Sustained Delivery of RhoA activator for Treatment of Intervertebral Disc Degeneration

这份申请是为即将毕业的研究生提供的多样性补充。 在PI实验室长达一年的指导研究经验，Nadeen Chahine博士在 与NIH家长奖相关的研究项目。候选人的职业目标是成为一名 内科科学家，专门从事骨科和肌肉骨骼医学。候选人是 来自STEM中代表性不足的种族/民族的工程师(美国公民)，定义如下 NSF和NIH提供的关于劳动力多样性的指导方针。应聘者的研究训练 在哥伦比亚大学进行的整形外科研究增强了生物医学研究的多样性 劳动力。多样性补充项目将研究衰老和退化的影响。 RhoA信号与IVD肌动球蛋白收缩的关系多样性补充项目是一个直接的 扩大母公司R21项目持续交付RhoA激活剂的范围 治疗腰椎间盘退变。这项工程有望取得进展 治疗腰椎间盘退变和腰背痛。

This application is for a diversity supplement for a post-baccalaureate student who will be doing a year-long mentored research experience in the lab of the PI, Dr. Nadeen Chahine’s on a research project related to this NIH parent award. The candidate’s career goals are to become a physician scientist, specializing in orthopedics and musculoskeletal medicine. The candidate is an engineer (U.S. citizen) from an underrepresented race/ethnic group in STEM, as defined by the guidelines provided by NSF and NIH on workforce diversity. The candidate’s research training in orthopedic research at Columbia University enhances the diversity of the biomedical research workforce. The diversity supplement project will examine the effects of aging and degeneration on RhoA signaling and actomyosin contractility of IVD. The diversity supplement project is a direct extension of the scope of the parent R21 project on sustained delivery of RhoA activator for treatment of intervertebral disc (IVD) degeneration. This project is expected to advance therapeutic treatment of disc degeneration and back pain.