Nanoscale Temperature Mapping and Thermal Regulation of Intracellular Dynamics
纳米级温度测绘和细胞内动力学的热调节
基本信息
- 批准号:10687130
- 负责人:
- 金额:$ 39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:BiologicalBiological ProcessCell physiologyCellsDevelopmentDiagnosticDiseaseEmploymentLifeMapsMeasuresMicroscopeMicroscopicMolecularOpticsOrganellesRegulationResearchSpectrum AnalysisTemperatureTherapeuticThermogenesisThermometersVariantdesignmulti-scale modelingnanoarchitecturenanoscalenovelnovel strategiesresponsespatiotemporaltoolwater environment
项目摘要
Project Summary
Temperature is critical to all life activities and regulates biological processes at
various levels. Cells not only detect temperature changes through their unique
temperature-sensitive molecular machineries but also adapt with appropriate responses
to maintain their inherent functions. Despite the fundamental involvement of temperature
in biological processes, the molecular mechanism by which cells produce and use heat
is largely unknown. Our aim to develop atomically precise nanoarchitectures as both
stimulators and thermometers to study various temperature-sensitive molecules down to
the sub-cellular level. The study will investigate spatio-temporal temperature variations,
including organelle-specific thermogenesis to develop the intrinsic connections between
temperature and cell functions. The proposed study will combine nanoarchitectures with
our recent demonstrated ultrafast optical spectroscopy, structural characterizations, and
atomistic-to-microscope multiscale modeling framework to design, measure, and
analyze the molecular-level thermal-biological interactions. The new approach will
quantify intracellular temperature changes at the microscopic level in large difference
from those assumed at a water environment at the macroscopic level. We expect the
employment of new nano-architecture will uncover novel mechanisms and fundamental
understandings of intracellular temperature-assisted functions.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yongjie Hu其他文献
Yongjie Hu的其他文献
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{{ truncateString('Yongjie Hu', 18)}}的其他基金
Nanoscale Temperature Mapping and Thermal Regulation of Intracellular Dynamics
纳米级温度测绘和细胞内动力学的热调节
- 批准号:
10502123 - 财政年份:2022
- 资助金额:
$ 39万 - 项目类别:
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