Neonatal Research Network: the Lurie Children's - Northwestern University Study Center

新生儿研究网络：卢里儿童 - 西北大学研究中心

• 批准号: 10682322
• 负责人: AARON HAMVAS
• 金额: $ 33.12万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682322
• 关键词: Address; Admission activity; Advocacy; Basic Science; Beds; Biological Factors; Birth; Chicago; Child; Child health equity; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Complex; Data; Data Coordinating Center; Development; Discipline of obstetrics; Disease; Disparity; Early Diagnosis; Education; Environmental Exposure; Equity; Ethnic Origin; Genetic; Geography; Goals; Growth; Health; Hospitals; Infant; Infant Mortality; Institution; Intervention; Investigation; Knowledge; Lead; Maternal Mortality; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Metabolic; Minority Groups; Mothers; Multi-Institutional Clinical Trial; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neighborhoods; Neonatal; Neonatology; Newborn Infant; Obesity; Observational Study; Outcome; Overweight; Participant; Patient Recruitments; Pediatric Hospitals; Perinatal; Physicians; Population Heterogeneity; Positioning Attribute; Pregnancy Outcome; Pregnant Women; Premature Birth; Procedures; Process; Protocols documentation; Provider; Race; Records; Reduce health disparities; Refractory; Research; Research Infrastructure; Research Institute; Research Personnel; Research Support; Resources; Scientist; Site; Therapeutic; Training; United States; Universities; Woman; adverse maternal outcomes; clinical care; clinical center; fetal programming; follow-up; health equity; health equity promotion; high risk; improved; in utero; infancy; infant outcome; maternal stress; medical schools; medically underserved; member; mother nutrition; neonatal outcome; next generation; novel; nutrition; organizational structure; outcome disparities; participant retention; pediatric department; postnatal; premature; prenatal; recruit; retention rate; service delivery; social factors; success

PROJECT SUMMARY Improving neonatal outcomes and addressing outcome disparities for mothers and their infants require national centers with excellence in clinical care and research that partner with communities to address these challenges equitably. The existence of these disparities based on race and ethnicity, specifically in maternal and infant mortality and preterm birth, highlight the complex prenatal and postnatal social and biological factors that influence pregnancy outcomes. The NICHD Neonatal Research Network (NRN), by creating a geographically diverse multi-institutional research infrastructure, has an ongoing commitment to improving health outcomes and reducing known disparities in infants born preterm and in other high-risk situations. The Lurie Children’s - Northwestern University Study Center, comprised of the Division of Neonatology at the Ann & Robert H. Lurie Children’s Hospital of Chicago and the Department of Pediatrics at Northwestern University Feinberg School of Medicine, is anchored by 12,000 deliveries per year and 1700 admissions per year to our 148 NICU beds at Lurie Children’s Hospital and Prentice Women’s Hospital and our collaboration with our partners at the Northwestern Maternal-Fetal Medicine Units (MFMU) Study Center. We have a long-standing tradition of clinical excellence, investigator-initiated and multi-center investigation, a commitment to train the next generation of physician scientists, and advocacy to promote health equity. Thus, we are well-positioned to be a strong addition as a Clinical Center to the NRN. To achieve the goals of the NRN, the Lurie Children’s-Northwestern Study Center will: 1) capitalize on the existing synergistic relationships within the Lurie Children’s / Northwestern Medical Center and underserved neighborhoods of Chicago to “facilitate greater involvement of diverse populations” and promote recruitment of pregnant women and their newborns for study protocols and facilitate their retention through the follow-up period; 2) propose and participate in novel clinical studies and analyses that capitalize on unique resources at the Lurie Children’s-Northwestern site; 3) utilize our site’s effective organizational structure and management approach to support the objectives of the NRN; 4) establish and implement high-quality data and biospecimen collection processes that meet the requirements and standards of the NRN based on our current success with these processes; and 5) contribute to the scientific collaboration among the NICHD, the NRN and MFMU clinical centers, and the Data Coordinating Center to support the research networks’ objectives.

项目摘要 改善新生儿结局和解决母婴结局差异需要 在临床护理和研究方面具有卓越成就的国家中心，与社区合作， 公平地应对这些挑战。这些基于种族和族裔的差异的存在，特别是在 母婴死亡率和早产率，凸显出产前产后复杂的社会和生物 影响怀孕结果的因素。NICHD新生儿研究网络（NRN）通过创建一个 地理上多样化的多机构研究基础设施，不断致力于改善健康 这将有助于改善早产儿和其他高风险情况下出生的婴儿的结局，并减少早产儿和其他高风险情况下出生的婴儿的已知差异。卢瑞 儿童-西北大学研究中心，由Ann & Robert新生儿科组成 H.芝加哥Lurie儿童医院和西北大学Feinberg儿科 医学院，每年有12，000名分娩，每年有1700名新生儿重症监护室（NICU）148名新生儿重症监护室（NICU） 卢里儿童医院和普伦蒂斯妇女医院的床位，以及我们与合作伙伴在 西北母胎医学单位（MFMU）研究中心。我们有着悠久的临床传统 卓越，发起人和多中心的研究，致力于培养下一代的 医生科学家和倡导促进健康公平。因此，我们有能力成为一个强大的补充 作为NRN的临床中心。为了实现NRN的目标，Lurie儿童西北研究 中心将：1）利用Lurie儿童/西北部现有的协同关系 医疗中心和芝加哥服务不足的社区，以“促进更多的参与， 促进招募孕妇及其新生儿参与研究方案， 在随访期内保持他们; 2）提出并参与新的临床研究和分析， 利用卢里儿童西北网站的独特资源; 3）利用我们网站的有效 支持国家重建网络目标的组织结构和管理方法; 4）建立和 实施高质量的数据和生物样本采集流程，以满足以下要求和标准： NRN基于我们目前在这些过程中取得的成功; 5）促进科学合作 在NICHD、NRN和MFMU临床中心以及数据协调中心之间， 研究网络的目标。