Drive to Zero: Developing a digital cohort to understand the drivers of non-sustained viral suppression in the Deep South
驱向零:开发数字队列以了解南方腹地非持续病毒抑制的驱动因素
基本信息
- 批准号:10675270
- 负责人:
- 金额:$ 127.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:18 year oldAddressAdherenceAgeAlabamaAreaAutomobile DrivingCaringCase StudyCensusesCenters for Disease Control and Prevention (U.S.)CharacteristicsCollaborationsCommunitiesContinuity of Patient CareCountryDataData CollectionData ReportingDatabasesDeep SouthDependenceDiagnosisElementsEligibility DeterminationEnrollmentEpidemicEpidemiologyExclusionFeedbackFoundationsFundingFutureGeographyGoalsHIVHIV diagnosisHIV/AIDSHealthHealth behaviorHealthcareHeterogeneityIncidenceIndividualInequalityInequityInfectionInformation SystemsInsuranceInterventionInterviewLawsLinkLouisianaLow incomeMeasuresMediatorMethodsMississippiMobile Health ApplicationModelingMorbidity - disease rateNewly DiagnosedOutcomeParticipantPersonsPoliciesPovertyPublic HealthQualitative MethodsRacial SegregationRanaReportingResearchResourcesRoleSamplingSelf ManagementSocial WorkStandardizationSurveysSystemTechnologyTestingTimeU-Series Cooperative AgreementsUnited StatesViralViral Load resultWorkantiretroviral therapycohortcommunity based participatory researchcostdigitalepidemiology studyethnic minority populationevidence baseexperiencefollow-uphealth care availabilityhealth managementimprovedimproved outcomelensmHealthmembermortalitypopulation healthprimary outcomeprospectiveprototypepsychosocialracial minority populationrecruitresidenceresponseservice providerssocialsocial stigmasocial structurestructural determinantssurveillance datasystems researchtherapy adherencetherapy developmenttransmission processtreatment servicestrendusability
项目摘要
PROJECT SUMMARY
A combination of individual-, network-, community-, and structural-level variables impact all steps in the HIV Care
Continuum, particularly in the Deep South states of Alabama (AL), Louisiana (LA), and Mississippi (MS), which
disproportionately bear the nation's HIV burden while simultaneously having the fewest healthcare resources.
While the individual-level correlates of viral suppression (VS) are well-known, few epidemiologic studies,
especially those that are digitally-based, have examined VS from a multilevel lens that accounts for the role of
geographic and community-level characteristics germane to the Deep South, such as aggregate poverty
measures, racial segregation, and healthcare access. Epidemiological studies also typically exclude people with
HIV (PWH) with non-sustained VS (non-VS) or without recent HIV labs, as these are among the hardest to
identify and reach due to their limited healthcare involvement. Our highly experienced study team will address
these research gaps through the proposed UG3-UH3 study, which will use mHealth technology to optimally
recruit, screen, enroll, and retain a prospective digital cohort of 1000 PWH in AL, LA, and MS with non-VS or
who otherwise lack evidence of having been in care for the previous 12 months, leveraging long-standing
relationships with public health departments in each of these three states. We will assemble a community
advisory board (CAB), consisting of PWH, health department partners, and HIV care team members in the three
states and we will use the Information System Research (ISR) Framework to tailor features of an existing
adherence management app for PWH, WiseApp. We will test usability of the Drive to Zero app prototype with
PWH and informaticians. Eligible cohort participants will be PWH ages ≥18 years, living in AL, LA, or MS, living
with HIV for ≥12 months, and entered in the Enhanced HIV/AIDS Reporting System (eHARS), a standardized
document-based surveillance database used by all state health departments to report diagnosis and outcomes,
with a recorded VL≥200 c/mL ≤12 months or have missing HIV lab values during that same period. Participants
will be followed for three years with iterative annual psychosocial quantitative survey assessments conducted
via the Drive to Zero app to assess predictors, mediators, and moderators for non-VS. We will contextualize
quantitative data by using geospatial analysis, linking participant residence addresses at time of enrollment to
Census tract data. Participants of the digital cohort (n=45) will also be eligible to participate in qualitative in-depth
interviews to contextualize quantitative results. The findings from this study will inform efforts to recruit large,
digital cohorts of PWH and will be among the first to demonstrate effective methods of retaining digital cohorts
for HIV as well as other health conditions. Study findings will also help identify multilevel factors that contribute
to non-VS in the Deep South, thereby elucidating future areas for intervention, and will directly lead to a follow-
up R-level application.
项目摘要
个人、网络、社区和结构层面变量的组合影响艾滋病毒护理的所有步骤。
连续体,特别是在南方腹地的亚拉巴马(AL),路易斯安那(LA)和密西西比(MS),
不成比例地承担着国家的艾滋病毒负担,同时拥有最少的医疗资源。
虽然病毒抑制(VS)的个体水平相关性是众所周知的,但很少有流行病学研究,
特别是那些基于数字的,已经从多级透镜中检查了VS,
与南方腹地密切相关的地理和社区层面特征,如总体贫困
措施,种族隔离和医疗保健。流行病学研究通常也排除了患有
HIV(PWH)伴非持续VS(非VS)或近期无HIV实验室,因为这些是最难诊断的
由于他们对医疗保健的参与有限,我们经验丰富的研究团队将解决
通过拟议的UG 3-UH 3研究填补这些研究空白,该研究将使用移动医疗技术,
招募、筛选、入组和保留AL、LA和MS中1000例非VS或
否则他们缺乏过去12个月接受护理的证据,利用长期存在的
与这三个州的公共卫生部门的关系。我们将组建一个社区
顾问委员会(CAB),由威尔斯亲王医院、卫生署合作伙伴和三地的艾滋病护理小组成员组成。
美国,我们将使用信息系统研究(ISR)框架,以调整现有的功能,
PWH、WiseApp的依从性管理应用程序。我们将测试Drive to Zero应用程序原型的可用性,
PWH和信息学家。符合条件的队列受试者将是年龄≥18岁,居住在AL、LA或MS,
感染艾滋病毒≥12个月,并进入增强型艾滋病毒/艾滋病报告系统(eHARS),一个标准化的
所有州卫生部门使用的基于文件的监测数据库,用于报告诊断和结果,
记录的VL≥200 c/mL ≤12个月或在同一时期内HIV实验室值缺失。参与者
将进行为期三年的跟踪调查,并进行反复的年度心理社会定量调查评估
通过Drive to Zero应用程序来评估非VS的预测者,调解者和主持人。我们将
使用地理空间分析,将参与者登记时的居住地址与
人口普查区数据。数字队列的参与者(n=45)也将有资格参加定性深入研究,
访谈,将定量结果置于情境中。这项研究的结果将为招募大型,
并将率先展示保留数码队列的有效方法
艾滋病以及其他健康问题。研究结果还将有助于确定多层次的因素,
到南方腹地的非VS,从而阐明未来的干预领域,并将直接导致以下-
R级应用程序。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David S Batey其他文献
David S Batey的其他文献
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{{ truncateString('David S Batey', 18)}}的其他基金
Promoting Viral Suppression through the CHAMPS+ Intervention in the Deep South
通过 CHAMPS 干预南部腹地促进病毒抑制
- 批准号:
10819823 - 财政年份:2023
- 资助金额:
$ 127.31万 - 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
- 批准号:
10569099 - 财政年份:2021
- 资助金额:
$ 127.31万 - 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
- 批准号:
10161462 - 财政年份:2021
- 资助金额:
$ 127.31万 - 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
- 批准号:
10378666 - 财政年份:2021
- 资助金额:
$ 127.31万 - 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
- 批准号:
10427397 - 财政年份:2020
- 资助金额:
$ 127.31万 - 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
- 批准号:
10632026 - 财政年份:2020
- 资助金额:
$ 127.31万 - 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
- 批准号:
10164175 - 财政年份:2020
- 资助金额:
$ 127.31万 - 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
- 批准号:
10269043 - 财政年份:2020
- 资助金额:
$ 127.31万 - 项目类别:
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
南方腹地从艾滋病毒诊断到病毒抑制的时间地理差异:加速治疗启动的路线图
- 批准号:
10523522 - 财政年份:2018
- 资助金额:
$ 127.31万 - 项目类别:
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
南方腹地从艾滋病毒诊断到病毒抑制的时间地理差异:加速治疗启动的路线图
- 批准号:
10305677 - 财政年份:2018
- 资助金额:
$ 127.31万 - 项目类别:
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