Advanced Development of a Vaccine for Acute Flaccid Myelitis Associated with Enterovirus D68

支持候选产品的高级开发，用于故意释放或应对由NIAID A、B和C类优先病原体或新发传染病引起的传染病自然暴发。该合同可支持单个疫苗组分的配制和生产，以及动物模型中的稳定性试验、非临床免疫原性和有效性试验、IND启用GLP毒理学、IND提交以及临床安全性和有效性评价。该项目的重点是为儿童群体开发急性弛缓性肌麻痹疫苗。

To support the advanced development of candidate products for use following the intentional release of or in response to naturally occurring outbreaks of infectious diseases caused by NIAID Category A, B, and C Priority Pathogens or emerging infectious diseases. This contract may support formulation and manufacture of the individual vaccine components, as well as stability testing, nonclinical immunogenicity and efficacy testing in animal models, IND enabling GLP toxicology, submission of an IND and clinical safety and efficacy evaluation. This project focuses on the development of an Acute Flaccid Myelitis vaccine for pediatric populations.