Pathology & Genomics
病理
基本信息
- 批准号:10673949
- 负责人:
- 金额:$ 30.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AllelesAnatomyAntibodiesAreaBiochemical PathwayBiochemical ProcessBiologicalBiological AssayBiological MarkersCancer BiologyCancer CenterCaringCellsCertificationClinicalClinical PathologyClinical TreatmentComplementCustomDana-Farber Cancer InstituteDatabasesDetection of Minimal Residual DiseaseDevelopmentDiagnosisDiseaseEpidermal Growth Factor ReceptorErlotinibEtiologyExpression ProfilingGefitinibGene Expression ProfilingGeneticGenomicsGenotypeGoalsHistologicHybridsImageImmuneImmunofluorescence ImmunologicImmunohistochemistryImmunophenotypingIn SituIndividualInternationalInterventionIonsKnowledgeLaboratoriesMalignant NeoplasmsMalignant neoplasm of lungManualsMassive Parallel SequencingMeasuresMedicineMicroscopicMolecularMolecular GeneticsMonitorMultiplexed Ion Beam ImagingMutationOncogenicPathologistPathologyPatient MonitoringPatient SelectionPatientsPeriodicityPlasmaProceduresProteinsProtocols documentationQuality ControlRNA analysisROS1 geneReproduction sporesResearchResearch PersonnelResourcesSamplingScanningSelection for TreatmentsSeminalServicesSlideSpecimenStructure of parenchyma of lungSupervisionSystemTechniquesTechnologyTissue BanksTissue MicroarrayTissue SampleTissuesTranscriptTranslational ResearchTumor TissueValidationVertebral columnWorkautomated image analysisautomated segmentationcancer cellcrizotinibdesigndetection assayimmune cell infiltrateimmunoregulationimprovedinhibitorinnovationmolecular pathologynano-stringnext generation sequencingnovelnovel markerprotein biomarkersprotein expressionquality assuranceresponsesample collectionsequencing platformskillsstandard of caretranscriptomicstreatment and outcometumortumor DNAtumor microenvironment
项目摘要
Project Summary:
The Integrated Pathology and Genomics Core provides state-of-the-art analytic services for lung cancer samples
spanning the full spectrum from initial sample handling and processing, to microscopic analysis by certified
anatomic pathologists, to immunophenotypic analysis, to molecular genetic and genomic analysis. This work
constitutes the backbone of lung cancer management, and enables the diagnosis and proper treatment selection
for patients with lung cancers of all types, and also enables research into cancer biology, etiology, and
management. Our pathology core has supported work that has led to major advances in the understanding of
lung cancer biology, and associated management thereof, including seminal discoveries of the importance of
mutations in EGFR, ALK, ROS1, and MET in lung cancer, the diagnosis and management of which have become
the international standard-of-care in this area of medicine. In the same manner, we intend to continue our work
to advance the understanding and care of lung cancer, by supporting the new projects proposed herein, with a
combination of standard-of-care and innovative new cutting-edge technologies.
In this SPORE proposal, we will support each of the proposed projects with a combination of standard-of-care
clinical pathology services - such as histologic characterization of tumors, immunohistochemical assessment of
protein expression, and massively parallel sequencing of tumor DNA - and innovative new techniques. Among
the innovative new techniques to be deployed for this project are customized allele-specific PCR assays for
individual fusion transcripts to enable ultrasensitive monitoring of cell-free circulating ALK rearrangements in
plasma samples, cyclic immunofluorescence and transcriptomics for simultaneous in situ spatial expression of
multiple proteins and transcripts involved in various biochemical pathways, and multiplexed ion beam imaging
to provide high-order assessment of immune cell infiltrates within and adjacent to cancers.
项目概要:
整合病理学和基因组学核心为肺癌样本提供最先进的分析服务
从最初的样品处理和加工到显微镜分析,
解剖病理学家,免疫表型分析,分子遗传学和基因组分析。这项工作
构成肺癌管理的支柱,并实现诊断和适当的治疗选择
对于所有类型的肺癌患者,还可以研究癌症生物学,病因学,
管理我们的病理学核心支持的工作,导致了重大进展的理解,
肺癌生物学及其相关管理,包括以下重要性的开创性发现:
肺癌中EGFR、ALK、ROS 1和MET的突变,其诊断和管理已成为
这一医学领域的国际护理标准。同样,我们打算继续我们的工作,
通过支持本文提出的新项目,
结合标准护理和创新的新尖端技术。
在此SPORE提案中,我们将支持每个拟议项目,并结合标准护理
临床病理学服务-如肿瘤的组织学特征,
蛋白质表达和肿瘤DNA的大规模平行测序-以及创新的新技术。之间
该项目将采用的创新性新技术是定制的等位基因特异性PCR检测,
单个融合转录物,能够超灵敏地监测无细胞循环ALK重排,
血浆样品,循环免疫荧光和转录组学,用于同时原位空间表达
多种蛋白质和转录物参与各种生化途径,以及多路离子束成像
以提供癌症内和癌旁免疫细胞浸润的高级评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David A Barbie其他文献
David A Barbie的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David A Barbie', 18)}}的其他基金
Dana Farber/Harvard Cancer Center SPORE in Lung Cancer
Dana Farber/哈佛大学癌症中心 SPORE 在肺癌中的应用
- 批准号:
10673920 - 财政年份:2022
- 资助金额:
$ 30.6万 - 项目类别:
Development of Physiologic Tissue Models to Assess Tumor Explant Response to Immune Checkpoint Blockade
开发生理组织模型来评估肿瘤外植体对免疫检查点封锁的反应
- 批准号:
10250392 - 财政年份:2017
- 资助金额:
$ 30.6万 - 项目类别:
Targeting the cytokine circuitry of KRAS-driven lung cancer
靶向 KRAS 驱动肺癌的细胞因子回路
- 批准号:
10424442 - 财政年份:2015
- 资助金额:
$ 30.6万 - 项目类别:
Targeting the cytokine circuitry of KRAS-driven lung cancer
靶向 KRAS 驱动肺癌的细胞因子回路
- 批准号:
9042321 - 财政年份:2015
- 资助金额:
$ 30.6万 - 项目类别:
Targeting the cytokine circuitry of KRAS-driven lung cancer
靶向 KRAS 驱动肺癌的细胞因子回路
- 批准号:
10172854 - 财政年份:2015
- 资助金额:
$ 30.6万 - 项目类别:
Targeting the cytokine circuitry of KRAS-driven lung cancer
靶向 KRAS 驱动肺癌的细胞因子回路
- 批准号:
10670932 - 财政年份:2015
- 资助金额:
$ 30.6万 - 项目类别:
Targeting the cytokine circuitry of KRAS-driven lung cancer
靶向 KRAS 驱动肺癌的细胞因子回路
- 批准号:
9263834 - 财政年份:2015
- 资助金额:
$ 30.6万 - 项目类别:
Synthetic-Lethal-Based Targeted Therapy for Oncogenic KRAS-Driven Cancer
针对 KRAS 驱动的致癌癌症的合成致死靶向治疗
- 批准号:
8317974 - 财政年份:2010
- 资助金额:
$ 30.6万 - 项目类别:
相似海外基金
Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
- 批准号:
EP/Z000882/1 - 财政年份:2024
- 资助金额:
$ 30.6万 - 项目类别:
Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
- 批准号:
BB/Y513908/1 - 财政年份:2024
- 资助金额:
$ 30.6万 - 项目类别:
Research Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
- 批准号:
23K11917 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
- 批准号:
10555809 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
- 批准号:
2825967 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Studentship
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
- 批准号:
BB/X013227/1 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
- 批准号:
2235348 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Standard Grant
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
- 批准号:
10761060 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
- 批准号:
10751126 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
The Anatomy of Online Reviews: Evidence from the Steam Store
在线评论剖析:来自 Steam 商店的证据
- 批准号:
2872725 - 财政年份:2023
- 资助金额:
$ 30.6万 - 项目类别:
Studentship