Career Enhancement Program

职业提升计划

• 批准号: 10705765
• 负责人: Elizabeth Demicco
• 金额: $ 8.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705765
• 关键词: Achievement; Anatomy; Area; Basic Science; Behavior; Biological Markers; Biology; Biomedical Engineering; Biometry; Cancer Biology; Caring; Characteristics; Clinical; Clinical Investigator; Committee Members; Dana-Farber Cancer Institute; Development; Diagnosis; Discipline; Disease; Disease model; Doctor of Philosophy; Ensure; Equilibrium; Faculty; Foundations; Funding; Funding Mechanisms; Genetic; Genetic Predisposition to Disease; Genomics; Genotype; Goals; In Vitro; Individual; Institution; Interdisciplinary Study; Investigational Therapies; Laboratories; Leadership; Learning; Life Expectancy; Medical; Medical Oncologist; Medical Oncology; Medicine; Mentors; Mentorship; Minority; Molecular; Nature; Operative Surgical Procedures; Pathologist; Pathology; Patients; Pediatric Oncology; Phenotype; Productivity; Qualifying; Quality of life; Radiation; Radiation Oncologist; Radiation Oncology; Records; Rejuvenation; Research; Research Personnel; Research Support; Science; Scientist; Solid; Source; Specialist; Surgeon; Surgical Oncology; Talents; Time; Training; Translational Research; Universities; Uterine Leiomyosarcoma; Validation; Woman; cancer type; care coordination; career; career development; design; experience; human capital; improved; in vitro Model; in vivo Model; innovation; insight; integrated care; interdisciplinary approach; leiomyosarcoma; member; multidisciplinary; novel strategies; novel therapeutic intervention; pressure; programs; recruit; sarcoma; soft tissue; success; translational cancer research; translational scientist; translational study; tumor

Career Enhancement Program (CEP): Project Summary / Abstract By its very nature, leiomyosarcoma (LMS) demands a multi-disciplinary approach to care and research. LMS are highly aggressive tumors, which frequently present at high stage, and require the coordinated and integrated care of surgeons, radiation oncologists, and medical oncologists. In addition, the diverse nature of the anatomic sites of presentation, the differential behavior, and molecular characteristics of soft tissue and uterine LMS, and genotypic and phenotypic overlap with other pleomorphic sarcomas demands the involvement of anatomic and molecular pathologists. This SPORE will be uniquely poised to provide career development opportunities and mentorship for young investigators in all of these disciplines. In particular, the SPORE CEP will recruit and promote promising young researchers to pursue careers in translational studies of LMS or genetic predisposition for sarcoma/LMS. The SPORE mechanism will provide these CEP awardees with rich opportunities to interact with and learn from basic, translational, and clinical sarcoma researchers from key disciplines. Elizabeth G. Demicco MD, PhD (University of Toronto), and Jonathan A. Fletcher MD (Dana Farber Cancer Institute) will serve as co-directors for the SPORE CEP committee. The CEP committee will assist the co-directors in ensuring that the CEP meets its goals and that awardees are progressing in their career development and being adequately mentored. The committee represents the multi-disciplinary nature of translational sarcoma research, with particular expertise in sarcoma biology, target discovery and validations, genomics, experimental therapeutics, biostatistics, surgery, radiation medicine, biomarkers, and pathology. The committee members are academic leaders at the SPORE member institutions with experience in LMS. As seen across sarcoma-relevant medical and surgical disciplines, women and minorities continue to be underrepresented. It is a priority for this SPORE that diversity is enhanced in sarcoma research and we have endeavored to contribute to this effort by including women as members of all SPORE Committees and in the program leadership. Providing research support and protected time for young investigators is essential in translational research, particularly in sarcoma research, where funding mechanisms are few. The SPORE CEP will facilitate transition of awardees to independent investigator status and will prioritize funding early career scientists who seek to advance quality of life through research on disease mechanisms. Specific aims that assist the SPORE CEP in achieving these goals include: 1. Identifying and providing exceptional science and career mentorship to young sarcoma researchers; 2. Enforcing adequate protected time for clinically-oriented investigators to facilitate their development into independent translational researchers; 3. Recruiting highly qualified minority and women investigators from diverse clinical and scientific backgrounds into translational LMS research; and 4. Promoting multi-disciplinary research by encouraging young investigators to participate in scientific retreats.

职业增强计划（CEP）：项目摘要 /摘要 从本质上讲，平滑肌肉瘤（LMS）需要一种多学科的护理和研究方法。 LMS是 高度侵略性的肿瘤，经常在高阶段存在，需要协调和整合 护理外科医生，辐射肿瘤学家和医学肿瘤学家。另外，解剖学的多样性 呈现位点，软组织和子宫LMS的差异行为以及分子特征，以及 基因型和表型与其他多形性肉瘤重叠需要解剖学和 分子病理学家。该孢子将被唯一准备提供职业发展机会和 所有这些学科的年轻研究人员的指导。特别是，孢子CEP将招募和 促进有前途的年轻研究人员在LMS或遗传易感性的转化研究中从事职业 对于肉瘤/LMS。孢子机制将为这些CEP获奖者提供丰富的互动机会 从关键学科的基本，转化和临床肉瘤研究人员中学习并从基本，转化和临床肉瘤研究中学习。 Elizabeth G. Demicco医学博士，博士（多伦多大学）和Jonathan A. Fletcher MD（Dana Farber 癌症研究所）将担任孢子CEP委员会的联合导演。 CEP委员会将协助 联合导演确保CEP达到目标，并且获奖者在职业生涯中正在发展 发展并得到充分的指导。委员会代表多学科性质 翻译肉瘤研究，在肉瘤生物学，目标发现和 验证，基因组学，实验治疗学，生物统计学，手术，放射医学， 生物标志物和病理学。委员会成员是孢子成员的学术领导者 具有LMS经验的机构。从与肉瘤相关的医学和外科学科中可以看出， 妇女和少数民族的人数仍然不足。这是这个孢子的优先事项，多样性是 在肉瘤研究中增强了 作为所有孢子委员会和计划领导的成员。 为年轻调查人员提供研究支持和受保护的时间至关重要 研究，特别是在肉瘤研究中，资金机制很少。孢子CEP将有助于 将获奖者过渡到独立调查员身份，并将优先考虑早期职业科学家的资金 寻求通过研究疾病机制来提高生活质量。有助于孢子的具体目标 CEP实现这些目标包括：1。识别并提供卓越的科学和职业指导 年轻的肉瘤研究人员； 2。执行足够的保护时间，以促进临床上的研究人员促进 他们发展成为独立的转化研究人员； 3。招募高素质的少数民族和妇女 来自转化LMS研究的各种临床和科学背景的研究人员；和4。促进 多学科研究通过鼓励年轻的研究人员参加科学务虚会。