Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's

项目摘要/摘要 老年人，特别是患有帕金森病(PD)的人，可能会经历行走困难 对他们的日常功能和生活质量产生负面影响。这个项目将考察音乐和音乐的影响 在步行表演中唱歌，目的是了解什么类型的节奏提示最有助于 帕金森病患者和老年人。我们的试点工作表明，想象中的、心理上的歌唱 走路有助于人们走得更快更稳定，而随着音乐散步也能帮助人们走得更快 但稳定性降低了。在目标1中，我们将比较在头脑中唱歌时走路和在听歌时走路 音乐，使用为每个人的行走表演量身定做的个性化提示。我们还将测试手指是否 敲击，一种在许多方面类似于行走的有节奏的任务，在大脑中唱歌和 听音乐。在目标2中，我们将研究增强的大脑机制。 在精神上唱歌或听音乐时看到的动作表演。我们将使用磁共振成像 (MRI)在有和没有各种线索的情况下测量手指敲击时的大脑活动，以了解哪些区域 大脑的不同部分或多或少对不同类型的线索做出反应。使用在前两个步骤中获得的信息 ，然后我们将在目标3中进行一项干预研究，以比较和对比基于音乐的效果 与以唱歌为基础的帕金森病患者培训。我们将确定哪种训练方法的效果最好 改善行走和敲击能力，并通过训练测量大脑活动的变化。我们会 还要询问学员对不同培训方法的接受度和可用性。这项工作是其中之一 第一个将唱歌作为改善帕金森病患者行走的干预措施，并在此方面进行了创新 新的、未开发的、高度可访问的、适应性强的、低成本的方法，有可能增强步行能力， 从而改善帕金森病患者的日常功能和生活质量。

PROJECT SUMMARY/ABSTRACT Older adults, and particularly those with Parkinson disease (PD), may experience walking difficulties that negatively impact their daily function and quality of life. This project will examine the impact of music and singing on walking performance, with the goal of understanding what types of rhythmic cues are most helpful to people with Parkinson disease and older adults. Our pilot work suggests that imagined, mental singing while walking helps people walk faster with greater stability, whereas walking to music also helps people walk faster but with reduced stability. In Aim 1, we will compare walking while mentally singing to walking while listening to music, using personalized cues tailored to each person's walking performance. We will also test whether finger tapping, a rhythmic task similar to walking in many ways, responds similarly while mentally singing and listening to music. In Aim 2, we will investigate the brain mechanisms underlying the enhancements in movement performance seen with mental singing or music listening. We will use magnetic resonance imaging (MRI) to measure brain activity during finger tapping with and without various cues to understand which areas of the brain are more or less responsive to different types of cues. Using the information gained in the first two aims, we will then conduct an intervention study in Aim 3 to compare and contrast the effects of music-based vs. singing-based training for people with PD. We will determine which training method results in the greatest improvements in walking and tapping performance and measure changes in brain activity with training. We will also ask the participants how acceptable and usable the different training approaches are. This work is among the first to focus on singing as an intervention to improve walking in PD and is innovative in its use of this novel, untapped, highly accessible, adaptable, low-cost approach that has the potential to enhance walking, thereby improving everyday function and quality of life for people with PD.