BioSpectroscopy Research Laboratory

生物光谱研究实验室

• 批准号: 10684917
• 负责人: J B ALEXANDER ROSS
• 金额: $ 9.87万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684917
• 关键词: Address; Alaska; Alberta province; Applications Grants; Award; Biochemical; Biochemistry; Biological Sciences; Biophysics; Biotechnology; Canada; Cells; Centers of Research Excellence; Charge; Client; Client satisfaction; Collaborations; Communities; Complex; Data; Disease; Doctor of Philosophy; Educational process of instructing; Educational workshop; Effectiveness; Electronics; Ensure; Environmental Health; Evaluation; Fee-for-Service Plans; Fees; Fluorescence; Fluorescence Spectroscopy; Fostering; Foundations; Funding; Geoscience; Grant; Health; Image; Individual; Industrialization; Institution; Laboratory Research; Lasers; Lateral; Measures; Microscope; Microscopic; Microscopy; Mission; Molecular Biology; Monitor; Montana; Neurosciences; Outcome; Pacific Northwest; Phase; Photons; Postdoctoral Fellow; Productivity; Progress Reports; Reporting; Research; Research Personnel; Resolution; Resources; Scanning; Science; Scientist; Services; Specificity; Spectrum Analysis; Structure; Students; Surveys; System; Technology; Time; Tissues; Training; Training and Education; Trust; United States National Institutes of Health; Universities; Visualization; Washington; analytical ultracentrifugation; base; biological systems; biomacromolecule; confocal imaging; design; experience; experimental study; fluorescence imaging; fluorescence lifetime imaging; graduate student; imaging system; insight; instrumentation; interdisciplinary approach; lectures; multiphoton microscopy; operation; programs; service programs; single molecule; small molecule; success; tool; training opportunity; translational medicine; ultra high resolution

The BioSpectroscopy Core Research Laboratory (BCRL) of the Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) provides investigators with state-of-the-art imaging and spectroscopy resources for investigating research questions in fields including, but not limited to, biochemistry, biophysics, and neuroscience. The fluorescence technologies offered by the BCRL include both intensity- based and time-resolved platforms, which provide high temporal and spatial resolution for visualizing and measuring the dynamic structures and interactions of biological systems ranging in size from multicellular complexes down to single molecules. Understanding, on the macroscopic scale, the spatial/dynamic organization of interacting systems in cells and tissues, and on the microscopic scale, the dynamic structures and the strengths and specificity of interactions of, for example biomacromolecules and their small-molecule regulators, together afford critical insights into biophysical and biochemical mechanisms important in health and disease. The BCRL resources are available either as fee-for-service or on a collaborative basis. The BCRL also provides its technologies and expertise in fluorescence to research organizations and academic institutions in the Pacific Northwest, including the University of Alaska (IDeA State) at Fairbanks and the Canadian Center for Hydrodynamics at the University of Lethbridge, Alberta, Canada. The BCRL uses reporting tools to track its effectiveness in providing services for clients, evaluating scientific outcomes, and monitoring financial status. The BCRL also uses evaluation/survey tools to assess client satisfaction, ensure effective operation, identify emerging needs, and prioritize new and ongoing projects. To ensure sustainability beyond the Phase III COBRE, the BCRL will maintain a robust fee-for-service program, leverage institutional support, and pursue grant-funded collaborations with UM investigators and external users.

生物分子结构和生物学中心的生物光谱学核心研究实验室（BCRL） 蒙大拿大学（UM）的动态（CBSD）为研究人员提供了最先进的成像技术， 光谱学资源，用于调查包括但不限于，生物化学， 生物物理学和神经科学。BCRL提供的荧光技术包括强度- 基于和时间分辨的平台，为可视化提供高时间和空间分辨率， 测量生物系统的动态结构和相互作用， 复合物到单个分子。在宏观尺度上理解空间/动态 在细胞和组织中相互作用系统的组织，以及微观尺度上的动态结构 以及例如生物大分子及其小分子的相互作用的强度和特异性 监管机构，共同提供重要的生物物理和生物化学机制的重要见解，在健康 和疾病BCRL资源可以收费服务或协作方式提供。的 BCRL还向研究组织和学术机构提供荧光技术和专业知识。 在太平洋西北部的机构，包括阿拉斯加大学（IDEA州）在费尔班克斯和 加拿大阿尔伯塔莱斯布里奇大学的加拿大流体动力学中心。BCRL使用 用于跟踪其在为客户提供服务、评估科学成果方面的有效性的报告工具，以及 监测财务状况。BCRL还使用评估/调查工具来评估客户满意度，确保 有效运作，确定新出现的需求，并优先考虑新的和正在进行的项目。以确保可持续性 在COBRE第三阶段之后，BCRL将保持一个强有力的按服务收费的计划，利用机构资源 支持，并追求赠款资助的合作与UM调查员和外部用户。