OSUCCC CUSP2CT

OSUCCC CUSP2CT

• 批准号: 10701884
• 负责人: CHERYL T. LEE
• 金额: $ 69.46万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701884
• 关键词: Address; African American; Agreement; Area; Black race; Breast; Cancer Center; Cancer Patient; Cancer health equity; Catchment Area; Centers for Population Health; Chest; Clinic; Clinical Cancer Center; Clinical Trials; Communities; Community Clinical Oncology Program; Community Health Aides; Community Hospitals; Community Outreach; Community Practice; Comprehensive Cancer Center; County; Detection; Disease; Disparity; Education; Eligibility Determination; Enrollment; Ethnic Population; Fostering; Genitourinary system; Goals; Health system; Healthcare Systems; Hematology; Hispanic; Hospitals; Institution; Intervention; Intervention Trial; Left; Malignant Neoplasms; Methods; Minority; Modality; Modeling; National Clinical Trials Network; Ohio; Outcome; Patients; Pattern; Persons; Phase; Population; Population Group; Prevention trial; Process; Provider; Public Health; Research; Resources; Risk; Site; System; Theoretical model; Therapeutic Intervention; Underrepresented Populations; Universities; Work; bilingualism; biomedical referral center; black patient; cancer health disparity; cancer prevention; cancer referral center; clinical practice; clinical trial protocol; community partnership; control trial; design; disparity gap; ethnic minority; experience; gastrointestinal; health disparity; improved; member; minority communities; outreach; participant enrollment; patient navigator; primary outcome; programs; racial minority; racial minority population; racial population; secondary outcome; success; treatment trial

PROJECT SUMMARY The overall goal of The Ohio State University (OSU) Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) is to increase the referral and accrual of racial/ethnic minorities to NCI's National Clinical Trials Network (NCTN) prevention/control and treatment trials at the OSU Comprehensive Cancer Center (OSUCCC). This research is grounded in the socioecologic model developed by the Centers for Population Health and Health Disparities (Warnecke, et al. Am J Public Health 2008) and utilizes the theoretical model, Accrual to Clinical Trials (Paskett, et al. Clin Adv Hematol Oncol 2003). The OSUCCC serves the catchment area of the state of Ohio where over 95% of our patients with cancer reside. Working closely with the OSUCCC Center for Cancer Health Equity (CCHE), OSUCCC National Outreach Network, community partner organizations, community providers in the OSUCCC referral area, James Hospital Network sites, NCI Community Oncology Research Program (NCORP) sites in Ohio, and the OSUCCC Clinical Trials Office, our goal will be accomplished by completing the following specific aims: 1) Conduct a baseline assessment of referral patterns and accrual of racial and ethnic minorities to clinical trials at OSUCCC by cancer disease group (breast, gastrointestinal, genitourinary, thoracic, hematologic, and others) and examine factors at the system (i.e., eligible clinical trial protocol, clinic context and culture), provider (trial discussed with patient), and patient level (agreed or refused participation) that influence referral and accrual (Phase I); 2) Implement a multi-level intervention in a stepped wedge design in referring practices in 9 counties with high counts of minority cancer cases in the OSUCCC catchment area using the Accrual to Clinical Trials framework (Paskett, et al. Clin Adv Hematol Oncol 2003), in Phase II. The intervention will include an outreach component, directed at community members and community practices, and an in-reach component, involving patients, providers, and the hospital system (at both referral centers and the OSUCCC) that directly addresses problems identified in Phase I; and 3) to evaluate the impact of the intervention on referral (primary outcome) and accrual patterns (secondary outcomes) in Phase III to clinical trials. Both qualitative and quantitative methods will be used. Dissemination of the key findings of our multi-level intervention is a high priority of this project.

项目摘要 俄亥俄州州立大学（OSU）的总体目标是将代表性不足的人群与临床试验联系起来 （CIP 2CT）是为了增加少数种族/民族的转诊和增加NCI的国家临床试验 网络（NCTN）预防/控制和治疗试验在OSU综合癌症中心（OSUCCC）。 这项研究是建立在人口健康和卫生中心开发的社会生态学模型基础上的 差异（Warnecke等人，Am J Public Health 2008），并利用理论模型， 试验（Paskett等人，Clin Adv Hematol Oncol 2003）。OSUCCC服务于该州的集水区， 俄亥俄州有超过95%的癌症患者。与OSUCCC癌症中心密切合作 健康公平（CCHE），OSUCCC国家外展网络，社区伙伴组织，社区 OSUCCC转诊区域的提供者、詹姆斯医院网络站点、NCI社区肿瘤学研究 计划（NCORP）在俄亥俄州的研究中心，和OSUCCC临床试验办公室，我们的目标将通过 完成以下具体目标：1）对转诊模式和应计 根据癌症疾病组（乳腺癌，胃肠道， 泌尿生殖系统、胸部、血液系统和其他）并检查系统中的因素（即，合格临床试验 方案、临床背景和文化）、提供者（与患者讨论试验）和患者水平（同意或拒绝 参与），影响转诊和累积（第一阶段）; 2）实施多层次的干预，在一个阶梯 在OSUCCC中少数民族癌症病例数高的9个县的转诊实践中采用楔形设计 使用临床试验应计框架的集水区（Paskett等人，Clin Adv Hematol Oncol 2003）， 第二阶段。干预措施将包括针对社区成员和社区的外联部分。 实践，以及涉及患者，提供者和医院系统（无论是转诊 中心和OSUCCC）直接解决第一阶段确定的问题; 3）评估影响 III期的转诊（主要结局）和累积模式（次要结局）干预， 临床试验将使用定性和定量方法。传播我们的主要调查结果 多层次干预是该项目的高度优先事项。