Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression

剖析芬太尼引起呼吸抑制的中枢和外周机制

• 批准号: 10831159
• 负责人: Jose A Moron-Concepcion
• 金额: $ 44.25万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10831159
• 关键词: Accidents; Acute; American; Attenuated; Binding; Brain; Brain Stem; Cessation of life; Chest; Chest wall structure; Conscious; Data; Dose; Electrodes; Emergency Situation; Epidemic; FDA approved; Fentanyl; Genetic; Goals; Heroin; Hypoxia; Intercostal Muscles; Intervention; Intravenous; Intubation; Kinetics; Laryngismus; Link; Maintenance; Measures; Mediator; Mental Depression; Modeling; Muscle; Muscle Rigidity; Naloxone; Neurons; Nucleus solitarius; Opioid; Opioid Antagonist; Organ; Outcome; Overdose; Oxycodone; Patients; Peripheral; Positioning Attribute; Prevention; Rattus; Recovery; Respiratory Center; Respiratory Diaphragm; Respiratory Muscles; Rodent; Sensory; Signal Transduction; Spasm; Testing; Vagus nerve structure; Ventilatory Depression; Visceral; analog; genetic approach; high risk; in vivo; locus ceruleus structure; mu opioid receptors; neurotransmission; noradrenergic; novel therapeutic intervention; opioid overdose; opioid use disorder; overdose death; prevent; response; severe injury; spasticity; synthetic opioid; vocal cord

In this application we propose studies to assess how fentanyl complicates treatment of opioid overdose. In addition, our proposed studies might establish the mechanisms underlying fentanyl-induced respiratory depression. Overall, findings generated in this proposal will eventually lead to develop new therapeutic interventions to prevent and rescue fentanyl-induced fatal overdoses.

在本申请中，我们提出研究来评估芬太尼如何使阿片类药物过量的治疗复杂化。此外，我们提出的研究可能建立芬太尼诱导的呼吸抑制的机制。总体而言，该提案中的发现最终将导致开发新的治疗干预措施，以预防和挽救芬太尼引起的致命过量用药。