Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's

项目概要/摘要 老年人，尤其是患有帕金森病 (PD) 的老年人，可能会遇到行走困难， 对他们的日常功能和生活质量产生负面影响。该项目将研究音乐和音乐的影响 在步行表演中唱歌，目的是了解哪些类型的节奏提示最有帮助 患有帕金森病的人和老年人。我们的试点工作表明，想象的、心理的歌唱 步行可以帮助人们走得更快、更稳定，而随着音乐步行也可以帮助人们走得更快 但稳定性降低。在目标 1 中，我们将边唱歌边走路与边听歌边走路进行比较 音乐，使用针对每个人的步行表现量身定制的个性化提示。我们还将测试手指是否 敲击是一种在很多方面类似于行走的有节奏的任务，在精神上唱歌时的反应类似 听音乐。在目标 2 中，我们将研究增强大脑功能的大脑机制。 通过心理歌唱或音乐聆听看到的动作表现。我们将使用磁共振成像 （MRI）测量手指敲击时的大脑活动，有或没有各种提示，以了解哪些区域 大脑的不同部分或多或少对不同类型的提示做出反应。利用前两次获得的信息 目标，然后我们将在目标 3 中进行干预研究，以比较和对比基于音乐的效果 与针对帕金森病患者的歌唱训练相比。我们将确定哪种训练方法效果最好 改善步行和敲击性能，并通过训练测量大脑活动的变化。我们会 还询问参与者不同培训方法的可接受性和可用性。这部作品属于 第一个专注于通过唱歌作为改善帕金森病步行的干预措施，并且在使用这一点方面具有创新性 新颖的、尚未开发的、高度可及的、适应性强的、低成本的方法，有潜力增强步行能力， 从而改善帕金森病患者的日常功能和生活质量。

PROJECT SUMMARY/ABSTRACT Older adults, and particularly those with Parkinson disease (PD), may experience walking difficulties that negatively impact their daily function and quality of life. This project will examine the impact of music and singing on walking performance, with the goal of understanding what types of rhythmic cues are most helpful to people with Parkinson disease and older adults. Our pilot work suggests that imagined, mental singing while walking helps people walk faster with greater stability, whereas walking to music also helps people walk faster but with reduced stability. In Aim 1, we will compare walking while mentally singing to walking while listening to music, using personalized cues tailored to each person's walking performance. We will also test whether finger tapping, a rhythmic task similar to walking in many ways, responds similarly while mentally singing and listening to music. In Aim 2, we will investigate the brain mechanisms underlying the enhancements in movement performance seen with mental singing or music listening. We will use magnetic resonance imaging (MRI) to measure brain activity during finger tapping with and without various cues to understand which areas of the brain are more or less responsive to different types of cues. Using the information gained in the first two aims, we will then conduct an intervention study in Aim 3 to compare and contrast the effects of music-based vs. singing-based training for people with PD. We will determine which training method results in the greatest improvements in walking and tapping performance and measure changes in brain activity with training. We will also ask the participants how acceptable and usable the different training approaches are. This work is among the first to focus on singing as an intervention to improve walking in PD and is innovative in its use of this novel, untapped, highly accessible, adaptable, low-cost approach that has the potential to enhance walking, thereby improving everyday function and quality of life for people with PD.