Bioinformatics Core

阿拉斯加州INBRE 4 -生物信息学核心项目摘要 One Health认识到人类健康与动物及其共享环境的健康息息相关。 现代生物医学研究中的这些关系使研究人员能够研究人、动物、植物， 微生物及其相互作用通过多种自下而上的“组学”方法。结果包括大量 大量关于实验系统中基因、蛋白质和代谢物的信息， 生物医学研究的革命性技术进步，也需要新的工具来分类， 分析信息。AK INBRE 3生物信息学核心建立了分布式核心模型， 通过支持获取外部资源， 来自阿拉斯加大学网络之外的培训。AK INBRE 4生物信息学的总体目标 核心是为研究者提供最先进的生物信息学和生物统计学服务和培训， 学生该核心将建立在成功的AK INBRE 3核心的基础上，为阿拉斯加提供更强的支持 基础设施，包括并行的“下一代”测序和高性能计算，以及 通过促进阿拉斯加用户群中新兴生物信息学技术的发展。核心活动 将利用普遍获得系统内的生物信息学资源，并为研究人员提供资金和指导 利用外部生物信息学资源，在阿拉斯加建立生物医学研究能力。核心 部署了一个分布式模型，利用阿拉斯加的资源，在高性能计算，下一代 测序和生物统计，为AK INBRE科学家提供资金支持，以利用外部资源， 训练总体目标是为生物信息学和生物统计学提供最先进的服务和培训 对于AK INBRE社区，核心将执行以下具体目标：1）提供访问 生物信息技术和数据采集，通过当地设备和专业知识的支持，以及 2）支持生物信息学和生物统计学实验设计， 通过获得专门的阿拉斯加和外部专家的数据分析; 3）支持职业生涯 为学生，博士后研究员，教师和高级研究人员提供生物信息学和生物信息学培训， AK INBRE网络，通过设在阿拉斯加的讲习班和课程开发，以及通过 支持外部培训; 4）促进新兴生物信息技术的发展， 加强INBRE One Health研究。

Alaska INBRE 4 - BIOINFORMATICS CORE PROJECT SUMMARY One Health recognizes that human health is connected to the health of animals and their shared environment. These relationships in modern biomedical research enable researchers to study people, animals, plants, and microbes and their interactions through multiple bottom-up “omics” methods. The results include massive amounts of information about genes, proteins, and metabolites in an experimental system, which represents a revolutionary technological advancement in biomedical research that also necessitates new tools to sort and analyze the information. The AK INBRE 3 Bioinformatics Core established a distributed core model where Alaska-based bioinformatics resources were augmented by support for access to external resources and training from outside the University of Alaska network. The overall goals of the AK INBRE 4 Bioinformatics Core are to provide state-of-the art services and training in bioinformatics and biostatistics for investigators and students. The core will build on the successful AK INBRE 3 Core by providing enhanced support for Alaska infrastructure, including massively-parallel “next-gen” sequencing and high performance computing, as well as by promoting development of emerging bioinformatics technologies in the Alaska user group. Core activities will leverage bioinformatics resources within the UA system and provide funding and guidance to investigators to capitalize on external bioinformatics resources to build biomedical research capacity in Alaska. The Core deploys a distributed model that leverages Alaska-based resources in high-performance computing, next-gen sequencing, and biostatistics with funding support for AK INBRE scientists to use external resources and training. With an overall goal to provide state-of-the art services and training for bioinformatics and biostatistics for the AK INBRE community, the core will execute the following specific aims: 1) Provide access to bioinformatics technology and data acquisition through the support of local equipment and expertise as well as access to resources outside of Alaska; 2) Support bioinformatics and biostatistics experimental design and data analysis through access to specialized Alaska-based and external expertise; 3) Support career development and bioinformatics training for students, postdoctoral fellows, faculty and senior researchers in the AK INBRE network through Alaska-based workshops and curriculum development, as well as through support for external training; 4) Promote the development of emerging bioinformatics technologies that enhance INBRE One Health research.