Regulating axon guidance through local translation at adhesions

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PROJECT SUMMARY This Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) is to support Jordan Headen to pursue predoctoral training in my laboratory. This proposal is a supplement to my currently funded NIH R01 award (NS125146). In the proposal, we provide a summary of the original (parent) R01, a research plan for the candidate, a career development plan for the candidate, and the PI’s qualifications to mentor the candidate. Ms. Headen completed her Bachelor of Science degree in Biology at Ball State University. During her undergraduate, she worked in the Neuroscience laboratory of Dr. Ashley Kalinski, examining molecular mechanisms contributing to neuroinflammation after nerve injury. As an undergraduate, Ms. Headen published one co-authored publication. Ms. Headen’s long-term career plans are to become an independent faculty member in academia with a research focus on neuroscience. This supplement will provide Ms. Headen with extensive research experience in molecular and cellular neurobiology, focusing on mechanisms underlying local translation during axon guidance. Furthermore, this supplement will provide Ms. Headen with focused career development training. Overall, this supplement will provide the training needed to submit a strong F31 application at the beginning of her third year in the Ph.D. program and help her achieve her goal of becoming a neuroscience professor in academia.