Childrens' of Mississippi Neonatal Research Group

密西西比儿童新生儿研究小组

• 批准号: 10682988
• 负责人: Abhay J Bhatt
• 金额: $ 29.64万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682988
• 关键词: Address; Admission activity; Agreement; American College of Obstetricians and Gynecologists; Behavior Disorders; Cardiorenal syndrome; Caring; Centers of Research Excellence; Child; Child Welfare; Childhood; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Network; Collaborations; Compassion; Conduct Clinical Trials; Dedications; Development; Eligibility Determination; Enrollment; Ethics; Ethnic Origin; Faculty; Funding; Future; Goals; Health; Health Personnel; Healthcare; Hour; Industry; Infant; Information Systems; Infrastructure; Institution; Intervention Studies; Intravenous; Life; Link; Low Birth Weight Infant; Medical center; Medicine; Metabolic Diseases; Mission; Mississippi; Multi-Institutional Clinical Trial; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Newborn Infant; Obesity; Observational Study; Outcome; Participant; Patient Care; Perinatal; Population; Positioning Attribute; Pre-Eclampsia; Pregnancy; Premature Birth; Recording of previous events; Reproducibility; Research; Research Infrastructure; Research Personnel; Services; Site; Study Subject; System; Training; Translational Research; Translations; Treprostinil; Underserved Population; United States National Institutes of Health; Universities; Vision; Work; arm; autism spectrum disorder; base; bench to bedside; clinical center; clinical research site; community intervention; disparity reduction; economic disparity; eligible participant; ethnic minority; experience; fetal; follow-up; health care disparity; health disparity; high risk; high risk population; improved; innovation; low socioeconomic status; maternal hypertension; mid-career faculty; multidisciplinary; neonatal health; neonatal pulmonary hypertension; next generation; programs; public health insurance; racial diversity; racial minority; recruit; rural area; success; urban area

This application strongly supports the Mississippi state's only academic Level IV newborn facility, the Children's of Mississippi Newborn Intensive Care Unit (NICU) at the University of Mississippi Medical Center (UMMC)'s candidacy as a clinical center by the NICHD Neonatal Research Network (NRN). We work to improve the life of Mississippi children by providing exceptional patient care, training the next generation of healthcare providers, and engaging in innovative research to achieve the vision of UMMC to improve Mississippian's health outcomes and eliminate health care disparities. Researchers in the newborn division are contributing by performing innovative, definitive, rigorous, and reproducible translation, single and multi-site clinical, and community interventions research focused on improving newborn health to reduce the gap between “bench to bedside to countryside” research. The newborn center at the UMMC is exceptionally well positioned to be selected for the following reasons. 1) We serve a very high-risk and underserved population, the majority with low socioeconomic status and public insurance from urban and rural areas with high representation of racial/ethnic minorities facing health disparities. 2) Mississippi has some of the highest rates of maternal hypertension, preeclampsia, obesity, metabolic disorders, preterm birth, low birth weight, and congenitally linked behavioral disorders, such as autism in the USA. 3) The Center for Maternal and Fetal Care at UMMC, the only quaternary center for advanced fetal care in the state, manages around 3,000 deliveries each year, of which 75% are considered high risk. 4) About 1000 NICU admissions per year, of which almost 160 are born less than 29 weeks of gestation, and about 70% are inborn. 5) The Division of Newborn Medicine has a well-organized clinical research infrastructure with a successful track record of participation in multi-center NIH, industry-sponsored, and investigator-initiated clinical trials in newborns. 6) The Division has consistently been the highest study subject recruiting site in many multi-center clinical trials. This success is attributable to the strong research culture and a unique system of round-the-clock availability of dedicated research coordinators, including after- hours and weekends. This is an exceptional strength of our program. 7) The institution maintains a long- standing multidisciplinary Newborn Follow-up Program that serves the entire state. 8) The Division of Newborn Medicine has consistently received Institutional support. It has a long-standing history of collaboration with other institutional centers/departments with NIH-funded programs. If selected, we will be fully committed to participating in all Network studies unless they do not have the relevant eligible population. We agree to prioritize Network studies over other studies, including other NIH- funded studies, for subject recruitment at our center.

该应用程序强烈支持密西西比州唯一的学术级别IV新生儿设施， 密西西比州密西西比州密西西比州医学中心的密西西比州新生儿重症监护病房（NICU） （UMMC）由NICHD新生儿研究网络（NRN）作为临床中心的候选人资格。我们努力 通过提供出色的患者护理，培训下一代，改善密西西比儿童的生活 医疗保健提供者，并从事创新研究以实现UMMC的愿景以改善 密西西比州的健康成果并消除了医疗保健分配。新生儿的研究人员是 通过执行创新，确定，严格和可重复的翻译，单位和多站点来做出贡献 临床和社区干预研究的重点是改善新生儿健康以减少差距 长凳到乡村研究。 UMMC的新生儿中心出于以下原因而被选择得很好。 1） 我们为高风险和服务不足的人口服务，大多数社会经济地位和公众人数低 来自城市和艰难地区的保险，对健康/少数民族的较高代表面对健康 差异。 2）密西西比州的母亲高血压，先兆子痫，肥胖症，肥胖症的率最高 代谢障碍，早产，低出生体重和先天性联系的行为障碍，例如 在美国的自闭症。 3）UMC的母亲和胎儿护理中心，UMC是唯一的第四纪中心 该州的高级胎儿护理，每年管理约3,000次交货，其中75％被考虑 高风险。 4）每年大约有1000名NICU入院，其中近160个出生不到29周 妊娠，约70％是天生的。 5）新生儿的分裂有组织良好的临床 研究基础架构具有成功参与多中心NIH的成功记录，该行业赞助， 和研究人员发起的新生儿临床试验。 6）该部门一直是最高研究 在许多多中心临床试验中，受试者招募部位。这种成功归因于强大的研究 文化和专门研究协调员的全天候可用性的独特系统，包括后 小时和周末。这是我们计划的特殊优势。 7）该机构维持一个长期 为整个州提供服务的跨学科新生儿随访计划。 8）新生儿的师 医学一直在获得机构支持。它有与之合作的悠久历史 其他机构中心/部门拥有由NIH资助的计划。 如果选择了，除非他们没有 相关的合格人口。我们同意将网络研究优先于其他研究，包括其他NIH- 资助的研究，用于我们中心的受试者招募。