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Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression

Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression
剖析芬太尼引起呼吸抑制的中枢和外周机制
批准号：
10831159
负责人：
Jose A Moron-Concepcion
金额：
$44.25万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
已结题
起止时间：
2023-07-01 至 2024-06-30
来源：
https://reporter.nih.gov/project-details/10831159
关键词：
AccidentsAcuteAmericanAttenuatedBindingBrainBrain StemCessation of lifeChestChest wall structureConsciousDataDoseElectrodesEmergency SituationEpidemicFDA approvedFentanylGeneticGoalsHeroinHypoxiaIntercostal MusclesInterventionIntravenousIntubationKineticsLaryngismusLinkMaintenanceMeasuresMediatorMental DepressionModelingMuscleMuscle RigidityNaloxoneNeuronsNucleus solitariusOpioidOpioid AntagonistOrganOutcomeOverdoseOxycodonePatientsPeripheralPositioning AttributePreventionRattusRecoveryRespiratory CenterRespiratory DiaphragmRespiratory MusclesRodentSensorySignal TransductionSpasmTestingVagus nerve structureVentilatory DepressionVisceralanaloggenetic approachhigh riskin vivolocus ceruleus structuremu opioid receptorsneurotransmissionnoradrenergicnovel therapeutic interventionopioid overdoseopioid use disorderoverdose deathpreventresponsesevere injuryspasticitysynthetic opioidvocal cord

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中文摘要
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英文摘要
In this application we propose studies to assess how fentanyl complicates treatment of opioid overdose. In addition, our proposed studies might establish the mechanisms underlying fentanyl-induced respiratory depression. Overall, findings generated in this proposal will eventually lead to develop new therapeutic interventions to prevent and rescue fentanyl-induced fatal overdoses.
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