Summer Undergraduate Research Fellowship in the Molecular Biology and Genomics of Human Cancer

人类癌症分子生物学和基因组学夏季本科生研究奖学金

• 批准号: 10681245
• 负责人: Jeffrey Hsu-Min Chuang
• 金额: $ 12.36万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681245
• 关键词: Area; Award; Bioethics; Bioinformatics; Biomedical Research; Cancer Biology; Cancer Center; Cancer Research Project; Career Choice; Climacteric; Communication; Communities; Computing Methodologies; Data; Databases; Dedications; Development; Education; Educational workshop; Ensure; Environment; Ethics; Etiology; Evaluation; Evolution; Faculty; Feedback; Fellowship; Fellowship Program; Foundations; Funding; Future; Genome; Genomic medicine; Genomics; Glioblastoma; Glioma; Goals; Grant; Growth; Home; Housing; Human; Immunotherapy; Individual; Institution; Internships; Laboratories; Leadership; Learning; Love; Malignant Bone Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of ovary; Medical; Mentors; Mission; Molecular; Molecular Biology; NCI-Designated Cancer Center; Occupations; Participant; Personal Growth; Plants; Privatization; Procedures; Process; Public Health; Publications; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Science; Scientific Inquiry; Scientist; Societies; Solid; Student Selections; Student recruitment; Students; Talents; The Jackson Laboratory; Training; Transportation; Travel; Underrepresented Populations; Underrepresented Students; United States National Institutes of Health; Variant; advanced analytics; analytical method; analytical tool; anticancer research; biomedical scientist; cancer genomics; cancer immunotherapy; career; career networking; cohort; collaborative environment; college; computerized tools; computing resources; cost; design; disadvantaged student; economic disparity; education research; ethical, legal, and social implication; experience; faculty mentor; formal learning; human disease; informal learning; innovation; instrumentation; interest; leukemia; life-long learning; malignant breast neoplasm; meetings; member; novel; outreach; peer; personalized cancer therapy; programs; recruit; role model; scientific literacy; summer research; summer student; symposium; undergraduate education; undergraduate research; undergraduate student

PROJECT SUMMARY / ABSTRACT The long-term goal of the proposed program is to establish a summer undergraduate research fellowship in the molecular biology and genomics of human cancer at The Jackson Laboratory for Genomic Medicine (JAX-GM) in Farmington, CT that will support the need for enhanced education in cancer research and genomics for the future biomedical workforce. This proposed program will function as a defined cohort within the existing JAX Summer Student Program (SSP). The Jackson Laboratory is a NCI-designated Cancer Center, and JAX-GM provides a collaborative, highly innovative research environment of scientists with diverse cancer expertise that will support the following aims of this program: (1) Provide an authentic and mentored research experience. JAX-GM will recruit ten students to join a cutting-edge, collaborative research team using molecular and computational methods to investigate the etiology and evolution of human breast, ovarian, bone, and brain cancers, leukemia, cancer immunotherapy, and genome structural variation and instability. (2) Promote diversity in science. The participants will be chosen through a competitive, nationwide application process, and members of underrepresented groups will be actively recruited through targeted national outreach. Each intern will receive a full fellowship including subsistence, round-trip transportation, research supplies, and funds to offset the cost of housing. These funds will enable economically disadvantaged students to forgo summer jobs and participate in this life-changing educational experience. (3) Encourage careers in science and lifelong scientific literacy. Each participant will join a sponsoring scientist's team and will design and conduct an independent, hypothesis-driven project using advanced analytic methods and tools and the outstanding scientific resources available at JAX-GM. The cancer research fellowship program will require students to attend workshops on the ethical, legal, and social issues facing scientists today and complete pre-fellowship online prequels on cancer genomics. (4) Incorporate evaluation to strengthen the program. JAX Genomic Education staff will collect formative and summative evaluation data that will directly inform program leadership to guide future administration of the program. The JAX institutional commitment ensures student access to intellectual and research resources including on-campus courses and conferences, state-of-the-art instrumentation and computational resources, dedicated program direction by JAX Genomic Education staff, housing in a college setting, and a professionally staffed residential program. The SSP––supported by institutional funds, private foundations, and federal grants––has well-established administrative procedures for recruitment and selection, mentor training, guidance, program design, management, and evaluation. JAX-GM offers a stimulating environment in which motivated, talented students from diverse backgrounds can learn the fundamentals of scientific inquiry, contribute to real research progress, and make great strides in intellectual and personal growth that will guide them in career choices and lifelong learning.

项目总结/摘要 该计划的长期目标是建立一个夏季本科生研究奖学金， 杰克逊基因组医学实验室（JAX-GM）的人类癌症分子生物学和基因组学 在法明顿，CT，这将支持需要加强教育，在癌症研究和基因组学的， 未来的生物医学劳动力这个提议的程序将作为现有JAX中的一个定义队列运行 暑期学生计划（SSP）。杰克逊实验室是一个国家癌症研究所指定的癌症中心，JAX-GM 为具有不同癌症专业知识的科学家提供了一个合作的，高度创新的研究环境， 将支持该计划的以下目标：（1）提供真实和指导的研究经验。 JAX-GM将招募10名学生加入一个尖端的合作研究团队， 计算方法研究人类乳腺、卵巢、骨骼和大脑的病因学和进化 癌症、白血病、癌症免疫疗法以及基因组结构变异和不稳定性。(2)促进 科学的多样性。参与者将通过竞争性的全国性申请程序进行选择， 将通过有针对性的国家外联活动，积极征聘任职人数不足群体的成员。每个实习生 将获得全额奖学金，包括生活费、往返交通费、研究用品和资金， 抵消住房成本。这些资金将使经济困难的学生放弃暑期工作 并参与到这个改变人生的教育体验中来。(3)鼓励科学和终身职业 科学素养每个参与者将加入一个赞助科学家的团队，并将设计和进行一个 独立的，假设驱动的项目，使用先进的分析方法和工具，以及杰出的科学 JAX-GM上可用的资源。癌症研究奖学金计划将要求学生参加 关于当今科学家面临的伦理、法律的和社会问题的研讨会，并在线完成预奖学金 癌症基因组学的前传(4)纳入评估以加强方案。JAX基因组学 教育工作人员将收集形成性和总结性评估数据，这些数据将直接告知项目领导层 以指导该计划的未来管理。JAX机构承诺确保学生获得 智力和研究资源，包括校内课程和会议，最先进的 仪器和计算资源，JAX基因组教育工作人员的专用程序方向， 在大学环境中的住房，以及专业人员的住宅计划。SSP-由 机构基金、私人基金会和联邦赠款-有完善的行政程序， 招聘和选拔、导师培训、指导、项目设计、管理和评估。JAX-GM 提供了一个激励的环境，来自不同背景的积极，有才华的学生可以学习 科学探究的基本原理，有助于真实的研究进展，并在智力和 个人成长，将指导他们的职业选择和终身学习。

项目成果

Harnessing large language models (LLMs) for candidate gene prioritization and selection.

• DOI: 10.1186/s12967-023-04576-8
• 发表时间: 2023-10-16
• 期刊: Journal of translational medicine
• 影响因子: 7.4
• 作者: Toufiq M;Rinchai D;Bettacchioli E;Kabeer BSA;Khan T;Subba B;White O;Yurieva M;George J;Jourde-Chiche N;Chiche L;Palucka K;Chaussabel D
• 通讯作者: Chaussabel D