BioSpectroscopy Research Laboratory

生物光谱研究实验室

• 批准号: 10684917
• 负责人: J B ALEXANDER ROSS
• 金额: $ 9.87万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684917
• 关键词: Address; Alaska; Alberta province; Applications Grants; Award; Biochemical; Biochemistry; Biological Sciences; Biophysics; Biotechnology; Canada; Cells; Centers of Research Excellence; Charge; Client; Client satisfaction; Collaborations; Communities; Complex; Data; Disease; Doctor of Philosophy; Educational process of instructing; Educational workshop; Effectiveness; Electronics; Ensure; Environmental Health; Evaluation; Fee-for-Service Plans; Fees; Fluorescence; Fluorescence Spectroscopy; Fostering; Foundations; Funding; Geoscience; Grant; Health; Image; Individual; Industrialization; Institution; Laboratory Research; Lasers; Lateral; Measures; Microscope; Microscopic; Microscopy; Mission; Molecular Biology; Monitor; Montana; Neurosciences; Outcome; Pacific Northwest; Phase; Photons; Postdoctoral Fellow; Productivity; Progress Reports; Reporting; Research; Research Personnel; Resolution; Resources; Scanning; Science; Scientist; Services; Specificity; Spectrum Analysis; Structure; Students; Surveys; System; Technology; Time; Tissues; Training; Training and Education; Trust; United States National Institutes of Health; Universities; Visualization; Washington; analytical ultracentrifugation; base; biological systems; biomacromolecule; confocal imaging; design; experience; experimental study; fluorescence imaging; fluorescence lifetime imaging; graduate student; imaging system; insight; instrumentation; interdisciplinary approach; lectures; multiphoton microscopy; operation; programs; service programs; single molecule; small molecule; success; tool; training opportunity; translational medicine; ultra high resolution

The BioSpectroscopy Core Research Laboratory (BCRL) of the Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) provides investigators with state-of-the-art imaging and spectroscopy resources for investigating research questions in fields including, but not limited to, biochemistry, biophysics, and neuroscience. The fluorescence technologies offered by the BCRL include both intensity- based and time-resolved platforms, which provide high temporal and spatial resolution for visualizing and measuring the dynamic structures and interactions of biological systems ranging in size from multicellular complexes down to single molecules. Understanding, on the macroscopic scale, the spatial/dynamic organization of interacting systems in cells and tissues, and on the microscopic scale, the dynamic structures and the strengths and specificity of interactions of, for example biomacromolecules and their small-molecule regulators, together afford critical insights into biophysical and biochemical mechanisms important in health and disease. The BCRL resources are available either as fee-for-service or on a collaborative basis. The BCRL also provides its technologies and expertise in fluorescence to research organizations and academic institutions in the Pacific Northwest, including the University of Alaska (IDeA State) at Fairbanks and the Canadian Center for Hydrodynamics at the University of Lethbridge, Alberta, Canada. The BCRL uses reporting tools to track its effectiveness in providing services for clients, evaluating scientific outcomes, and monitoring financial status. The BCRL also uses evaluation/survey tools to assess client satisfaction, ensure effective operation, identify emerging needs, and prioritize new and ongoing projects. To ensure sustainability beyond the Phase III COBRE, the BCRL will maintain a robust fee-for-service program, leverage institutional support, and pursue grant-funded collaborations with UM investigators and external users.

生物分子结构与研究中心生物光谱核心研究实验室 蒙大拿大学(UM)的动力学(CBSD)为研究人员提供最先进的成像和 用于研究包括但不限于生物化学领域的研究问题的光谱资源， 生物物理学和神经科学。BCRL提供的荧光技术包括强度- 基于时间分辨率的平台，提供高时间和空间分辨率用于可视化和 测量从多细胞到大小不等的生物系统的动态结构和相互作用 小到单分子的复合体。在宏观尺度上理解空间/动态 细胞和组织中相互作用系统的组织，以及在微观尺度上的动态结构 以及例如生物大分子及其小分子的相互作用的强度和特异性 监管机构共同提供了对健康重要的生物物理和生化机制的关键见解 和疾病。BCRL资源可以按服务收费或在协作的基础上提供。这个 BCRL还向研究机构和学术界提供其在荧光方面的技术和专业知识 太平洋西北地区的机构，包括位于费尔班克斯的阿拉斯加大学(Idea State)和 加拿大阿尔伯塔省莱斯布里奇大学的加拿大流体动力学中心。BCRL使用 报告工具，以跟踪其在为客户提供服务、评估科学成果和 监控财务状况。BCRL还使用评估/调查工具来评估客户满意度，确保 有效运作，识别新出现的需求，并确定新项目和正在进行的项目的优先顺序。确保可持续性 除了第三阶段的Cobre，BCRL将保持一个强大的按服务收费计划，利用机构 支持并寻求与UM调查人员和外部用户的赠款资助的合作。