Feasibility of app-delivered circadian synchronization therapy with light in a cohort of pregnant women

应用程序提供的光昼夜节律同步治疗对孕妇队列的可行性

• 批准号: 10823065
• 负责人: Olivia Walch
• 金额: $ 29.51万
• 依托单位: ARCASCOPE, INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-11 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10823065
• 关键词: Adult; Algorithms; Android; Apple watch; Behavior; Behavioral; Businesses; Caffeine; Circadian Dysregulation; Circadian Rhythms; Clinical Trials; Collection; Data; Dedications; Development; Elements; Exercise; Exposure to; Fatigue; Feedback; Gestational Diabetes; Glass; Goals; Health; Hour; Individual; Infant; Intervention; Light; Lighting; Link; Malignant Neoplasms; Maternal Health; Moods; Mothers; Napping; Outcome; Phase; Play; Population Heterogeneity; Population Intervention; Postpartum Depression; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Recommendation; Reporting; Research; Risk; Risk Reduction; Role; Sleep; Small Business Innovation Research Grant; Small Business Technology Transfer Research; System; Testing; Time; Training; Travel; Update; Work; circadian; circadian pacemaker; cohort; diagnostic technologies; diaries; improved; improved outcome; innovation; interest; mobile application; patient population; personalized intervention; post pregnancy; pregnant; prevent; prototype; real time monitoring; response; sensor; smartphone application; socioeconomics; success; technological innovation; usability

PROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthened and aligned to the 24-hour day by light, and environmental light manipulations can shift the phase and alter the amplitude of circadian rhythms when based on careful timing and combined with other behaviors. This Phase I STTR project aims to evaluate the feasibility of circadian synchronization therapy with light (CST-L) in a socioeconomically diverse population of pregnant women. The intervention involves bright light exposure at specific times to phase advance, delay, or boost the amplitude of the circadian clock, dim light at other times, as well as the use of a diary to track the causes of circadian disruption. To evaluate the success of the trial, we will collect subjective feedback from 20 pregnant women using the app and blue-blocking glasses for four weeks, and will make iterative updates to the app in response to user feedback. The ultimate goal is to develop a mobile application for both iOS and Android that delivers CST-L and helps improve maternal mood and health, as well as infant sleep training. If successful, this intervention could help reduce the risk of preterm birth, postpartum depression, and other poor outcomes during and after pregnancy.

项目总结