Training in Immunological Mechanisms
Training in Immunological Mechanisms
批准号:
10675443
负责人:
Michael Croft
金额:
$25.73万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-08-01 至 2026-07-31
关键词:
中文摘要
摘要
该计划将培养博士后研究科学家在免疫机制有关的发展
以及自身免疫、炎症和传染病以及癌症的治疗。拉霍亚的节目
免疫学研究所(LJI)将包括来自LJI的20名教师,他们的专业知识是免疫细胞
与糖尿病、炎症性肠病、多发性硬化症、哮喘
动脉粥样硬化、特应性皮炎、登革热、HIV、巨细胞病毒、结核病、埃博拉和免疫肿瘤学。
每位教师导师在免疫学或免疫疾病领域都是国际公认的,
拥有丰富的同行评审研究经验和跟踪记录。该计划将开放给博士,医学博士,
以及对免疫系统的基础和应用研究感兴趣的MD/PhD科学家。培训计划
将包括12-24个月的实验室工作经验,在一个
导师或几个导师从事与免疫治疗相关的问题。本文首先介绍了
教师导师是不同的,但共同的主题集中在生物学的主要细胞的
免疫系统,包括T细胞、B细胞、NKT细胞、巨噬细胞、树突细胞、嗜中性粒细胞等。
培训计划将代表一个跨学科的方法,每个受训者都接触到切割
边缘和国家的最先进的免疫技术和系统,使基础和翻译
免疫系统的发现我们现在和过去的学员都有出色的研究记录
成就。将在全国范围内招募新学员,并努力招募和留住
特殊少数群体、妇女和弱势候选人。学员将根据其先前的
学术表现、研究经验、出版物、面试和导师的推荐。
学员将参加机构研讨会、期刊俱乐部、课程和免疫学会议
旨在扩大他们对免疫学和免疫疾病的理解。所有学员
将在负责任的研究行为和科学诚信的原则指导。的目标
该计划旨在培养全面发展的免疫学家,他们可以填补急需的学术空白。
职位,谁可以竞争并成功获得独立的研究赠款,谁可以
促进生物技术和制药方法,旨在治疗免疫相关疾病。
英文摘要
Abstract
This program will train postdoctoral research scientists in immunological mechanisms related to development
and treatment of Autoimmune, Inflammatory, and Infectious Disease, and Cancer. The program at La Jolla
Institute for Immunology (LJI) will involve 20 faculty members from LJI whose expertise is in immune cell
function that relates to diseases such as diabetes, inflammatory bowel disease, multiple sclerosis, asthma,
atherosclerosis, atopic dermatitis, dengue, HIV, cytomegalovirus, tuberculosis, ebola, and immuno-oncology.
Each faculty mentor is internationally recognized in the field of immunology or immunological disease and each
has substantial peer-reviewed research experience and track records. The program will be open to PhD, MD,
and MD/PhD scientists interested in basic and applied research of the immune system. The training program
will consist of a bench research laboratory experience of 12-24 months, under the close supervision of a
mentor or several mentors working on problems relevant to immunotherapy. The research backgrounds of the
faculty mentors are diverse, but with common themes centered on the biology of the primary cells of the
immune system, including T cells, B cells, NKT cells, macrophages, dendritic cells, neutrophils, and others.
The training program will then represent an interdisciplinary approach where each trainee is exposed to cutting
edge and state-of-the-art immunological techniques and systems for making fundamental and translational
discoveries of the immune system. Our current and past trainees have excellent records of research
accomplishments. New trainees will be recruited nationwide and efforts will be made to recruit and retain
exceptional minority, women, and disadvantaged candidates. Trainees will be chosen on the basis of their prior
academic performance, research experience, publications, interviews, and recommendations from supervisors.
Trainees will participate in institutional seminars, journal clubs, courses, and immunology conferences
designed to expand the breadth of their understanding of immunology and immunological disease. All trainees
will be instructed in the principles of responsible conduct of research and scientific integrity. The goals of the
program are to foster the development of well-rounded immunologists who can fill much needed academic
positions, who can compete and be successful in obtaining independent research grants, and who can
contribute to biotechnology and pharmaceutical approaches, aimed at treatment of immune-related diseases.
期刊论文(20)
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DOI:
10.3390/ijms23179875
发表时间:
2022-08-30
期刊:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子:
5.6
作者:
[Saigusa, Ryosuke, Vallejo, Jenifer, Gulati, Rishab, Suthahar, Sujit Silas Armstrong, Suryawanshi, Vasantika, Alimadadi, Ahmad, Makings, Jeffrey, Durant, Christopher P., Freuchet, Antoine, Roy, Payel, Ghosheh, Yanal, Pandori, William, Pattarabanjird, Tanyaporn, Drago, Fabrizio, Taylor, Angela, McNamara, Coleen A., Shemesh, Avishai, Lanier, Lewis L., Hedrick, Catherine C., Ley, Klaus]
通讯作者:
Ley, Klaus
DOI:
10.1016/j.jns.2022.120510
发表时间:
2023-01-15
期刊:
JOURNAL OF THE NEUROLOGICAL SCIENCES
影响因子:
4.4
作者:
[Williams, Gregory P., Muskat, Kaylin, Frazier, April, Xu, Yaqian, Mateus, Jose, Grifoni, Alba, Antunes, Ricardo da Silva, Weiskopf, Daniela, Amara, Amy W., Standaert, David G., Goldman, Jennifer G., Litvan, Irene, Alcalay, Roy N., Sulzer, David, Arlehamn, Cecilia S. Lindestam, Sette, Alessandro]
通讯作者:
Sette, Alessandro
DOI:
10.4049/jimmunol.1900245
发表时间:
2019-12-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[Gaddis DE, Padgett LE, Wu R, Hedrick CC]
通讯作者:
Hedrick CC
Preparation of Whole Bone Marrow for Mass Cytometry Analysis of Neutrophil-lineage Cells.
制备全骨髓用于中性粒细胞谱系细胞的质量细胞计数分析。
DOI:
10.3791/59617
发表时间:
2019
期刊:
Journal of visualized experiments : JoVE
影响因子:
--
作者:
[Zhu,YanfangPeipei, Padgett,Lindsey, Dinh,HuyQ, Marcovecchio,Paola, Wu,Runpei, Hinz,Denise, Kim,Cheryl, Hedrick,CatherineC]
通讯作者:
Hedrick,CatherineC
DOI:
10.1038/s41556-023-01152-6
发表时间:
2023-06
期刊:
Nature cell biology
影响因子:
21.3
作者:
[]
通讯作者:
共 13 条
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资助金额:$39.2万
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A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy
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资助金额:$52.31万
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财政年份:2018
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依托单位:
TWEAK and Skin Inflammation
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批准号:9910059
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资助金额:$39.6万
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财政年份:2018
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A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy
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批准号:10310411
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资助金额:$51.26万
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资助金额:$38.41万
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依托单位:
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项目类别:
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资助金额:$45.0万
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财政年份:2018
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批准号:9321444
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财政年份:2016
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Training in Immunological Mechanisms
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资助金额:$33.27万
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财政年份:2016
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依托单位:
Novel PTPRD interaction Controlling T cell Responsiveness
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批准号:9077779
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资助金额:$26.55万
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财政年份:2016
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Structural Characterization of 4-1BB-Galectin-9 Complexes
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Control of Airway Tolerance
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Control of Airway Tolerance
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批准号:8661698
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依托单位:
Control of Airway Tolerance
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批准号:9267076
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依托单位:
Novel costimulatory pathways required for T cell regulation
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资助金额:$43.81万
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负责人:Michael Croft
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Control of Airway Tolerance
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资助金额:$44.25万
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Control of Airway Tolerance
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资助金额:$44.25万
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Novel costimulatory pathways required for T cell regulation
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海外基金