Maternal Fetal Medicine Units Network - Northwestern Study Center

项目总结 在美国，每年有近400万新生儿出生，分娩是导致 住院治疗。因此，预防早产和孕产妇发病率在临床上具有重要意义。 和公共卫生目标。此外，产妇和新生儿的不良结局是主要健康的来源。 美国的不平等现象；产科护理、治疗干预和筛查或诊断方面的改进 战略有可能改善所有个人的结果，特别是那些来自不同国家的人 人口。为了实现这些目标，需要创新和变革性的产科研究，使 严谨的多点临床试验和观察性研究，旨在最大限度地改善产科结局 重要性。 母婴医学单位(MFMU)网络，通过创建多站点研究基础设施，是一种 有效实现这一目标的重要机制。西北研究中心，通过使用它的 创新的招聘和学习设计，强大的科学领导力，杰出的学术成就 生产力，以及可用于研究的大量和多样化的患者群体，一直是富有成效的 自2001年起成为MFMU网络成员。西北研究中心由两个机构组成-- 西北大学和北岸大学医疗系统-这两所大学已经有20年的成功历史 合作，包括在MFMU网络内。分娩个体的总接生量 在这些地点的护理是19,000个出生；这些出生的大量发生在来自 多样化、代表性不足的人群或面临不良后果的高风险。 在本申请中，我们建议西北研究中心继续参加NICHD MFMU 网络。经验丰富的临床研究人员团队(Lynn Yee，医学博士，公共卫生硕士；Michelle Kominiarek，医学博士，医学硕士；Beth Plunkett，医学博士，公共卫生硕士；Gail Mallett，RN)，他们在产科方面拥有长期的和全国公认的专业知识 一般的临床研究和MFMU网络具体来说，领导这一更新应用。带着强大的 机构支持，独特的协作研究环境，以及之前成功参与和 作为多点临床试验的领导者，西北研究中心将继续为 MFMU网络通过积极招收不同社会经济背景的个人和 完成新颖而重要的研究。

PROJECT SUMMARY In the United States (US), there are nearly 4 million births per year, and childbirth is the leading indication for hospitalization. Correspondingly, the prevention of preterm birth and maternal morbidity are important clinical and public health goals. In addition, adverse maternal and neonatal outcomes are sources of major health inequities in the US; improvements in obstetric care, therapeutic interventions, and screening or diagnostic strategies have the potential to improve outcomes for all individuals, and particularly those from diverse populations. Innovative and transformational obstetric research is required to achieve these goals, making rigorous, multi-site clinical trials and observational studies designed to improve obstetric outcomes of the utmost importance. The Maternal-Fetal Medicine Units (MFMU) Network, by creating a multi-site research infrastructure, is an important mechanism to effectively accomplish this goal. The Northwestern Study Center, through its use of innovative recruitment and study designs, strong scientific leadership, outstanding academic productivity, and a large and diverse patient population available for research, has been a productive member of the MFMU Network since 2001. The Northwestern Study Center is composed of two institutions – Northwestern University and NorthShore University HealthSystem – that have a two-decade history of successful collaboration, including within the MFMU Network. The combined volume of birthing individuals receiving care at these sites is 19,000 births; a high volume of these births occur to individuals who are from diverse, underrepresented populations or at high risk for adverse outcomes. In this application, we propose that the Northwestern Study Center continues to participate in the NICHD MFMU Network. A team of experienced clinical researchers (Lynn Yee, MD, MPH; Michelle Kominiarek, MD, MS; Beth Plunkett, MD, MPH; Gail Mallett, RN), who have longstanding and nationally-recognized expertise with obstetric clinical research in general and the MFMU Network specifically, lead this renewal application. With strong institutional support, a uniquely collaborative research environment, and prior successful participation in and leadership of multi-site clinical trials, the Northwestern Study Center will continue its significant contributions to the MFMU Network’s goals through robust enrollment of socioeconomically diverse individuals and the completion of novel and important studies.