Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies

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ABSTRACT The Cancer Research Training Program (CRTP) at the University of Virginia brings together faculty and trainees with a common interest in cancer biology to participate in an integrated program of cancer research, education, and discovery. The overall objective of the CRTP is to empower the next generation of cancer researchers with the tools to become future leaders in the quest to understand oncological processes and improve patient outcomes. We accomplish these goals through intensive cancer research training coupled with academic and professional development activities. Together, these provide the trainees with (1) a broad-based knowledge of fundamental principles in cancer biology; (2) the ability to define and solve vital research questions using the most current approaches and techniques in the constantly changing landscape of biomedical research; and (3) the skills to partner with basic scientists, translational researchers, clinical trialists, clinicians, and cancer patients/survivors to promote discovery and improved outcomes. This renewal application incorporates a new leadership structure prompted by the addition of Dr. Andrew Dudley as part of a multi-PI team with the current PI, Dr. Amy Bouton. We request support for 8 predoctoral trainees who will participate in longitudinal training that includes laboratory research, formal course work, programmatic activities, exposure to clinical/translational aspects of cancer, programming in professional/career development, and community outreach opportunities. The 42 CRTP faculty mentors provide a robust and fully integrated platform through which the program delivers this training. Most importantly, the CRTP takes advantage of the robust cancer research community provided by the NCI-designated UVA Cancer Center. This affords the trainees an opportunity to apply their own experiences in basic cancer research to the need for improved diagnosis and treatments in cancer care. The CRTP has experienced much success over its almost 44-year history. As we move into the next funding period, we challenge ourselves to meet the changing landscape of cancer research through constant assessment and evolution of the program. In this regard, we have incorporated a number of new initiatives designed to reinforce community-building, provide new opportunities for applied learning and professional development, and promote dialogues between trainees and cancer patients/survivors. This renewal application also includes important new enhancements focused on training in rigor and reproducibility, mentor training, and the establishment of an Advisory Committee for Diversity & Inclusion. The full array of CRTP activities, together with a dedicated faculty, talented cadre of trainees, and vibrant cancer research community, all contribute to producing CRTP alumni who are well- positioned to become lifelong learners and future leaders in the continually evolving field of cancer research.