Neurology Research Education and Mentorship Program

内科科学家越来越需要将基础神经科学的发展转化为 改善临床护理。然而，获得基础、临床和转化性研究的资金 对临床医生和研究人员来说变得越来越困难。临床神经科学实习生需要保护 在他们职业生涯的形成阶段进行研究和指导，以成功竞争被指导 职业(K)奖励和其他补助金。哥伦比亚大学神经科一直是一个强大的 支持将研究纳入住院医师的培训经验。从1979年开始， 该部门有一个T32临床神经科学培训计划，为PGY4住院医生提供资金 和一年级研究员学习研究方法。自2002年以来，一个常驻研究导师计划 已经将住院医生与教师导师配对进行研究，自2011年以来，需要一个学术项目 对所有居民来说。从2010年3月开始，R25研究导师计划提供了 供11名住院医生(9名神经科医生、1名神经外科医生、1名神经病理学家)参加指导研究 项目(平均每年1.4名住院医生)；另有3名住院医生(1名神经科医生，2名神经病理学家)申请 2018年10月购买补充剂。五名住院医生已经完成了R25体验，包括团契。的 这5人都仍在参与研究，4人获得了进一步的资助；3人(60%)申请了K奖， 两个(40%)获得了独立的K奖(一个K08，一个K23)；第三个获得了KL2奖和 2018年11月重新提交了他的K08。在仍在该计划中的五名学员中，有四名计划提交K奖 在未来1-2年内提出建议。本提案描述了一项继续这一正式居民的计划 每年至少有一名住院医师(神经内科、神经病理学或神经外科)的研究经验 被认为有成为独立研究人员的特殊前景。重点将放在一个 实践、导师指导的研究经验，课堂时间有限，参与的住院医生将 继续处于最佳位置，以便在完成培训后竞争指导职业(K)奖。Dr。 项目主任/PI，哥伦比亚大学神经学和流行病学终身教授埃尔金德说， 有独立的NIH临床研究资金，有指导住院医生和研究员的丰富经验 (包括指导神经流行病学的NINDS T32)，以及审查拨款的经验。最新的 联合调查员兼联合主任詹姆斯·戈德曼博士是一位经验丰富的神经病理学家和NIH- 资助实验室科学家，有丰富的指导经验。该项目的47名教职员工是 所有有经验的研究人员都有指导记录。该计划将继续接受评估 主要是通过学员成功获得K奖项，以及通过学术职业安置和 出版业的生产力。

There is a growing need for physician-scientists to translate developments in basic neuroscience into improvement in clinical care. Obtaining funding for basic, clinical, and translational research, however, has become increasingly difficult for clinician-investigators. Clinical neuroscience trainees require protected research time and mentoring during formative stages of their careers to compete successfully for mentored career (K) awards and other grants. The Columbia University Neurology Department has been a strong proponent of incorporating research into the training experience of residents. Beginning in 1979, the department had a T32 Clinical Neuroscience Training Program, which provided funding for PGY4 residents and first year fellows to learn research methodology. Since 2002, a Resident Research Mentorship Program has paired residents with faculty mentors to work on research, and since 2011 a scholarly project is required for all residents. Beginning in March 2010, this R25 research mentorship program has provided opportunities for 11 residents (9 neurologists, one neurosurgeon, one neuropathologist) to participate in mentored research projects (~mean 1.4 residents per year); another three residents (1 neurologist, 2 neuropathologists) applied for supplements in October 2018. Five residents have completed the R25 experience, including fellowship. Of these 5, all remain involved in research and 4 obtained further funding; three (60%) have applied for K awards, and two (40%) have obtained independent K awards (one K08, one K23); the third obtained a KL2 award and resubmitted his K08 in November 2018. Of the five trainees still in the program, four plan to submit K award proposals within the next 1-2 years. The present proposal describes a plan to continue this formalized resident research experience for at least one resident (Neurology, Neuropathology, or Neurosurgery) annually who is considered to have exceptional promise to become an independent researcher. The focus will be on a practical, mentor-directed research experience, with limited classroom time, and participating residents will continue to be optimally situated to compete for mentored career (K) awards at completion of training. Dr. Elkind, the Program Director/PI, a tenured Professor of Neurology and Epidemiology at Columbia University, has independent NIH funding for clinical research, extensive experience mentoring residents and fellows (including directing an NINDS T32 in Neuroepidemiology), and experience reviewing grants. The newly introduced co-Investigator and co-Director, Dr. James Goldman, is an experienced neuropathologist and NIH- funded laboratory scientist with extensive mentoring experience. The 47 faculty members of the program are all experienced researchers with track records of mentoring. The program will continue to be evaluated primarily by the trainees' success in obtaining K awards, as well as by academic career placement and productivity in publications.