COMPLETION OF DATA HARMONIZATION IN PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS (PATC3H) PROGRAM

通过资源有限环境中受艾滋病毒影响的青少年的全面护理连续体 (PATC3H) 计划完成预防和治疗方面的数据协调

• 批准号: 10887928
• 负责人: Barbara Driver
• 金额: $ 47.38万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10887928
• 关键词: Achievement; Acquired Immunodeficiency Syndrome; Adolescent; Affect; Africa South of the Sahara; Age; Award; Brazil; Caring; Childhood; Clinic; Clinical Research; Collaborations; Common Data Element; Communicable Diseases; Communities; Comprehensive Health Care; Continuity of Patient Care; Contracts; Country; Data; Data Analyses; Data Set; Education; Family; Funding; Goals; HIV; HIV Infections; Health; Health system; Incidence; Income; Individual; Intervention; Link; National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Outcome; Phase; Policies; Prevention; Protocols documentation; Public Health; Recommendation; Research; Research Personnel; Resource Sharing; Resource-limited setting; Risk; Specimen; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; Youth; behavioral and social science; data harmonization; data interoperability; data sharing; data structure; efficacious intervention; improved; innovation; programs; public health intervention; research clinical testing; social science research; working group

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support to complete data harmonization activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) Program. Harmonization of common data elements will facilitate data sharing and analysis across PATC3H programs. The NICHD and partner NIH Institutes have funded eight PATC3H awards in Brazil and sub-Saharan Africa since 2018 through a phased innovation cooperative agreement mechanism for interventions of high public health significance: prevention of new HIV infections among adolescents at risk and identification of youth living with HIV in low-to-middle income countries with high HIV burden, linking them to and retaining them in care, and achieving long-term viral suppression. PATC3H investigators are evaluating a variety of innovative combination interventions aimed at several levels, including individual, family, clinic, community, structural, and education and health systems. Projects include collaborations with local agencies and regulatory bodies, including policy and program leaders, to advance achievement of the research objectives, and to maximize implementation and sustainability of efficacious interventions and best practices. Creating interoperability of datasets generated by these projects requires data harmonization after study completion across PATC3H programs.

尤尼斯·肯尼迪·施赖弗国家儿童健康和人类发展研究所 (NICHD) 需要支持，通过资源有限环境中受艾滋病毒影响的青少年综合护理连续体 (PATC3H) 计划完成预防和治疗的数据协调活动。通用数据元素的协调将促进 PATC3H 项目之间的数据共享和分析。 自 2018 年以来，NICHD 和合作伙伴 NIH 研究所已通过分阶段创新合作协议机制，在巴西和撒哈拉以南非洲地区资助了 8 个 PATC3H 奖项，用于具有高度公共卫生意义的干预措施：在高危青少年中预防新的艾滋病毒感染，在艾滋病毒负担高的中低收入国家识别感染艾滋病毒的青年，将他们与他们联系起来并让他们接受护理，并实现长期目标 病毒抑制。 PATC3H 研究人员正在评估针对多个层面的各种创新组合干预措施，包括个人、家庭、诊所、社区、结构以及教育和卫生系统。项目包括与当地机构和监管机构（包括政策和项目领导者）合作，以促进研究目标的实现，并最大限度地提高有效干预措施和最佳实践的实施和可持续性。创建这些项目生成的数据集的互操作性需要在 PATC3H 项目的研究完成后进行数据协调。