Career Enhancement Program

职业提升计划(CEP)：项目摘要/摘要 就其本质而言，平滑肌肉瘤(LMS)需要多学科的护理和研究方法。LMS是 高度侵袭性肿瘤，常出现在高分期，需要协调和整合 外科医生、放射肿瘤学家和内科肿瘤学家的护理。此外，解剖学的多样性 软组织和子宫LMS的表现部位、不同行为和分子特征 与其他多形性肉瘤的基因和表型重叠需要解剖学和 分子病理学家。这个孢子将独一无二地提供职业发展机会和 为所有这些学科的年轻调查人员提供指导。特别是，孢子CEP将招募和 促进有前途的年轻研究人员从事LMS或遗传易感性的翻译研究 用于肉瘤/LMS。孢子机制将为这些CEP获奖者提供丰富的互动机会 与关键学科的基础、翻译和临床肉瘤研究人员合作并向他们学习。 伊丽莎白·G·德米科医学博士(多伦多大学)和乔纳森·A·弗莱彻医学博士(达纳·法伯) 癌症研究所)将担任孢子CEP委员会的联席董事。CEP委员会将协助 联合董事确保CEP实现其目标，并确保获奖者在职业生涯中取得进步 发展和得到充分的指导。该委员会代表了多学科性质。 翻译肉瘤研究，在肉瘤生物学、靶点发现和 验证，基因组学，实验治疗学，生物统计学，外科，放射医学， 生物标记物和病理学。委员会成员是孢子成员的学术领袖。 具有LMS经验的机构。从与肉瘤相关的内科和外科学科来看， 妇女和少数群体的代表仍然不足。对于这个孢子来说，多样性是一个优先事项 在肉瘤研究方面得到了加强，我们努力通过纳入女性来为这一努力做出贡献 作为所有孢子委员会的成员和项目领导。 为年轻研究人员提供研究支持和受保护的时间在翻译中是必不可少的 研究，特别是在肉瘤研究，那里的资金机制很少。孢子CEP将促进 获奖者向独立研究员地位的过渡，并将优先资助以下人员的早期职业科学家 寻求通过对疾病机制的研究来提高生活质量。帮助孢子的特定目标 实现这些目标的CEP包括：1.确定和提供杰出的科学和职业指导 年轻的肉瘤研究人员；2.为临床导向的研究人员提供足够的保护时间，以方便 他们发展成为独立的翻译研究人员；3.招聘高素质的少数民族和妇女 来自不同临床和科学背景的研究人员将LMS研究转化为翻译；以及4.促进 通过鼓励年轻研究人员参加科学务虚会，开展多学科研究。

Career Enhancement Program (CEP): Project Summary / Abstract By its very nature, leiomyosarcoma (LMS) demands a multi-disciplinary approach to care and research. LMS are highly aggressive tumors, which frequently present at high stage, and require the coordinated and integrated care of surgeons, radiation oncologists, and medical oncologists. In addition, the diverse nature of the anatomic sites of presentation, the differential behavior, and molecular characteristics of soft tissue and uterine LMS, and genotypic and phenotypic overlap with other pleomorphic sarcomas demands the involvement of anatomic and molecular pathologists. This SPORE will be uniquely poised to provide career development opportunities and mentorship for young investigators in all of these disciplines. In particular, the SPORE CEP will recruit and promote promising young researchers to pursue careers in translational studies of LMS or genetic predisposition for sarcoma/LMS. The SPORE mechanism will provide these CEP awardees with rich opportunities to interact with and learn from basic, translational, and clinical sarcoma researchers from key disciplines. Elizabeth G. Demicco MD, PhD (University of Toronto), and Jonathan A. Fletcher MD (Dana Farber Cancer Institute) will serve as co-directors for the SPORE CEP committee. The CEP committee will assist the co-directors in ensuring that the CEP meets its goals and that awardees are progressing in their career development and being adequately mentored. The committee represents the multi-disciplinary nature of translational sarcoma research, with particular expertise in sarcoma biology, target discovery and validations, genomics, experimental therapeutics, biostatistics, surgery, radiation medicine, biomarkers, and pathology. The committee members are academic leaders at the SPORE member institutions with experience in LMS. As seen across sarcoma-relevant medical and surgical disciplines, women and minorities continue to be underrepresented. It is a priority for this SPORE that diversity is enhanced in sarcoma research and we have endeavored to contribute to this effort by including women as members of all SPORE Committees and in the program leadership. Providing research support and protected time for young investigators is essential in translational research, particularly in sarcoma research, where funding mechanisms are few. The SPORE CEP will facilitate transition of awardees to independent investigator status and will prioritize funding early career scientists who seek to advance quality of life through research on disease mechanisms. Specific aims that assist the SPORE CEP in achieving these goals include: 1. Identifying and providing exceptional science and career mentorship to young sarcoma researchers; 2. Enforcing adequate protected time for clinically-oriented investigators to facilitate their development into independent translational researchers; 3. Recruiting highly qualified minority and women investigators from diverse clinical and scientific backgrounds into translational LMS research; and 4. Promoting multi-disciplinary research by encouraging young investigators to participate in scientific retreats.