THE CONTRACTOR SHALL MAINTAIN AND SUPPORT STUDY DATA INFRASTRUCTURE, DATA MANAGEMENT AND DATA PREPARATION, AND ADVANCED STATISTICAL AND BIOINFORMATICS

1.维护和支持专门针对单剂HPV疫苗试验的研究数据基础设施、数据管理和数据准备以及先进的统计和生物信息学数据分析服务(即哥斯达黎加HPV疫苗试验[CVT，ClinicalTrials.gov，NCT00128661]及其长期长期跟踪研究，对哥斯达黎加一剂或两剂双价或非有效预防性HPV疫苗[ESCUDDO，NCT03180034]，女孩单剂Cerarix疫苗或妇女三剂Gardasil疫苗预防人乳头状瘤病毒感染[Primavera，NCT03728881]，以及哥斯达黎加年轻成年妇女单剂HPV疫苗接种[PRISMA，NCT03180034]NCT05237947]。 2.为与人乳头瘤病毒自然病史、人乳头瘤病毒免疫学、人乳头瘤病毒疫苗接种和人乳头瘤病毒驱动的癌症有关的项目以及与传染病和相关疾病的流行病学和预防有关的其他活动提供数据管理和先进的统计和生物信息学数据分析支持。

Goals: 1. To maintain and support study data infrastructure, data management and data preparation, and advanced statistical and bioinformatics data analysis services specifically for the one dose HPV Vaccine trials (i.e., Costa Rica HPV Vaccine Trial [CVT, ClinicalTrials.gov, NCT00128661] and its extended long-term follow-up studies, Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines [ESCUDDO, NCT03180034], Single Dose of Cervarix Vaccine in Girls or Three Doses of Gardasil Vaccine in Women for the Prevention of Human Papillomavirus Infection [PRIMAVERA, NCT03728881], and Single-dose HPV Vaccination among young adult women in Costa Rica [PRISMA, NCT05237947]. 2. To provide data management and advanced statistical and bioinformatics data analysis support for projects related to HPV natural history, HPV immunology, HPV vaccination, and HPV-driven cancers, and other activities associated with the epidemiology and prevention of infections and related diseases.