Using Modifiable Risk Factors to Predict Inferior Care and Survival after Breast Cancer Diagnosis: A Novel Approach to Addressing Health Disparities

使用可改变的风险因素来预测乳腺癌诊断后的不良护理和生存：解决健康差异的新方法

• 批准号: 10681334
• 负责人: Oluwadamilola M. Fayanju
• 金额: $ 19.44万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-06 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681334
• 关键词: Address; Adherence; Age; American Joint Committee on Cancer; Award; Biological; Biology; Breast; Breast Cancer Patient; Breast Cancer Risk Factor; Breast Cancer Treatment; Breast Cancer survivor; Caring; Cellular Phone; Cessation of life; Characteristics; Clinic; Cost Savings; Data; Data Collection; Data Set; Databases; Development; Diagnosis; Dimensions; Disease; Disparity; Ethnic Origin; Female Breast Carcinoma; Focus Groups; Future; Genomics; Geographic Locations; Guidelines; Health system; Healthcare; Healthcare Systems; High Risk Woman; Individual; Inferior; Institution; Interdisciplinary Study; Intervention; Interview; Life; Malignant Neoplasms; Measures; Modeling; Modification; National Comprehensive Cancer Network; Odds Ratio; Oncologist; Online Systems; Outcome; Patient Care; Patient Outcomes Assessments; Patients; Positioning Attribute; Primary Care; Prognosis; Provider; Quality of Care; Race; Recurrence; Recurrent Malignant Neoplasm; Research; Research Personnel; Resources; Risk; Risk Factors; Secure; Socioeconomic Status; Staging; Sterile coverings; System; Tablets; Testing; Time; Tobacco use; United States; United States Department of Veterans Affairs; Validation; Veterans Health Administration; Woman; breast cancer diagnosis; cancer care; cancer recurrence; clinical decision-making; cohort; cost; design; glycemic control; health disparity; improved; improved outcome; indexing; instrument; malignant breast neoplasm; modifiable risk; mortality; neoplasm registry; novel strategies; patient home care; precision medicine; predictive modeling; prognostication; programs; prospective; psychosocial; response; risk prediction model; simulation; tool; treatment and outcome; treatment disparity

RESEARCH SUMMARY / ABSTRACT Despite overall declines in breast cancer mortality in the United States, significant disparities in breast cancer treatment and outcomes persist. Access-related, biological, psychosocial, and provider-specific factors previously demonstrated to be associated with disparities after breast cancer diagnosis are, on the whole, static systemic or individual features that are difficult or impossible to change. As an alternative approach to addressing disparities in breast cancer, we propose creating a risk prediction model for Breast cancer Risk of Inferior Survival and Care (BRISC) that incorporates dynamic, modifiable risk factors to identify women at greatest risk for compromised care and worse survival after diagnosis with breast cancer. After development and validation, we will use the BRISC model to conduct statistical simulations and costing activities to estimate the improvement in value (i.e., outcomes achieved per health-care dollar spent) achieved via implementation of high-impact, risk-modifying interventions to facilitate receipt of guideline-concordant breast cancer treatment. Finally, we will develop a parsimonious, clinic-based data collection tool to be completed by patients and providers for the purpose of operationalizing the BRISC model as a component of routine oncologic care.

研究摘要/摘要

项目成果

Breast cancer among African American and sub-Saharan African women: a tale of global inequities.

非裔美国人和撒哈拉以南非洲妇女的乳腺癌：全球不平等的故事。

• DOI: 10.1007/s10552-022-01641-3
• 发表时间: 2022-12
• 期刊: CANCER CAUSES & CONTROL
• 影响因子: 2.3
• 作者: Gutnik, Lily;Olopade, Olufunmilayo, I;Newman, Lisa A.;Fayanju, Oluwadamilola M.
• 通讯作者: Fayanju, Oluwadamilola M.

Trends in Racial, Ethnic, and Sex Representation Among Surgical Faculty Members and Medical Students in the US, 2011-2020.

2011-2020 年美国外科教员和医学生的种族、民族和性别代表趋势。

• DOI: 10.1001/jamasurg.2021.4904
• 发表时间: 2021
• 期刊: JAMA surgery
• 影响因子: 16.9
• 作者: Yu,AliceYunziL;Iwai,Yoshiko;Thomas,SamanthaM;Beasley,GeorgiaM;Sudan,Ranjan;Fayanju,OluwadamilolaM
• 通讯作者: Fayanju,OluwadamilolaM

Disparities in Breast-Conserving Therapy Versus Mastectomy Among Asian American and Pacific Islander Women.

亚裔美国和太平洋岛民女性保乳治疗与乳房切除术的差异。

• DOI: 10.1245/s10434-023-13315-8
• 发表时间: 2023
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Patel,TejA;Dee,EdwardChristopher;Jain,Bhav;Vapiwala,Neha;Santos,PatriciaMaeG;Fayanju,OluwadamilolaM
• 通讯作者: Fayanju,OluwadamilolaM

Controversies in Breast Cancer Surgery.

• DOI: 10.1016/j.suc.2021.06.002
• 发表时间: 2021-12
• 期刊: The Surgical clinics of North America
• 作者: Gutnik L;Fayanju OM
• 通讯作者: Fayanju OM

Optimizing Sentinel Node Biopsy After Neoadjuvant Therapy: Striving to Know What We Do Not Know.

新辅助治疗后优化前哨淋巴结活检：努力了解我们不知道的事情。

• DOI: 10.1245/s10434-022-12942-x
• 发表时间: 2023
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Woodward,StevenG;Fayanju,OluwadamilolaM
• 通讯作者: Fayanju,OluwadamilolaM