COMPLETION OF DATA HARMONIZATION IN PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS (PATC3H) PROGRAM

通过资源有限环境中受艾滋病毒影响的青少年的全面护理连续体 (PATC3H) 计划完成预防和治疗方面的数据协调

• 批准号: 10887928
• 负责人: Barbara Driver
• 金额: $ 47.38万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10887928
• 关键词: Achievement; Acquired Immunodeficiency Syndrome; Adolescent; Affect; Africa South of the Sahara; Age; Award; Brazil; Caring; Childhood; Clinic; Clinical Research; Collaborations; Common Data Element; Communicable Diseases; Communities; Comprehensive Health Care; Continuity of Patient Care; Contracts; Country; Data; Data Analyses; Data Set; Education; Family; Funding; Goals; HIV; HIV Infections; Health; Health system; Incidence; Income; Individual; Intervention; Link; National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Outcome; Phase; Policies; Prevention; Protocols documentation; Public Health; Recommendation; Research; Research Personnel; Resource Sharing; Resource-limited setting; Risk; Specimen; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; Youth; behavioral and social science; data harmonization; data interoperability; data sharing; data structure; efficacious intervention; improved; innovation; programs; public health intervention; research clinical testing; social science research; working group

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support to complete data harmonization activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) Program. Harmonization of common data elements will facilitate data sharing and analysis across PATC3H programs. The NICHD and partner NIH Institutes have funded eight PATC3H awards in Brazil and sub-Saharan Africa since 2018 through a phased innovation cooperative agreement mechanism for interventions of high public health significance: prevention of new HIV infections among adolescents at risk and identification of youth living with HIV in low-to-middle income countries with high HIV burden, linking them to and retaining them in care, and achieving long-term viral suppression. PATC3H investigators are evaluating a variety of innovative combination interventions aimed at several levels, including individual, family, clinic, community, structural, and education and health systems. Projects include collaborations with local agencies and regulatory bodies, including policy and program leaders, to advance achievement of the research objectives, and to maximize implementation and sustainability of efficacious interventions and best practices. Creating interoperability of datasets generated by these projects requires data harmonization after study completion across PATC3H programs.

尤尼斯·肯尼迪·施莱弗国家儿童健康和人类发展研究所(NICHD)要求提供支持，以通过资源受限环境中受艾滋病毒影响的青少年综合护理连续体(PATC3H)方案完成预防和治疗数据协调活动。统一通用数据元素将促进PATC3H方案之间的数据共享和分析。 自2018年以来，NICHD和合作伙伴NIH研究所通过阶段性创新合作协议机制为巴西和撒哈拉以南非洲地区的八个PATC3H奖项提供了资金，这些合作协议机制用于具有高度公共卫生意义的干预措施：预防高危青少年中的新艾滋病毒感染，在艾滋病毒负担较高的中低收入国家识别感染艾滋病毒的青年，将他们与艾滋病毒高负担国家的艾滋病毒携带者联系起来并将他们保留在护理中，并实现长期病毒抑制。PATC3H调查人员正在评估针对几个层面的各种创新的组合干预措施，包括个人、家庭、诊所、社区、结构以及教育和卫生系统。项目包括与当地机构和监管机构(包括政策和项目负责人)的合作，以促进研究目标的实现，并最大限度地实施和持续有效的干预措施和最佳实践。创建由这些项目生成的数据集的互操作性需要在PATC3H项目的研究完成后进行数据协调。