Chronic GVHD and Management of its Sequelae

项目摘要 我们建议组织和开展第十届（第10届）年度儿科移植和细胞治疗 财团（PTCTC）会议于2023年5月9日在德克萨斯州沃斯堡的沃斯堡会议中心举行。一个独特 年度PTCTC教育会议的一个方面是，它是与国际美国协会联合举行的 的儿科血液肿瘤学会议（2023年5月10日至13日），并包括一个联合全体会议， 汇集了来自世界各地的儿科血液肿瘤学专业人士。异基因造血 细胞移植（HCT）是一种治疗儿童血液病的潜在疗法。进展 基础、转化和临床研究显著增加了长期存活者的数量。的 显著的成功部分归功于年度会议上新知识的介绍、传播和分享。 会议.然而，没有一个是专门用于儿科HCT的。该领域的一个重要问题是慢性移植- 抗宿主病（cGVHD）。尽管治愈，cGVHD是晚期发病率和死亡率的主要原因。与 他们的预期寿命更长，迫切需要了解病因，预防，发展， 诊断，并系统地评估和监测儿童cGVHD。第十届PTCTC教育年会 会议将召集临床医生和科学家，他们将介绍导致 cGVHD的发生和发展。这将提供一个平台，刺激如何实施系统的 在忙碌的临床环境中进行cGVHD评估。在这样做时，可以开发创新的临床策略， 通过多中心合作和网络进行测试，包括针对儿科特异性cGVHD的新疗法 临床试验这个为期1天的计划将振兴儿科HCT领域。主要目标包括：（一） 确定最佳供体选择策略，这些策略可以标准化并实施，无论治疗如何， II）系统地进行全面cGVHD评估，准确地将个体分类 基线和随访时的器官和总体器官严重程度，不考虑评估者; III）审查"状态“ cGVHD免疫学和受影响器官功能障碍的管理（例如，肺，眼， 阴道）; IV）增强对健康的理解，从而最大限度地提高长期生活质量， 儿童HCT患者的生存率;以及V）促进研究和临床的网络和合作24 涉及儿童HCT患者的试验。第10届PTCTC年度教育会议的结果可能会 提高我们对儿科科学研究的基础，转化和临床状态的理解- 具体的cGVHD，这将提供一个机会和平台，让年轻和高级临床医生， 科学家开展合作研究。组委会将尽一切努力， 通过增加来自不同背景的个人，包括来自代表性不足群体的个人，实现多样性。 通过旅行奖励特别鼓励受训人员和代表人数不足的少数群体参加。

PROJECT SUMMARY We propose to organize and conduct the Tenth (10th) Annual Pediatric Transplant and Cellular Therapy Consortium (PTCTC) Meeting at the Fort Worth Convention Center in Fort Worth, TX, on May 09, 2023. A unique aspect of the Annual PTCTC Educational Meeting is that it is jointly held with the international American Society of Pediatric Hematology Oncology Conference (May 10–13, 2023) and includes a Combined Plenary Session, bringing pediatric hematology oncology professionals together from around the world. Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for childhood hematological conditions. Advances in basic, translational, and clinical research have significantly increased the number of long-term survivors. The remarkable success is owed in part to the presentation, dissemination, and sharing of new knowledge at annual meetings. However, none is solely dedicated to pediatric HCT. A significant problem in the field is chronic graft- versus-host disease (cGVHD). Despite cure, cGVHD is the leading cause of late morbidity and mortality. With their longer life expectancy, a critical need exists to understand the etiology, prevention, development, and diagnosis, and systematically evaluate and monitor cGVHD in children. The 10th Annual PTCTC Educational Meeting will convene clinicians and scientists who will present on the immunologic mechanisms leading to the initiation and development of cGVHD. This will provide a platform that stimulates how to implement systematic cGVHD assessments in a busy clinical setting. In doing so, innovative clinical strategies can be developed and tested across multi-site collaborations and networks, including novel therapeutics for pediatric-specific cGVHD clinical trials. This 1-day program will invigorate the field of pediatric HCT. The primary objectives include I) identify optimal donor selection strategies that can be standardized and implemented irrespective of the treating institution; II) systematically conduct comprehensive cGVHD assessments that accurately classify individual organ and global organ severity at baseline and in follow-up irrespective of the evaluator; III) to review the ‘state of the science’ in cGVHD immunology and management of affected organ dysfunctions (e.g., pulmonary, ocular, vaginal); IV) to enhance the understanding of wellness, thereby maximizing long-term quality-of-life and survivorship of pediatric HCT patients; and V) to promote networking and collaboration of research and clinical24 trials involving pediatric HCT patients. The results of the 10th Annual PTCTC Educational Meeting will likely enhance our understanding of the basic, translational, and clinical state of the scientific research in pediatric- specific cGVHD, which will provide an opportunity and platform to engage young and senior clinicians and scientists to develop collaborative research. The Organizing Committee will make every effort to enhance diversity by increasing individuals from diverse backgrounds, including those from underrepresented groups. Participation of trainees and underrepresented minorities is especially encouraged through travel awards.