RFA-GH-20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru

RFA-GH-20-005,在秘鲁进行综合传染病和公共卫生研究

基本信息

  • 批准号:
    10842492
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2025-09-29
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY: The proposed application aims to overcome diagnostic barriers in the etiologic diagnosis of endemic and epidemic causes of acute febrile illness (AFI) by moving efficient state of the art diagnostics to an area of high endemicity. The long-term goal of this research is to understand the etiology of AFI across diverse contexts in South America and contribute to global strategies that improve etiology-specific disease estimates to inform public health practice and policy. The central hypothesis is that the technology transfer and implementation of improved diagnostics will enhance regional diagnostic capacity, epidemic responsiveness, and translation of research findings to practice maximizing the public health impact of research findings. The rationale for the research is that the documented feasibility of this approach will enable a full and appropriate evaluation for uptake by regional and national stakeholders. The goals of the research will be achieved through the execution of three specific aims: 1) Establish stable year round acute febrile illness surveillance using the TaqMan array card, which simultaneously detects over 30 pathogens of AFI across three epidemiologic contexts in Loreto, Peru; urban, riverine with extensive sylvatic exposure, and agricultural riverine context along the three country border (Peru, Brazil, and Colombia) in order to capture the diversity of pathogens causing AFI in Peru over a four year period; 2) Integrate this diagnostic platform into the regional outbreak response to determine the etiology of epidemics of acute febrile illness and validating improved storage and transport procedures; and 3) Develop and evaluate novel serodiagnostic chip to enable single platform serologic assessment and downstream point of care tests and focused diagnostics for pathogens of high prevalence and importance. The global control of emerging infectious diseases will be improved only as the areas that are not reached and included effectively in surveillance shrink and the proposed project attempts to implement a strategy to make all populations reachable to the improved diagnostics. The complexity of current diagnostic strategies is a critical barrier to the timely regional ascertainment of the etiology of most cases of acute febrile illnesses and this has important regional and global public health implications as undiagnosed AFI allows for the widespread dissemination of emerging diseases as effective disease control measures are based on accurate etiologic assessment. The plan is innovative because of the meaningful integration of highly select local researchers, educators, trainees, and policymakers. The implementation of the research strategy will be significant because it is expected to contribute to the accuracy of etiologic assessment of endemic and epidemic etiologies of AFI in an area of documented diversity of vector-borne and zoonotic agents and serve as a model for enabling local diagnostic and reporting capacity in South America.
项目总结:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Margaret N Kosek其他文献

Epidemiology of emShigella/em species and serotypes in children: a retrospective substudy of the MAL-ED observational birth cohort study
儿童中志贺氏菌属物种和血清型的流行病学:MAL-ED 观察性出生队列研究的回顾性亚研究
  • DOI:
    10.1016/j.lanmic.2024.101064
  • 发表时间:
    2025-06-01
  • 期刊:
  • 影响因子:
    20.400
  • 作者:
    Elizabeth T Rogawski McQuade;Jie Liu;Mustafa Mahfuz;Alexandre Havt;Tintu Varghese;Jasmin Shrestha;Furqan Kabir;Pablo Peñataro Yori;Amidou Samie;Queen Saidi;Adil Kalam;Fatima Aziz;Sahrish Muneer;Rashidul Haque;Aldo A M Lima;Maheswari Kalaivanan;Sanjaya Shrestha;Najeeha Talat Iqbal;Zulfiqar Bhutta;Margaret N Kosek;Eric R Houpt
  • 通讯作者:
    Eric R Houpt
Spatiotemporal variation in risk of emShigella/em infection in childhood: a global risk mapping and prediction model using individual participant data
儿童时期志贺氏菌感染风险的时空变化:使用个体参与者数据的全球风险绘图和预测模型
  • DOI:
    10.1016/s2214-109x(22)00549-6
  • 发表时间:
    2023-03-01
  • 期刊:
  • 影响因子:
    18.000
  • 作者:
    Hamada S Badr;Josh M Colston;Nhat-Lan H Nguyen;Yen Ting Chen;Eleanor Burnett;Syed Asad Ali;Ajit Rayamajhi;Syed M Satter;Nguyen Van Trang;Daniel Eibach;Ralf Krumkamp;Jürgen May;Ayola Akim Adegnika;Gédéon Prince Manouana;Peter Gottfried Kremsner;Roma Chilengi;Luiza Hatyoka;Amanda K Debes;Jerome Ateudjieu;Abu S G Faruque;Margaret N Kosek
  • 通讯作者:
    Margaret N Kosek
A cross-sectional study of associations between the sup13/supC-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy
一项关于¹³C - 蔗糖呼气试验、乳果糖鼠李糖检测与环境性肠病高风险儿童生长发育之间关联的横断面研究
  • DOI:
    10.1016/j.ajcnut.2024.10.001
  • 发表时间:
    2024-12-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Nirupama Shivakumar;Sayeeda Huq;Maribel Paredes-Olortegui;Silvenus Ochieng Konyole;Sarita Devi;Roger Yazbeck;Victor O Owino;Andrew F Brouwer;Margaret N Kosek;Paul Kelly;Douglas J Morrison;Gwenyth O Lee
  • 通讯作者:
    Gwenyth O Lee

Margaret N Kosek的其他文献

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{{ truncateString('Margaret N Kosek', 18)}}的其他基金

Capacity building in climate and health in the Peruvian Amazon
秘鲁亚马逊地区气候和健康方面的能力建设
  • 批准号:
    10838170
  • 财政年份:
    2023
  • 资助金额:
    $ 10万
  • 项目类别:
Genomic features of host adaptation of Campylobacter in low-income settings
低收入环境中弯曲杆菌宿主适应的基因组特征
  • 批准号:
    10615827
  • 财政年份:
    2022
  • 资助金额:
    $ 10万
  • 项目类别:
Genomic features of host adaptation of Campylobacter in low-income settings
低收入环境中弯曲杆菌宿主适应的基因组特征
  • 批准号:
    10452900
  • 财政年份:
    2022
  • 资助金额:
    $ 10万
  • 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
  • 批准号:
    10371146
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
  • 批准号:
    10600981
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
  • 批准号:
    10184256
  • 财政年份:
    2021
  • 资助金额:
    $ 10万
  • 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
  • 批准号:
    10259643
  • 财政年份:
    2020
  • 资助金额:
    $ 10万
  • 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
  • 批准号:
    10425210
  • 财政年份:
    2020
  • 资助金额:
    $ 10万
  • 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
  • 批准号:
    10462449
  • 财政年份:
    2020
  • 资助金额:
    $ 10万
  • 项目类别:
Enabling Infectious Disease Research Capacity in the Peruvian Amazon
增强秘鲁亚马逊地区的传染病研究能力
  • 批准号:
    10456387
  • 财政年份:
    2018
  • 资助金额:
    $ 10万
  • 项目类别:

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RFA-GH-20-005, Project of Febrile Illness Surveillance in the Andean and Amazon Countries (PISAAC)
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  • 批准号:
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  • 批准号:
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  • 批准号:
    6586448
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    6477517
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