Feasibility of app-delivered circadian synchronization therapy with light in a cohort of pregnant women

项目摘要 昼夜节律在促进孕产妇健康和管理妊娠结局方面发挥着至关重要的作用，包括 妊娠糖尿病、早产和产后抑郁症。然而，缓解昼夜节律的干预措施 妊娠期间缺乏节律中断，尽管有现成的非药物昼夜节律 干预措施。昼夜节律计时系统通过光线得到加强并与24小时一致， 环境光操纵可以改变相位并改变昼夜节律的幅度， 并与其他行为相结合。 这个I期STTR项目旨在评估光同步昼夜节律治疗的可行性 （CST-L）在社会经济多样化的孕妇人群中。干预涉及明亮的光线 在特定时间暴露于相位提前、延迟或提高生物钟的振幅， 其他时间，以及使用日记来跟踪昼夜节律紊乱的原因。评价…的成功 在试验中，我们将收集20名使用该应用程序和防蓝光眼镜的孕妇的主观反馈 为期四周，并将根据用户反馈对应用程序进行迭代更新。最终目标是 为iOS和Android开发一个移动的应用程序，提供CST-L，帮助改善产妇情绪 和健康，以及婴儿睡眠训练。如果成功，这种干预可能有助于降低早产的风险。 分娩，产后抑郁症和其他妊娠期间和妊娠后的不良结局。

PROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthened and aligned to the 24-hour day by light, and environmental light manipulations can shift the phase and alter the amplitude of circadian rhythms when based on careful timing and combined with other behaviors. This Phase I STTR project aims to evaluate the feasibility of circadian synchronization therapy with light (CST-L) in a socioeconomically diverse population of pregnant women. The intervention involves bright light exposure at specific times to phase advance, delay, or boost the amplitude of the circadian clock, dim light at other times, as well as the use of a diary to track the causes of circadian disruption. To evaluate the success of the trial, we will collect subjective feedback from 20 pregnant women using the app and blue-blocking glasses for four weeks, and will make iterative updates to the app in response to user feedback. The ultimate goal is to develop a mobile application for both iOS and Android that delivers CST-L and helps improve maternal mood and health, as well as infant sleep training. If successful, this intervention could help reduce the risk of preterm birth, postpartum depression, and other poor outcomes during and after pregnancy.