A Novel N-of-1 Randomized, Controlled, Clinical Trial to Assess the Effect of Blenderized Tube Feeds on Esophagogastric Physiology
一项新颖的 N-of-1 随机对照临床试验,用于评估混合管饲对食管胃生理学的影响
基本信息
- 批准号:10682492
- 负责人:
- 金额:$ 19.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdmission activityAdoptedAdultAdvisory CommitteesAffectAspiration PneumoniaBerryBiometryBolus InfusionBostonChildChild health careChildhoodChronic DiseaseClassificationClinicalClinical ManagementClinical ResearchClinical TrialsCoughingCoupledCross-Over StudiesDataDeglutitionDependenceDevelopmentDietDietary InterventionDiseaseEnteralEnteral FeedingEnvironmentEsophagusEventExpenditureFabaceaeFeedsFoodFruitFunctional disorderFundusFutureGastric EmptyingGastroenterologistGastroesophageal reflux diseaseGastroparesisGastrostomyGoalsHealthHealth Care CostsHealth ExpendituresHeterogeneityHospitalizationIllinoisImpairmentIndividualInfantInferior esophageal sphincter structureInflammationIngestionInstructionInvestigationK-Series Research Career ProgramsLiteratureLocationLungMacronutrients NutritionMaster of ScienceMeasuresMeatMediatorMedicalMedical TechnologyMedicineMentorsMentorshipMetabolismMethodologyMethodsMicronutrientsNausea and VomitingNeurologicNutritionalObservational StudyOutcomeParentsParticipantPatientsPediatric HospitalsPhysiciansPhysiologicalPhysiologyPopulationPublic Health SchoolsQuality of lifeQuestionnairesRadionuclide ImagingRandomizedRandomized Controlled Clinical TrialsRandomized, Controlled TrialsRefluxRegulationResearchResearch ActivityResearch DesignResearch PersonnelScholarshipSecondary toSpecialistStatistical Data InterpretationStomachSymptomsSystemTechniquesTestingTimeTrainingTraining ActivityTubeUniversitiesVegetablesViscosityVulnerable PopulationsWorkburden of illnesscareercatalystcell motilitychemical propertyclinical carecourse developmentdesigndiariesevidence baseexperiencefeedingfood sciencegastrointestinalgastrointestinal symptomhealth care service utilizationimprovedindexinginnovationintervention effectmedical schoolsnovelnovel markernutritionphysical propertypreservationprimary outcomeprogramsprospectivepulmonary symptomreduce symptomsresponsesecondary outcomestatistical learningstroke victimssymptomatic improvementsymptomatologytrial comparingtrial design
项目摘要
PROJECT SUMMARY
The fragile population of children with medical complexity (children with congenital or acquired multisystem
disease, neurologic impairment and/or dependence on medical technology) accounts for up to one third of all
pediatric medical expenditure. Systematic investigation of the contribution of nutrition to chronic disease burden
in this population has not been done and is urgently needed, as it has vast potential to optimize clinical outcomes
such as feeding intolerance, improve quality of life and reduce healthcare cost. Dr. Bridget Hron is a pediatric
gastroenterologist and nutrition specialist with advanced training in the nutritional regulation of metabolism and
inflammation who is perfectly suited to address this critical unmet need. Her career goal is to direct a clinical
research program focused on discovering evidenced-based, state of the art nutritional interventions that
transform the clinical care of the most vulnerable pediatric population.
In Dr. Hron's recent work, she has shown that blenderized diets, which are pureed high quality table foods such
as fruits, vegetables, meat and legumes administered via gastrostomy tube have a beneficial effect on health
care utilization, reducing admissions for pulmonary reasons by 53%. Over the course of this career development
award, Dr. Hron will study the effect of blenderized feeds varying in viscosity on gastrointestinal symptoms and
on esophageal and gastric function. The innovative aggregate randomized, controlled N-of-1 study design
outlined in this proposal allows each individual participant to determine diet of maximal efficacy, but also allows
for estimation of population effect of the interventions.
The exceptional mentorship and original scientific training proposed in this career development award are critical
for Dr. Hron's academic development. Dr. Rachel Rosen, primary mentor, is an expert in aerodigestive medicine,
and Dr. Christopher Schmid, co-mentor, is an expert in biostatistics with a focus on N-of-1 trials – both have
outstanding backgrounds in clinical research with deep commitment to mentorship. She will be supported by her
Scholarship Advisory Committee consisting of Drs. Wayne Lencer, Christopher Duggan, Jay Berry and Sharon
Donovan, who lend content-area expertise. Her formal training will include a Master of Science: Concentration
in Food Science at University of Illinois Urbana-Champaign, advanced courses in statistical analysis at the
Harvard T.H. Chan School of Public Health (HSPH), personal instruction on mediators of esophageal and gastric
motility by Dr. Rosen, and professional development courses through HSPH and Harvard Catalyst. Her training
and research activities will be conducted in the unparalleled academic environments of Boston Children's
Hospital and Harvard Medical School, which are firmly committed to Dr. Hron's successful transition to an
independent research career.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bridget Mary Hron其他文献
Bridget Mary Hron的其他文献
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{{ truncateString('Bridget Mary Hron', 18)}}的其他基金
A Novel N-of-1 Randomized, Controlled, Clinical Trial to Assess the Effect of Blenderized Tube Feeds on Esophagogastric Physiology
一项新颖的 N-of-1 随机对照临床试验,用于评估混合管饲对食管胃生理学的影响
- 批准号:
10507301 - 财政年份:2022
- 资助金额:
$ 19.28万 - 项目类别:
Effects of Anti-Inflammatory Diet on Pulmonary Function in Pediatric Asthma
抗炎饮食对小儿哮喘肺功能的影响
- 批准号:
8649736 - 财政年份:2014
- 资助金额:
$ 19.28万 - 项目类别: