Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's

项目总结/摘要 老年人，特别是帕金森病（PD）患者，可能会遇到行走困难， 对他们的日常功能和生活质量产生负面影响。这个项目将研究音乐的影响， 在步行表演中唱歌，目的是了解什么类型的节奏线索最有助于 帕金森病患者和老年人。我们的试点工作表明，想象中的，精神上的歌唱， 步行可以帮助人们走得更快，更稳定，而随着音乐走路也可以帮助人们走得更快 但稳定性降低。在目标1中，我们将比较边走边唱歌和边走边听音乐。 音乐，使用个性化的线索量身定制每个人的步行性能。我们还将测试手指是否 敲击，一种有节奏的任务，在许多方面类似于走路，在精神上唱歌时也有类似的反应， 听音乐在目标2中，我们将研究增强的大脑机制， 通过心灵歌唱或音乐聆听看到的运动表现。我们将使用磁共振成像 (MRI)在有和没有各种线索的情况下测量手指敲击时的大脑活动， 对不同类型的线索或多或少有反应。利用前两个实验中获得的信息 目的，然后我们将在目的3中进行干预研究，比较和对比基于音乐的效果 vs.为PD患者提供基于歌唱的培训。我们将确定哪种训练方法效果最好 步行和敲击性能的改善，并测量训练中大脑活动的变化。我们将 还要询问学员不同培训方法的可接受性和可用性。这项工作是其中 第一个专注于唱歌作为改善PD行走的干预措施，并且在使用方面具有创新性 一种新颖的、未开发的、高度可及的、适应性强的、低成本的方法，它有可能增强步行， 从而改善PD患者的日常功能和生活质量。

PROJECT SUMMARY/ABSTRACT Older adults, and particularly those with Parkinson disease (PD), may experience walking difficulties that negatively impact their daily function and quality of life. This project will examine the impact of music and singing on walking performance, with the goal of understanding what types of rhythmic cues are most helpful to people with Parkinson disease and older adults. Our pilot work suggests that imagined, mental singing while walking helps people walk faster with greater stability, whereas walking to music also helps people walk faster but with reduced stability. In Aim 1, we will compare walking while mentally singing to walking while listening to music, using personalized cues tailored to each person's walking performance. We will also test whether finger tapping, a rhythmic task similar to walking in many ways, responds similarly while mentally singing and listening to music. In Aim 2, we will investigate the brain mechanisms underlying the enhancements in movement performance seen with mental singing or music listening. We will use magnetic resonance imaging (MRI) to measure brain activity during finger tapping with and without various cues to understand which areas of the brain are more or less responsive to different types of cues. Using the information gained in the first two aims, we will then conduct an intervention study in Aim 3 to compare and contrast the effects of music-based vs. singing-based training for people with PD. We will determine which training method results in the greatest improvements in walking and tapping performance and measure changes in brain activity with training. We will also ask the participants how acceptable and usable the different training approaches are. This work is among the first to focus on singing as an intervention to improve walking in PD and is innovative in its use of this novel, untapped, highly accessible, adaptable, low-cost approach that has the potential to enhance walking, thereby improving everyday function and quality of life for people with PD.