Bioinformatics Core

阿拉斯加INBRE 4-生物信息学核心项目摘要 One Health认识到，人类健康与动物及其共享环境的健康有关。 现代生物医学研究中的这些关系使研究人员能够研究人、动物、植物和 微生物及其相互作用通过多种自下而上的“组学”方法。结果包括大规模的 实验系统中有关基因、蛋白质和代谢物的信息量，它代表一个 生物医学研究的革命性技术进步也需要新的工具来分类和 分析这些信息。AK INBRE 3生物信息学核心建立了分布式核心模型，其中 阿拉斯加的生物信息学资源通过支持获取外部资源和 来自阿拉斯加大学网络以外的培训。AK INBRE 4生物信息学的总体目标 核心是为研究人员和研究人员提供最先进的生物信息学和生物统计学服务和培训 学生们。该核心将建立在成功的AK INBRE 3核心的基础上，为阿拉斯加提供增强的支持 基础设施，包括大规模并行“下一代”测序和高性能计算，以及 通过在阿拉斯加用户群体中促进新兴生物信息学技术的发展。核心活动 将利用UA系统内的生物信息学资源，并为调查人员提供资金和指导 利用外部生物信息学资源在阿拉斯加建设生物医学研究能力。《核心》 部署分布式模式，在下一代高性能计算中利用阿拉斯加的资源 测序和生物统计学，资助AK INBRE科学家使用外部资源和 训练。总体目标是为生物信息学和生物统计学提供最先进的服务和培训 对于AK INBRE社区，核心将执行以下具体目标：1)提供访问 生物信息学技术和数据获取，通过支持当地设备和专门知识以及 获得阿拉斯加以外的资源；2)支持生物信息学和生物统计学实验设计和 通过获得阿拉斯加的专业和外部专业知识进行数据分析；3)支持职业 为学生、博士后研究员、教职员工和高级研究人员提供开发和生物信息学培训 AK INBRE网络，通过在阿拉斯加的讲习班和课程开发以及通过 支持外部培训；4)促进新兴生物信息学技术的发展 加强INBRE One Health研究。

Alaska INBRE 4 - BIOINFORMATICS CORE PROJECT SUMMARY One Health recognizes that human health is connected to the health of animals and their shared environment. These relationships in modern biomedical research enable researchers to study people, animals, plants, and microbes and their interactions through multiple bottom-up “omics” methods. The results include massive amounts of information about genes, proteins, and metabolites in an experimental system, which represents a revolutionary technological advancement in biomedical research that also necessitates new tools to sort and analyze the information. The AK INBRE 3 Bioinformatics Core established a distributed core model where Alaska-based bioinformatics resources were augmented by support for access to external resources and training from outside the University of Alaska network. The overall goals of the AK INBRE 4 Bioinformatics Core are to provide state-of-the art services and training in bioinformatics and biostatistics for investigators and students. The core will build on the successful AK INBRE 3 Core by providing enhanced support for Alaska infrastructure, including massively-parallel “next-gen” sequencing and high performance computing, as well as by promoting development of emerging bioinformatics technologies in the Alaska user group. Core activities will leverage bioinformatics resources within the UA system and provide funding and guidance to investigators to capitalize on external bioinformatics resources to build biomedical research capacity in Alaska. The Core deploys a distributed model that leverages Alaska-based resources in high-performance computing, next-gen sequencing, and biostatistics with funding support for AK INBRE scientists to use external resources and training. With an overall goal to provide state-of-the art services and training for bioinformatics and biostatistics for the AK INBRE community, the core will execute the following specific aims: 1) Provide access to bioinformatics technology and data acquisition through the support of local equipment and expertise as well as access to resources outside of Alaska; 2) Support bioinformatics and biostatistics experimental design and data analysis through access to specialized Alaska-based and external expertise; 3) Support career development and bioinformatics training for students, postdoctoral fellows, faculty and senior researchers in the AK INBRE network through Alaska-based workshops and curriculum development, as well as through support for external training; 4) Promote the development of emerging bioinformatics technologies that enhance INBRE One Health research.