Adenosine Receptor Context-Specific Biased Agonism to Treat Ischaemic Heart Disease

腺苷受体上下文特异性偏向激动治疗缺血性心脏病

• 批准号: nhmrc : 1147291
• 负责人: A/Pr Paul White
• 金额: $ 68.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adenosine-receptor-context-heart-disease/1320814
• 关键词: Adenosine; Receptor; Context; Specific; Biased

Heart attacks and secondary heart failure remain significant health burdens. Stimulation of adenosine receptors located on heart cells confers powerful cardiac protection, improving acute and longer-term heart function subsequent to a heart attack but avoiding the usual unwanted effects from this approach. We aim to better understand the mechanism of action of potential adenosine receptor therapeutics and establish the clinical potential of these compounds using animal models of heart failure.

心脏病发作和继发性心力衰竭仍然是重大的健康负担。刺激位于心脏细胞上的腺苷受体可以提供强大的心脏保护，改善心脏病发作后的急性和长期心脏功能，但避免了这种方法的常见不良影响。我们的目的是更好地了解潜在的腺苷受体治疗剂的作用机制，并建立这些化合物的心力衰竭动物模型的临床潜力。