Sustained Delivery of RhoA activator for Treatment of Intervertebral Disc Degeneration

持续递送 RhoA 激活剂治疗椎间盘退变

• 批准号: 10829719
• 负责人: Ambika Goel Bajpayee
• 金额: $ 9.51万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-07 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10829719
• 关键词: Actomyosin; Award; Back Pain; Biomedical Research; Cells; Engineering; Ethnic Population; Goals; Guidelines; Intervertebral disc structure; Medicine; Mentors; Musculoskeletal; Orthopedics; Pain; Parents; Patient-Focused Outcomes; Pharmaceutical Preparations; Physicians; Postbaccalaureate; Research; Research Project Grants; Research Training; Scientist; Signal Transduction; Students; Therapeutic; United States National Institutes of Health; Universities; Vertebral column; age effect; career; disability; discogenic pain; experience; improved outcome; intervertebral disk degeneration; patient subsets; racial population; regenerative therapy

This application is for a diversity supplement for a post-baccalaureate student who will be doing a year-long mentored research experience in the lab of the PI, Dr. Nadeen Chahine’s on a research project related to this NIH parent award. The candidate’s career goals are to become a physician scientist, specializing in orthopedics and musculoskeletal medicine. The candidate is an engineer (U.S. citizen) from an underrepresented race/ethnic group in STEM, as defined by the guidelines provided by NSF and NIH on workforce diversity. The candidate’s research training in orthopedic research at Columbia University enhances the diversity of the biomedical research workforce. The diversity supplement project will examine the effects of aging and degeneration on RhoA signaling and actomyosin contractility of IVD. The diversity supplement project is a direct extension of the scope of the parent R21 project on sustained delivery of RhoA activator for treatment of intervertebral disc (IVD) degeneration. This project is expected to advance therapeutic treatment of disc degeneration and back pain.

该申请旨在为将从事以下工作的学士后学生提供多元化补充 Nadeen Chahine 博士在 PI 实验室中获得了为期一年的指导研究经验 与该 NIH 家长奖相关的研究项目。候选人的职业目标是成为 医师科学家，专门研究骨科和肌肉骨骼医学。候选人是 来自 STEM 领域代表性不足的种族/民族的工程师（美国公民），定义如下 NSF 和 NIH 提供的关于劳动力多样性的指南。候选人的研究培训 哥伦比亚大学骨科研究增强了生物医学研究的多样性 劳动力。多样性补充项目将研究衰老和退化的影响 IVD 的 RhoA 信号传导和肌动球蛋白收缩性。多样性补充项目是一个直接的 扩大母公司 R21 项目的范围，即持续提供 RhoA 激活剂 治疗椎间盘（IVD）退变。该项目预计将推进 椎间盘退变和背痛的治疗。