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中文摘要
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管理核心-摘要 “UTMB-诺华大流行防范联盟(UNAPP)”结合了UTMB在病毒学方面的卓越表现, 和BSL 4/3设施,利用诺华在药物发现和开发方面的实力,提供大流行抗病毒药物。的 行政核心提供充分实现影响所需的领导和方案协调 这一独特的学术-工业合作伙伴关系,并满足抗病毒药物发现中心的目标, 引起关注的流行病病原体。我们将通过以下四个目标来实现这一目标:实施 综合的组织治理和方案结构,将促进团队科学方法, 用于针对冠状病毒、黄病毒和亨尼帕病毒的大流行预防的抗病毒药物发现; ii. 在科学、业务、财务、知识产权保护和 通过凝聚力和协作性治理进行沟通; iii.实施发展性研究 项目计划,将扩大中心的范围和研究范围,同时鼓励外部 研究人员在抗病毒药物研发方面开发新技术和创新的研究思路;以及iv. 实施旨在增加合格的早期职业研究人员的可用性的指导项目计划 通过提供职业发展和指导研究, 专业进步。
英文摘要
ADMINISTRATIVE CORE - ABSTRACT The “UTMB-Novartis Alliance for Pandemic Preparedness (UNAPP)” combines UTMB’s excellence in virology & BSL4/3 facility with Novartis’ power in drug discovery & development to deliver pandemic antivirals. The Administrative Core provides the leadership and programmatic coordination required to fully realize the impact of this unique academic-industry partnership and meet the goals of the Antiviral Drug Discovery Centers for Pathogens of Pandemics Concern. We will accomplish this through the following four aims: i. implement an integrated organizational governance and programmatic structure that will promote a team science approach to antiviral drug discovery for pandemic prevention against Coronaviruses, Flaviviruses, and Henipaviruses; ii. provide integrated decision making in scientific, operational, financial, intellectual property protection and communication through cohesive and collaborative governance; iii. implement a Developmental Research Project program that will expand the center's scope and range of research while encouraging outside investigators to develop novel technology and innovative research ideas in antiviral drug discovery; and iv. implement a Mentored Project program designed to increase the availability of qualified early career researchers in antiviral discovery research by providing career development and mentored research to further their professional advancement.
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Administrative Core
Discovery of novel broad-spectrum coronavirus inhibitors
Discovery of novel broad-spectrum coronavirus inhibitors
Identifying host and viral correlates for coronavirus pathogenesis
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