Columbia University Maternal-Fetal Medicine Units Network Clinical Center

哥伦比亚大学母胎医学单位网络临床中心

• 批准号: 10682972
• 负责人: Uma Reddy
• 金额: $ 36.19万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682972
• 关键词: Address; Asian; Awareness; Basic Science; Black race; Bylaw; Caring; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Complement; Complex; Country; Data; Data Collection; Dedications; Delaware; Discipline; Discipline of obstetrics; Enrollment; Equipment; Ethnic Origin; Genomics; Goals; Health; Healthcare Systems; Hispanic; Hospitals; Human Resources; Image; Infant; Infant Mortality; Information Dissemination; Lactation; Longitudinal Studies; Longterm Follow-up; Low Birth Weight Infant; Maternal Mortality; Maternal complication; Maternal-Fetal Medicine Units Network; Maternity Hospitals; Mentors; Morbidity - disease rate; Multi-Institutional Clinical Trial; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Neonatology; Observational Study; Obstetric pharmacology; Outcome; Participant; Pathology; Patient Care; Patients; Perinatal; Persons; Pharmaceutical Preparations; Population; Population Heterogeneity; Postpartum Period; Pregnancy; Productivity; Proteomics; Protocols documentation; Provider; Publications; Qualifying; Race; Recovery; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Safety; Saints; Services; Site; Socioeconomic Status; Specimen; Standardization; Structure; Supervision; System; Translational Research; Treatment Efficacy; United States National Institutes of Health; Universities; University Hospitals; clinical care; clinical center; clinical practice; eligible participant; evidence base; experience; health disparity; high risk; improved; infant death; infant morbidity; innovation; medication safety; multidisciplinary; neurodevelopment; next generation; obstetric care; operation; patient population; pregnant; premature; randomized trial; recruit; service delivery; skills; success; trial design; underserved community

Abstract/Project Summary The Columbia Center has a 20-year track record of excellence within the Maternal Fetal Medicine Units (MFMU) Network and collaborating in large multi-site clinical trials and longitudinal studies in pregnant and lactating people. During the last current cycle of the MFMU, the Columbia Center ranked near the top in recruitment for every study. The Columbia Center will be composed of Columbia University and 3 satellite sites including: Christiana Care Health System, Saint Peter's University Hospital, and Yale New Haven Hospital which operate under a common administrative and oversight structure. Together, these 4 large- volume delivery centers provide access to 23,500 patients annually with diversity in race and ethnicity (24% Black, 24% Hispanic, 9% Asian), socioeconomic status, and access to underserved communities. As a result of our strong presence of MFM, Neonatology and subspecialty care and facilities at each site, 40% of our overall delivery population is high-risk. Network protocols will be conducted in a coordinated, rigorous and safe manner by our Center's highly qualified investigators, staff, dedicated MFMU facilities and culture of clinical research being part of clinical care. The Columbia Center has the experience and expertise to collaboratively conduct multi-site randomized trials and large observational studies with timely recruitment, community- engaged enrollment of eligible participants from diverse patient populations with excellent retention and rigorous data collection to contribute to results which will promote advances in obstetric practice. The Columbia Center has numerous strengths and will provide multidisciplinary expertise on obstetrics, neonatology, obstetric pharmacology, infant neurodevelopment and lactation clinical practice to address maternal death and complications related to pregnancy, labor, and post-partum recovery; to reduce prematurity, low-birth weight, infant death, and infant complications and expand the evidence base about the safety and efficacy of medications used during pregnancy and lactation. Our Center has state-of-the-art scientific capabilities for Network research including imaging, genomics, proteomics, placental function assessment, innovative trial design and analyses, and specialized support of clinical trials. Lastly, our goal is to provide rigorous data and biospecimen collection to share as a resource for other investigators to advance evidence-based obstetric practice.

摘要/项目摘要 哥伦比亚中心在母胎医学部门拥有20年的卓越记录 （MFMU）网络和合作在大型多地点临床试验和纵向研究，在怀孕和 哺乳期的人在MFMU的上一个当前周期中，哥伦比亚中心在 每项研究的招募。哥伦比亚中心将由哥伦比亚大学和3颗卫星组成 地点包括：Christiana Care Health System、圣彼得大学医院和耶鲁纽黑文 在共同行政和监督结构下运作医院。这四个大- 批量交付中心每年为23，500名患者提供服务，其中种族和民族多样性（24%） 黑人，24%的西班牙裔，9%的亚洲人），社会经济地位，并获得服务不足的社区。因此 我们强大的MFM，新生儿和专科护理和设施在每个站点的存在，我们的40%， 总的分娩人口是高风险的。网络协议将以协调、严谨和安全的方式进行 我们中心的高素质的研究人员，工作人员，专门的MFMU设施和临床文化的方式 研究是临床护理的一部分。哥伦比亚中心拥有丰富的经验和专业知识， 进行多中心随机试验和大型观察性研究，及时招募，社区- 参与招募来自不同患者人群的合格参与者，保持良好， 严格收集数据，以促进取得成果，推动产科实践的进步。的 哥伦比亚中心有许多优势，并将提供产科多学科的专业知识， 产科医学，产科药理学，婴儿神经发育和哺乳临床实践，以解决 产妇死亡和与怀孕、分娩和产后恢复有关的并发症;减少 早产、低出生体重、婴儿死亡和婴儿并发症，并扩大关于 妊娠期和哺乳期使用药物的安全性和有效性。我们的中心拥有最先进的 网络研究的科学能力，包括成像、基因组学、蛋白质组学、胎盘功能 评估，创新的试验设计和分析，以及临床试验的专业支持。最后，我们的目标是 提供严格的数据和生物标本收集，作为其他研究人员推进的资源进行共享 循证产科实践。