Sustained Delivery of RhoA activator for Treatment of Intervertebral Disc Degeneration

持续递送 RhoA 激活剂治疗椎间盘退变

• 批准号: 10829719
• 负责人: Ambika Goel Bajpayee
• 金额: $ 9.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-07 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10829719
• 关键词: Actomyosin; Award; Back Pain; Biomedical Research; Cells; Engineering; Ethnic Population; Goals; Guidelines; Intervertebral disc structure; Medicine; Mentors; Musculoskeletal; Orthopedics; Pain; Parents; Patient-Focused Outcomes; Pharmaceutical Preparations; Physicians; Postbaccalaureate; Research; Research Project Grants; Research Training; Scientist; Signal Transduction; Students; Therapeutic; United States National Institutes of Health; Universities; Vertebral column; age effect; career; disability; discogenic pain; experience; improved outcome; intervertebral disk degeneration; patient subsets; racial population; regenerative therapy

This application is for a diversity supplement for a post-baccalaureate student who will be doing a year-long mentored research experience in the lab of the PI, Dr. Nadeen Chahine’s on a research project related to this NIH parent award. The candidate’s career goals are to become a physician scientist, specializing in orthopedics and musculoskeletal medicine. The candidate is an engineer (U.S. citizen) from an underrepresented race/ethnic group in STEM, as defined by the guidelines provided by NSF and NIH on workforce diversity. The candidate’s research training in orthopedic research at Columbia University enhances the diversity of the biomedical research workforce. The diversity supplement project will examine the effects of aging and degeneration on RhoA signaling and actomyosin contractility of IVD. The diversity supplement project is a direct extension of the scope of the parent R21 project on sustained delivery of RhoA activator for treatment of intervertebral disc (IVD) degeneration. This project is expected to advance therapeutic treatment of disc degeneration and back pain.

这个应用程序是一个多元化的补充后学士学位的学生谁将做 在PI实验室长达一年的指导研究经验，Nadeen Chahine博士在一个 与NIH家长奖有关的研究项目。候选人的职业目标是成为 医生科学家，专门从事骨科和肌肉骨骼医学。候选人是 来自STEM中代表性不足的种族/族裔群体的工程师（美国公民），定义如下： NSF和NIH提供的关于劳动力多样性的指导方针。候选人的研究训练 在哥伦比亚大学的整形外科研究中， 劳动力多样性补充项目将检查老化和退化的影响 对RhoA信号和IVD肌动球蛋白收缩性的影响。多样性补充项目是一个直接的 扩大关于持续提供RhoA激活剂的母R21项目的范围， 椎间盘（IVD）退变的治疗。该项目有望推进 椎间盘退变和背痛的治疗性治疗。