eSTEP: An integrated mHealth intervention to engage high-risk individuals along the full PrEP care continuum

eSTEP:一种综合移动医疗干预措施,让高危人群参与整个 PrEP 护理连续过程

基本信息

  • 批准号:
    10675096
  • 负责人:
  • 金额:
    $ 23.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Pre-exposure prophylaxis (PrEP) is highly-effective in preventing new HIV infections among gay, bisexual and other men who have sex with men (GBMSM) and transgender women (TW), but relies on engaging these high- risk communities at multiple steps along the PrEP continuum of care. Studies show that a minority of PrEP- eligible GBMSM are taking PrEP, and TW are less likely than GBMSM to have heard of PrEP, talked with their provider about PrEP, used PrEP in the past 6 months, and been adherent to PrEP. An existing HIV testing and PrEP program led by members of our study team in San Diego, CA found that over 60% of GBMSM and TW participants eligible for PrEP were not interested in starting it; of those who did start PrEP, only 5.8% remained on PrEP after 3 months. Clearly, innovative interventions that optimize the PrEP continuum of care for diverse GBMSM and TW are needed. We propose here a theoretically-grounded (in the IMB model), effective, accessible and sustainable mHealth PrEP care continuum intervention for GBMSM and TW, called eSTEP (Electronic Support To Engage with PrEP). The eSTEP WebApp will be tailored by sexuality and gender status and include a set of interactive components delivered before in-person HIV testing (e.g., PrEP information on the benefits of PrEP) and after the participant tests HIV-negative and agrees to start PrEP (e.g., adherence self-monitoring). Aim 1: Use an iterative development process to gain feedback on eSTEP content and features through focus groups with GBMSM and TW and a community advisory board (CAB). 6 focus groups with 18-45 year-old GBMSM and TW (6 participants/group; > 50% Black/Latinx) will be conducted at 3 key points in the intervention development cycle to create the tailored (separately for GBMSM & TW) IMB-related content and features of eSTEP. A CAB of GBMSM (n=3) and TW (n=3) will be established to provide guidance between rounds of focus groups. Aim 1 will culminate in usability testing among 3 GBMSM and 3 TW to finalize eSTEP. Aim 2: Conduct a pilot randomized controlled trial of eSTEP to assess its feasibility, acceptability, and preliminary impact among GBMSM and TW in preparation for a large-scale R01. 120 (50% racial/ethnic minority) GBMSM (n=85) and TW (n=35) who report risk factors that qualify for PrEP eligibility will be randomized (2:1) to the eSTEP intervention (n=80) or a usual HIV testing control (n=40). The eSTEP group will have immediate access to pre-HIV testing components. All study participants will be offered free in-person HIV testing and, if eligible, PrEP at a university-based HIV prevention and treatment clinic. eSTEP participants who begin PrEP will unlock PrEP adherence and persistence components. Follow-up study visits will be conducted at 3- and 6-months to collect biological, clinical, and self-reported outcomes to assess eSTEP’s feasibility, acceptability, and preliminary outcomes (HIV test completion, PrEP initiation, PrEP adherence, and PrEP appointment attendance). Finally, 10 GBMSM and 10 TW in the intervention arm will participate in an exit interview to gain feedback on eSTEP in anticipation of a large-scale R01 study.
暴露前预防(PrEP)在预防同性恋、双性恋和同性恋者中新的艾滋病毒感染方面非常有效

项目成果

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Keith Joseph Horvath其他文献

Keith Joseph Horvath的其他文献

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{{ truncateString('Keith Joseph Horvath', 18)}}的其他基金

eSTEP: An integrated mHealth intervention to engage high-risk individuals along the full PrEP care continuum
eSTEP:一种综合移动医疗干预措施,让高危人群参与整个 PrEP 护理连续过程
  • 批准号:
    10556195
  • 财政年份:
    2022
  • 资助金额:
    $ 23.08万
  • 项目类别:
Using EMA to developmentally tailor an intervention to support on-demand PrEP among YMSM
使用 EMA 制定干预措施以支持 YMSM 中的按需 PrEP
  • 批准号:
    10250523
  • 财政年份:
    2020
  • 资助金额:
    $ 23.08万
  • 项目类别:
LinkPositively: A Technology-Delivered Peer Navigation and Social Networking Intervention to Improve HIV Care Across the Continuum for Black Women Affected by Interpersonal Violence
LinkPositively:技术提供的同伴导航和社交网络干预措施可改善受人际暴力影响的黑人妇女的艾滋病毒护理
  • 批准号:
    9913297
  • 财政年份:
    2019
  • 资助金额:
    $ 23.08万
  • 项目类别:
LinkPositively: A Technology-Delivered Peer Navigation and Social Networking Intervention to Improve HIV Care Across the Continuum for Black Women Affected by Interpersonal Violence
LinkPositively:技术提供的同伴导航和社交网络干预措施可改善受人际暴力影响的黑人妇女的艾滋病毒护理
  • 批准号:
    10292458
  • 财政年份:
    2019
  • 资助金额:
    $ 23.08万
  • 项目类别:
LinkPositively: A Technology-Delivered Peer Navigation and Social Networking Intervention to Improve HIV Care Across the Continuum for Black Women Affected by Interpersonal Violence
LinkPositively:技术提供的同伴导航和社交网络干预措施可改善受人际暴力影响的黑人妇女的艾滋病毒护理
  • 批准号:
    10064028
  • 财政年份:
    2019
  • 资助金额:
    $ 23.08万
  • 项目类别:
A Technology-Delivered Peer-to-Peer Support ART Adherence Intervention for HIV+ Adults
一种通过技术提供的点对点支持,针对艾滋病毒成人的 ART 依从干预
  • 批准号:
    8943049
  • 财政年份:
    2015
  • 资助金额:
    $ 23.08万
  • 项目类别:
A Technology-Delivered Peer-to-Peer Support ART Adherence Intervention for HIV+ Adults
通过技术提供点对点支持的 ART 依从性艾滋病毒成人干预措施
  • 批准号:
    9273492
  • 财政年份:
    2015
  • 资助金额:
    $ 23.08万
  • 项目类别:
A Mobile App to Increase Routine HIV Testing Among High-Risk Diverse MSM
一款可增加高风险多元化 MSM 常规 HIV 检测的移动应用程序
  • 批准号:
    8898231
  • 财政年份:
    2014
  • 资助金额:
    $ 23.08万
  • 项目类别:
A Mobile App to Increase Routine HIV Testing Among High-Risk Diverse MSM
一款可增加高风险多元化 MSM 常规 HIV 检测的移动应用程序
  • 批准号:
    8788610
  • 财政年份:
    2014
  • 资助金额:
    $ 23.08万
  • 项目类别:
A Mobile App to Increase Routine HIV Testing Among High-Risk Diverse MSM
一款可增加高风险多元化 MSM 常规 HIV 检测的移动应用程序
  • 批准号:
    9110351
  • 财政年份:
    2014
  • 资助金额:
    $ 23.08万
  • 项目类别:

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