Development and assessment of an HIV disclosure intervention for men in Uganda

乌干达男性艾滋病毒披露干预措施的制定和评估

基本信息

批准号：
10676867
负责人：
Pooja Rao Chitneni
金额：
$ 19.34万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-04 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10676867
关键词：
AIDS prevention Adherence Africa South of the Sahara Attention Behavior Behavior Therapy Behavioral Sciences Biometry Caring Clinical Clinical Investigator Cognitive Therapy Communication Communities Control Groups Counseling Data Dedications Development Diagnosis Disclosure Education Elements Eligibility Determination Enrollment Ensure Epidemic Epidemiology Event Family Focus Groups Funding Future Gender Goals HIV HIV risk Health Healthcare Human immunodeficiency virus test Institution Intervention Intervention Trial Interview Manuals Masculine Measures Mentors Mentorship Methods Modeling Obesity Outcome Participant Partner Notification Patient Self-Report Persons Physiological Positioning Attribute Prevention Problem Solving Process Qualitative Methods Randomized Randomized, Controlled Trials Reaction Reporting Research Research Personnel Resource-limited setting Resources Risk Risk Reduction Role playing therapy Rural STI prevention Sampling Scientist Sexual Partners Sexually Transmitted Diseases Social support Southern Africa Symptoms Training Treatment Efficacy Uganda United States National Institutes of Health Viral Viral Load result Woman Work acceptability and feasibility antiretroviral therapy behavioral clinical trial career development clinical care clinical trial analysis clinical trial implementation cohort efficacy evaluation evidence base experience improved innovation male male health meetings men novel pilot test preference primary outcome recruit sexual risk taking skills social stigma success theories therapy adherence therapy development tool transmission process treatment as prevention uptake

项目摘要

PROJECT SUMMARY Background: In sub-Saharan Africa, men consistently lag behind women along each step of the HIV care cascade and contribute to HIV transmission among women. Disclosure of HIV is a key step in prevention, however, few evidence-based resources exist to support HIV disclosure among men with HIV (MWH) in sub- Saharan Africa. Candidate: My long-term goal is to become an independent, NIH-funded clinical researcher dedicated to interventions to support HIV and sexually transmitted infection (STI) prevention and treatment in resource limited settings. Mentoring: Drs. Jessica Haberer (clinical trial implementation) and Lynn Matthews (methods for intervention development; co-primary mentors) are both successful NIH-funded investigators who have both mentored multiple NIH career development awardees. Drs. Winnie Muyindike (HIV clinical care engagement and outcomes), Andrew Mujugira (male engagement in HIV and STI care and research), Christina Psaros (behavioral science theory), Seth Kalichman (HIV disclosure and assisted partner notification), and Bethany Hedt-Gauthier (advanced clinical trial analysis and biostatistics) will provide additional focused mentorship to ensure success. Research: The goal of this proposal is to develop and test an HIV disclosure intervention focused on MWH meeting the following eligibility criteria: with STI symptoms who are either not accessing antiretroviral therapy or are accessing antiretroviral therapy but without viral suppression. In Aim 1, I will identify the unique HIV disclosure needs and preferences to support HIV disclosure through in-depth qualitative interviews with up to 30 MWH meeting eligibility criteria. In Aim 2, I will utilize the findings from Aim 1 to adapt interventions with HIV disclosure components in order to develop a novel HIV disclosure intervention focused on MWH. The intervention will be iteratively refined through focus group discussions with up to 20 participants, their sexual partners, and a community advisory board. In Aim 3, I will recruit 70 MWH meeting eligibility criteria for participation in a randomized controlled trial to pilot test the intervention against an attention-matched control group. Participants will be encouraged to bring their sexual partners for study enrollment and HIV testing and counseling. Up to 15 MWH and their sexual partners will be invited for qualitative interviews. I will measure the primary outcomes of acceptability and feasibility by mixed methods. Training: To achieve my aims and gain research independence, I require additional training in: 1) behavioral science theory for behavioral intervention development and assessment 2) methods for behavioral intervention development, and 3) advanced behavioral clinical trial analysis. Based on my previous research experience and success, support from an exceptional mentoring team, strong institutional commitment, and an innovative research plan, I am well-positioned to become an independent clinical investigator focused on HIV and STI prevention and treatment in resource limited settings.

项目摘要背景：在撒哈拉以南非洲，男人始终落后于艾滋病毒护理的每个步骤级联并为妇女的艾滋病毒传播做出贡献。 HIV披露是预防的关键步骤，但是，很少有基于证据的资源能够支持艾滋病毒（MWH）的艾滋病毒披露。撒哈拉非洲。候选人：我的长期目标是成为一名独立的NIH资助的临床研究人员致力于支持艾滋病毒和性传播感染（STI）预防和治疗的干预措施资源有限的设置。指导：博士。杰西卡·哈伯（Jessica Haberer）（临床试验实施）和林恩·马修斯（Lynn Matthews）（干预开发方法；共同主要导师）都是成功的NIH资助的调查员都指导了多个NIH职业发展获奖者。博士。 Winnie Muyindike（HIV临床护理参与和结果），安德鲁·穆乔吉拉（Andrew Mujugira）（男性参与艾滋病毒和STI护理与研究），克里斯蒂娜 PSAROS（行为科学理论），Seth Kalichman（HIV披露和辅助合作伙伴通知），以及 Bethany Hedt-Gauthier（高级临床试验分析和生物统计学）将提供额外的重点指导以确保成功。研究：该提案的目的是开发和测试HIV披露干预旨在满足以下资格标准的MWH的干预措施：具有不可能的性传播症状接受抗逆转录病毒疗法或正在接受抗逆转录病毒疗法，但没有病毒抑制。在AIM 1中，我将确定独特的HIV披露需求和偏好，以支持艾滋病毒披露。定性访谈最多30兆瓦时满足资格标准。在AIM 2中，我将利用AIM的发现 1以适应HIV披露组件的干预措施以开发新的HIV披露干预重点是MWH。干预将通过焦点小组讨论与最多20名参与者，他们的性伴侣和一个社区顾问委员会。在AIM 3中，我将招募70 MWH 满足参与随机对照试验的资格标准，以试行测试干预措施注意匹配对照组。将鼓励参与者带他们的性伴侣进行学习入学和艾滋病毒测试和咨询。最多15 MWH，他们的性伴侣将被邀请定性访谈。我将通过混合方法来衡量可接受性和可行性的主要结果。培训：为了实现我的目标并获得研究独立性，我需要其他培训：1）行为行为干预发展和评估的科学理论2）行为干预的方法开发和3）先进的行为临床试验分析。根据我以前的研究经验成功，由卓越的指导团队的支持，强大的机构承诺和创新研究计划，我很容易成为专注于HIV和STI的独立临床研究者在资源有限的环境中的预防和治疗。