Drive to Zero: Developing a digital cohort to understand the drivers of non-sustained viral suppression in the Deep South

驱向零:开发数字队列以了解南方腹地非持续病毒抑制的驱动因素

基本信息

  • 批准号:
    10675270
  • 负责人:
  • 金额:
    $ 127.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY A combination of individual-, network-, community-, and structural-level variables impact all steps in the HIV Care Continuum, particularly in the Deep South states of Alabama (AL), Louisiana (LA), and Mississippi (MS), which disproportionately bear the nation's HIV burden while simultaneously having the fewest healthcare resources. While the individual-level correlates of viral suppression (VS) are well-known, few epidemiologic studies, especially those that are digitally-based, have examined VS from a multilevel lens that accounts for the role of geographic and community-level characteristics germane to the Deep South, such as aggregate poverty measures, racial segregation, and healthcare access. Epidemiological studies also typically exclude people with HIV (PWH) with non-sustained VS (non-VS) or without recent HIV labs, as these are among the hardest to identify and reach due to their limited healthcare involvement. Our highly experienced study team will address these research gaps through the proposed UG3-UH3 study, which will use mHealth technology to optimally recruit, screen, enroll, and retain a prospective digital cohort of 1000 PWH in AL, LA, and MS with non-VS or who otherwise lack evidence of having been in care for the previous 12 months, leveraging long-standing relationships with public health departments in each of these three states. We will assemble a community advisory board (CAB), consisting of PWH, health department partners, and HIV care team members in the three states and we will use the Information System Research (ISR) Framework to tailor features of an existing adherence management app for PWH, WiseApp. We will test usability of the Drive to Zero app prototype with PWH and informaticians. Eligible cohort participants will be PWH ages ≥18 years, living in AL, LA, or MS, living with HIV for ≥12 months, and entered in the Enhanced HIV/AIDS Reporting System (eHARS), a standardized document-based surveillance database used by all state health departments to report diagnosis and outcomes, with a recorded VL≥200 c/mL ≤12 months or have missing HIV lab values during that same period. Participants will be followed for three years with iterative annual psychosocial quantitative survey assessments conducted via the Drive to Zero app to assess predictors, mediators, and moderators for non-VS. We will contextualize quantitative data by using geospatial analysis, linking participant residence addresses at time of enrollment to Census tract data. Participants of the digital cohort (n=45) will also be eligible to participate in qualitative in-depth interviews to contextualize quantitative results. The findings from this study will inform efforts to recruit large, digital cohorts of PWH and will be among the first to demonstrate effective methods of retaining digital cohorts for HIV as well as other health conditions. Study findings will also help identify multilevel factors that contribute to non-VS in the Deep South, thereby elucidating future areas for intervention, and will directly lead to a follow- up R-level application.
项目总结

项目成果

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David S Batey其他文献

David S Batey的其他文献

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{{ truncateString('David S Batey', 18)}}的其他基金

Promoting Viral Suppression through the CHAMPS+ Intervention in the Deep South
通过 CHAMPS 干预南部腹地促进病毒抑制
  • 批准号:
    10819823
  • 财政年份:
    2023
  • 资助金额:
    $ 127.31万
  • 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
  • 批准号:
    10569099
  • 财政年份:
    2021
  • 资助金额:
    $ 127.31万
  • 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
  • 批准号:
    10161462
  • 财政年份:
    2021
  • 资助金额:
    $ 127.31万
  • 项目类别:
Harnessing Social Network Support to Improve Retention in Care and Viral Suppression among Young Black Men in Chicago and Alabama: A Hybrid Type I Effectiveness-Implementation Trial of Project nGage
利用社交网络支持改善芝加哥和阿拉巴马州年轻黑人的护理保留和病毒抑制:nGage 项目的 I 型混合有效性实施试验
  • 批准号:
    10378666
  • 财政年份:
    2021
  • 资助金额:
    $ 127.31万
  • 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
  • 批准号:
    10427397
  • 财政年份:
    2020
  • 资助金额:
    $ 127.31万
  • 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
  • 批准号:
    10632026
  • 财政年份:
    2020
  • 资助金额:
    $ 127.31万
  • 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
  • 批准号:
    10164175
  • 财政年份:
    2020
  • 资助金额:
    $ 127.31万
  • 项目类别:
CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings
CHAMPS:社区卫生工作者在两个高度优先环境中对艾滋病毒感染者进行干预的随机试验
  • 批准号:
    10269043
  • 财政年份:
    2020
  • 资助金额:
    $ 127.31万
  • 项目类别:
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
南方腹地从艾滋病毒诊断到病毒抑制的时间地理差异:加速治疗启动的路线图
  • 批准号:
    10305677
  • 财政年份:
    2018
  • 资助金额:
    $ 127.31万
  • 项目类别:
Geographic Variability in Time from HIV Diagnosis to Viral Suppression in the Deep South: A Roadmap to Accelerated Treatment Initiation
南方腹地从艾滋病毒诊断到病毒抑制的时间地理差异:加速治疗启动的路线图
  • 批准号:
    10523522
  • 财政年份:
    2018
  • 资助金额:
    $ 127.31万
  • 项目类别:

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