

在过去的一年里，我们证明了邻苯二甲酸盐可以影响培养中的T47D细胞的表型，特别是细胞增殖。此外，在内源性孕酮存在的情况下，这种表型会发生改变，这表明通过孕激素受体的内分泌干扰是邻苯二甲酸盐暴露可能导致乳腺癌风险的潜在机制。这些发现还表明，在关键的易感窗口，如怀孕期间，接触邻苯二甲酸盐等内分泌干扰物可能更重要。

In this past year we have demonstrated that phthalates can impact the phenotype, specifically cell proliferation, of T47D cells in culture. Further, this phenotype is altered in the presence of endogenous progesterone suggesting endocrine disruption via progesterone receptor as a potential mechanism by which phthalate exposure may later breast cancer risk. These findings also suggest that exposure to endocrine disrupting compounds such as phthalates maybe more important during key windows of susceptibility, such as pregnancy.