RFA-GH-20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
RFA-GH-20-005,在秘鲁进行综合传染病和公共卫生研究
基本信息
- 批准号:10842492
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-09-29
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY:
The proposed application aims to overcome diagnostic barriers in the etiologic diagnosis of endemic and
epidemic causes of acute febrile illness (AFI) by moving efficient state of the art diagnostics to an area of high
endemicity. The long-term goal of this research is to understand the etiology of AFI across diverse contexts in
South America and contribute to global strategies that improve etiology-specific disease estimates to inform
public health practice and policy. The central hypothesis is that the technology transfer and implementation of
improved diagnostics will enhance regional diagnostic capacity, epidemic responsiveness, and translation of
research findings to practice maximizing the public health impact of research findings. The rationale for the
research is that the documented feasibility of this approach will enable a full and appropriate evaluation for
uptake by regional and national stakeholders. The goals of the research will be achieved through the execution
of three specific aims: 1) Establish stable year round acute febrile illness surveillance using the TaqMan array
card, which simultaneously detects over 30 pathogens of AFI across three epidemiologic contexts in Loreto,
Peru; urban, riverine with extensive sylvatic exposure, and agricultural riverine context along the three country
border (Peru, Brazil, and Colombia) in order to capture the diversity of pathogens causing AFI in Peru over a
four year period; 2) Integrate this diagnostic platform into the regional outbreak response to determine the
etiology of epidemics of acute febrile illness and validating improved storage and transport procedures; and 3)
Develop and evaluate novel serodiagnostic chip to enable single platform serologic assessment and downstream
point of care tests and focused diagnostics for pathogens of high prevalence and importance. The global control
of emerging infectious diseases will be improved only as the areas that are not reached and included effectively
in surveillance shrink and the proposed project attempts to implement a strategy to make all populations
reachable to the improved diagnostics. The complexity of current diagnostic strategies is a critical barrier to the
timely regional ascertainment of the etiology of most cases of acute febrile illnesses and this has important
regional and global public health implications as undiagnosed AFI allows for the widespread dissemination of
emerging diseases as effective disease control measures are based on accurate etiologic assessment. The plan
is innovative because of the meaningful integration of highly select local researchers, educators, trainees, and
policymakers. The implementation of the research strategy will be significant because it is expected to contribute
to the accuracy of etiologic assessment of endemic and epidemic etiologies of AFI in an area of documented
diversity of vector-borne and zoonotic agents and serve as a model for enabling local diagnostic and reporting
capacity in South America.
项目总结:
拟议的应用旨在克服地方性和地方性疾病病因诊断方面的诊断障碍。
通过将高效的最先进的诊断技术转移到一个高风险的地区,导致急性发热性疾病(AFI)的流行原因
地方性。这项研究的长期目标是在不同的背景下了解AFI的病因
并为改善特定病因学疾病估计的全球战略做出贡献,以告知
公共卫生实践和政策。中心假设是,技术转让和实施
改进的诊断将增强区域诊断能力、流行病反应能力和翻译
研究成果以实践最大限度地发挥研究成果对公众健康的影响。该计划的基本原理
研究表明,这种方法的记录可行性将使全面和适当的评估
区域和国家利益攸关方的理解。研究的目标将通过执行来实现
三个具体目标:1)使用TaqMan阵列建立全年稳定的急性发热病监测
CARD在洛雷托的三个流行病学背景下同时检测30多种AFI病原体,
秘鲁;三个国家沿线的城市、河流和农业河流环境
边境(秘鲁、巴西和哥伦比亚),以捕捉在秘鲁引起AFI的病原体的多样性
四年期间;2)将这一诊断平台纳入区域疫情应对,以确定
急性发热性疾病流行的病原学和验证改进的储存和运输程序;以及3)
开发和评估新的血清诊断芯片,以实现单平台血清学评估和下游
对高流行率和高重要性的病原体进行护理点测试和重点诊断。全球控制
只有当新发传染病没有得到有效覆盖和纳入时,新发传染病的情况才会得到改善
在监测方面缩减,拟议的项目试图实施一项战略,使所有人口
可获得改进的诊断。当前诊断策略的复杂性是阻碍
及时确定大多数急性发热性疾病的病因,这具有重要的意义
未诊断的AFI对区域和全球公共卫生的影响允许广泛传播
新出现的疾病作为有效的疾病控制措施,是建立在准确的病原学评估基础上的。这个计划
具有创新性,因为高度精选的当地研究人员、教育工作者、受训人员和
政策制定者。研究战略的实施将具有重大意义,因为预计它将有助于
对有文件记载的地区AFI流行病原学评估的准确性
病媒和人畜共患病病原体的多样性,并作为促进当地诊断和报告的模式
南美的运力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Margaret N Kosek其他文献
Epidemiology of emShigella/em species and serotypes in children: a retrospective substudy of the MAL-ED observational birth cohort study
儿童中志贺氏菌属物种和血清型的流行病学:MAL-ED 观察性出生队列研究的回顾性亚研究
- DOI:
10.1016/j.lanmic.2024.101064 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:20.400
- 作者:
Elizabeth T Rogawski McQuade;Jie Liu;Mustafa Mahfuz;Alexandre Havt;Tintu Varghese;Jasmin Shrestha;Furqan Kabir;Pablo Peñataro Yori;Amidou Samie;Queen Saidi;Adil Kalam;Fatima Aziz;Sahrish Muneer;Rashidul Haque;Aldo A M Lima;Maheswari Kalaivanan;Sanjaya Shrestha;Najeeha Talat Iqbal;Zulfiqar Bhutta;Margaret N Kosek;Eric R Houpt - 通讯作者:
Eric R Houpt
Spatiotemporal variation in risk of emShigella/em infection in childhood: a global risk mapping and prediction model using individual participant data
儿童时期志贺氏菌感染风险的时空变化:使用个体参与者数据的全球风险绘图和预测模型
- DOI:
10.1016/s2214-109x(22)00549-6 - 发表时间:
2023-03-01 - 期刊:
- 影响因子:18.000
- 作者:
Hamada S Badr;Josh M Colston;Nhat-Lan H Nguyen;Yen Ting Chen;Eleanor Burnett;Syed Asad Ali;Ajit Rayamajhi;Syed M Satter;Nguyen Van Trang;Daniel Eibach;Ralf Krumkamp;Jürgen May;Ayola Akim Adegnika;Gédéon Prince Manouana;Peter Gottfried Kremsner;Roma Chilengi;Luiza Hatyoka;Amanda K Debes;Jerome Ateudjieu;Abu S G Faruque;Margaret N Kosek - 通讯作者:
Margaret N Kosek
A cross-sectional study of associations between the sup13/supC-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy
一项关于¹³C - 蔗糖呼气试验、乳果糖鼠李糖检测与环境性肠病高风险儿童生长发育之间关联的横断面研究
- DOI:
10.1016/j.ajcnut.2024.10.001 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:6.900
- 作者:
Nirupama Shivakumar;Sayeeda Huq;Maribel Paredes-Olortegui;Silvenus Ochieng Konyole;Sarita Devi;Roger Yazbeck;Victor O Owino;Andrew F Brouwer;Margaret N Kosek;Paul Kelly;Douglas J Morrison;Gwenyth O Lee - 通讯作者:
Gwenyth O Lee
Margaret N Kosek的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Margaret N Kosek', 18)}}的其他基金
Capacity building in climate and health in the Peruvian Amazon
秘鲁亚马逊地区气候和健康方面的能力建设
- 批准号:
10838170 - 财政年份:2023
- 资助金额:
$ 10万 - 项目类别:
Genomic features of host adaptation of Campylobacter in low-income settings
低收入环境中弯曲杆菌宿主适应的基因组特征
- 批准号:
10615827 - 财政年份:2022
- 资助金额:
$ 10万 - 项目类别:
Genomic features of host adaptation of Campylobacter in low-income settings
低收入环境中弯曲杆菌宿主适应的基因组特征
- 批准号:
10452900 - 财政年份:2022
- 资助金额:
$ 10万 - 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
- 批准号:
10371146 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
- 批准号:
10600981 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries
弯曲杆菌的基因组流行病学可改善中低收入国家的疾病控制
- 批准号:
10184256 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
- 批准号:
10259643 - 财政年份:2020
- 资助金额:
$ 10万 - 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
- 批准号:
10425210 - 财政年份:2020
- 资助金额:
$ 10万 - 项目类别:
GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru
GH20-005,在秘鲁进行综合传染病和公共卫生研究
- 批准号:
10462449 - 财政年份:2020
- 资助金额:
$ 10万 - 项目类别:
Enabling Infectious Disease Research Capacity in the Peruvian Amazon
增强秘鲁亚马逊地区的传染病研究能力
- 批准号:
10456387 - 财政年份:2018
- 资助金额:
$ 10万 - 项目类别:
相似国自然基金
GH6783合金国产工程化及β相组织演化规律研究及产业化升级
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
2'-O-GH通过拮抗TSH受体治疗Graves眼病的作用及其机制研究
- 批准号:
- 批准年份:2024
- 资助金额:15.0 万元
- 项目类别:省市级项目
GH5家族蛋白MoEg3参与稻瘟病菌致病的机制研究
- 批准号:
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
PFOS 及 6:2Cl-PFESA 经 GH/IGF 轴干扰钱塘
江特色鲤科鱼类生长的毒性机制研究
- 批准号:HZY24C190005
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
陆地棉抗黄萎病Gh_FBLA05基因的育种应用及调控网络解析
- 批准号:32460469
- 批准年份:2024
- 资助金额:32 万元
- 项目类别:地区科学基金项目
Delta 相特征对 GH4169 合金热变形性能作用
机理的原位研究
- 批准号:Q24E010006
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
GH10家族木聚糖酶loop3双正向调控酶热稳定性与催化效率
的分子机制研究
- 批准号:
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于变形损伤控制机制的GH4169及焊接接头的蠕变-疲劳-临氢环境下寿命预测研究
- 批准号:52375371
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
马铃薯块茎蛾肠道共生Glutamicibacter halophytocola GH202103 降解马铃薯糖苷生物碱的机制研究
- 批准号:32360711
- 批准年份:2023
- 资助金额:32.00 万元
- 项目类别:地区科学基金项目
GH2132合金氮氧复合表面处理技术的工艺创新及其机理研究
- 批准号:CSTB2023NSCQ-MSX0484
- 批准年份:2023
- 资助金额:10.0 万元
- 项目类别:省市级项目
相似海外基金
RFA-GH-20-005, Project of Febrile Illness Surveillance in the Andean and Amazon Countries (PISAAC)
RFA-GH-20-005,安第斯和亚马逊国家发热性疾病监测项目 (PISAAC)
- 批准号:
10669093 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
PHASE III STUDY OF NUTROPIN THERAPY IN PUBERTAL CHILDREN WITH GH DEFICIENCY
生长激素缺乏症青春期儿童 Nutropin 治疗的 III 期研究
- 批准号:
6578990 - 财政年份:2002
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6586448 - 财政年份:2002
- 资助金额:
$ 10万 - 项目类别:
PHASE III STUDY OF NUTROPIN THERAPY IN PUBERTAL CHILDREN WITH GH DEFICIENCY
生长激素缺乏症青春期儿童 Nutropin 治疗的 III 期研究
- 批准号:
6477517 - 财政年份:2001
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6574415 - 财政年份:2001
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6505218 - 财政年份:2000
- 资助金额:
$ 10万 - 项目类别:
PHASE III STUDY OF NUTROPIN THERAPY IN PUBERTAL CHILDREN WITH GH DEFICIENCY
生长激素缺乏症青春期儿童 Nutropin 治疗的 III 期研究
- 批准号:
6307461 - 财政年份:1999
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6308043 - 财政年份:1999
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6297861 - 财政年份:1998
- 资助金额:
$ 10万 - 项目类别:
LRF ANALOG TO DELAY PUBERTY IN PRECOCIOUS PUBERTY, GH DEFICIENCY, SHORT STATURE
LRF 类似物可延迟性早熟、生长激素缺乏、身材矮小患者的青春期
- 批准号:
6220124 - 财政年份:1998
- 资助金额:
$ 10万 - 项目类别: