Modulation of gut Clostridia by Trichuris muris

鼠鞭虫对肠道梭菌的调节

• 批准号: 10886842
• 负责人: Anna Maria Seekatz
• 金额: $ 18.68万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10886842
• 关键词: Area; Autoimmune Diseases; Centers of Research Excellence; Exposure to; Goals; Health; Helminths; Hygiene; Individual; Infection; Inflammatory Bowel Diseases; Prevalence; Research; Soil; Therapeutic Intervention; Trichuris; helminth infection; host microbiota; innovation; microbial; novel; pathogen; transmission process

There is a critical need to understand factors impacting transmission and infection caused by the soil-dwelling helminth Trichuris trichia, or whipworm, which infects over half a billion individuals per year globally. Paradoxically, decreased exposure to helminths due to increased hygiene practices is also implicated in increased prevalence of autoimmune conditions such as Inflammatory Bowel Disease, which are negatively associated with areas with endemic helminth infections. As such, disentangling gut host-microbiota interactions is a key objective for advancing novel microbial therapeutics interventions for the benefit of hose health, which is one of our long-term research goals.

迫切需要了解影响土壤寄生蠕虫鞭虫或鞭虫传播和感染的因素，这种蠕虫每年感染全球5亿多人。矛盾的是，由于更多的卫生做法而减少了对蠕虫的接触，这也与自身免疫性疾病(如炎症性肠病)的流行有关，这些疾病与地方性蠕虫感染的地区呈负相关。因此，解开肠道宿主-微生物区系的相互作用是推进新型微生物疗法干预措施的关键目标，以造福于软管健康，这是我们的长期研究目标之一。