NEW PATHWAYS TO NITROGEN HETEROCYCLES

氮杂环的新途径

• 批准号: 2024444
• 负责人: Ihsan Erden
• 金额: $ 9.47万
• 依托单位: SAN FRANCISCO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2024444
• 关键词: chemical addition; chemical condensation; chemical synthesis; nitrogenous heterocyclic compound

DESCRIPTION: A new method of the synthesis of nitrogen heterocycles based on tandem Michael addition-Dieckmann condensation is proposed. This synthesis strategy, called by the PI aza-Robinson annulation, will provide suitably functionalized 5-membered heterocycles, which could be used as intermediates in the synthesis of more advanced precursors of alkaloids and other physiologically active compounds.

描述：一种合成含氮杂环化合物的新方法 提出了串联Michael加成-Dieckmann凝聚的概念。这 被称为Pi Aza-Robinson环的合成策略将提供 适当官能化的5元杂环，可用作 合成更高级生物碱和生物碱前体的中间体 其他具有生理活性的化合物。