THE CONTRACTOR SHALL MAINTAIN AND SUPPORT STUDY DATA INFRASTRUCTURE, DATA MANAGEMENT AND DATA PREPARATION, AND ADVANCED STATISTICAL AND BIOINFORMATICS

目标：1. 维护和支持研究数据基础设施、数据管理和数据准备，以及专门针对单剂HPV疫苗试验的高级统计和生物信息学数据分析服务（即，哥斯达黎加HPV疫苗试验[CVT，ClinicalTrials.gov，NCT 00128661]及其扩展的长期随访研究，一剂或两剂二价或九价预防性HPV疫苗[ESCUDDO，NCT 03180034]、女孩单剂Cervarix疫苗或女性三剂Gardasil疫苗预防人乳头瘤病毒感染的科学评价[PRIMAVERA，NCT 03728881]，和哥斯达黎加年轻成年女性中的单剂HPV疫苗接种[PRISMA，NCT 05237947]。 2. 为与HPV自然史，HPV免疫学，HPV疫苗接种和HPV驱动的癌症相关的项目以及与感染和相关疾病的流行病学和预防相关的其他活动提供数据管理和先进的统计和生物信息学数据分析支持。

Goals: 1. To maintain and support study data infrastructure, data management and data preparation, and advanced statistical and bioinformatics data analysis services specifically for the one dose HPV Vaccine trials (i.e., Costa Rica HPV Vaccine Trial [CVT, ClinicalTrials.gov, NCT00128661] and its extended long-term follow-up studies, Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines [ESCUDDO, NCT03180034], Single Dose of Cervarix Vaccine in Girls or Three Doses of Gardasil Vaccine in Women for the Prevention of Human Papillomavirus Infection [PRIMAVERA, NCT03728881], and Single-dose HPV Vaccination among young adult women in Costa Rica [PRISMA, NCT05237947]. 2. To provide data management and advanced statistical and bioinformatics data analysis support for projects related to HPV natural history, HPV immunology, HPV vaccination, and HPV-driven cancers, and other activities associated with the epidemiology and prevention of infections and related diseases.