PCA PROGRESSION AND METASTASIS

作为对NIH RFA CA-95-006的回应，密歇根癌症基金会 底特律大都会迈耶·L·普伦蒂斯综合癌症中心 (MLPCCCMD)建议在泌尿外科肿瘤学内开发一个独特的项目 与前列腺癌(PCA)的主要重点将结合 实验室、临床研究、流行病学和最终的行为学 研究项目。这项提议的具体目标是建立一个 使用翻译和临床科学家的工作组与集体 在前列腺癌生物检测、筛查和最终治疗方面的专业知识， 实施一系列试点项目，以获得初步数据 这将使拟议的研究比传统的RO1更具竞争力 和PO1资金。最后，把研究成果转化为有用的 诊断、预后和治疗发展的策略 来自PCA的策略。作为该计划的一部分，8名新教师专门 在PCA研究中，将招募翻译和基本一级的研究人员 韦恩州立大学(WSU)。还提供了实验室空间 作为比较基因组杂交分析(CGH)的核心设备。 一笔可观的大学拨款511万美元，超过 已承诺4年作为这笔发展赠款的等额资金。 这笔资金包括8名个人的工资(256万美元)， 大学校长的承付款(150万美元)，a 5个参与部门的承担额(100万美元)和一个 承诺为CGH核心设施提供50%匹配(50,000美元)。一个核心的 将成立基础科学和翻译研究调查员 围绕模型系统、预测指标、 肿瘤抑制基因、细胞信号机制、细胞凋亡和运动 和入侵。这项提案的一个特别强调是对 美国的非洲裔美国人和高加索人 底特律大都会地区检测生物因素负责 在这两个人群中，在PCA中观察到的种族差异。 已选定四个试点项目作为初始资金，它们是 非洲人前列腺上皮细胞系的建立 美国和高加索患者的基因组改变和 非裔美国人前列腺癌中细胞增殖的研究 非洲人前列腺癌前病变的种族视角 美国人和高加索人，以及综合信息管理系统 用于PCA数据。后者将是对当前 MLPCCCMD的生物统计学核心。它将包括一个电子链接 现有的五个数据库以及引入 调查员将数据输入到这个集成系统中。最终目标 这一倡议的关键是将发现从基础科学领域转移到 尽快在临床上应用PCa。

In response to NIH RFA CA-95-006 the Michigan Cancer Foundation operating the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit (MLPCCCMD) proposed to develop within Urologic Oncology a distinct program with a major emphasis in Prostate Cancer (PCa) that will combine laboratory, clinical research, epidemiological and ultimately behavioral research programs. The specific aims of this proposal are to establish a working group using translational and clinical scientists with collective expertise in PCa biology detection, screening and ultimately treatment, To implement a series of pilot projects that will garner preliminary data which will make the proposed research more competitive for traditional RO1 and PO1 funding. Finally to translate research results into useful strategies form diagnosis prognosis and development of treatment strategies from PCa. As part of this program 8 new faculty specializing in PCa research at the translational and basic level will be recruited to Wayne State University (WSU). Laboratory space has been provided as well as a core facility in comparative genomic hybridization analysis (CGH). A substantial university commitment in the amount of $5. 11 million over 4 years has been pledged as matching money to this development grant. This funding includes salary for 8 individuals ($2.56 million), a commitment from the President of the university ($1.5 million), a commitment from 5 participating departments ($1.0 million) and a commitment for 50% match for the CGH Core Facility ($50,000). A core of basic science and translational research investigators will be formed around the interactive themes of model systems, prognostic indicators, tumor suppressor genes, cell signalling mechanisms, apoptosis and motility and invasion. A particular emphasis of this proposal is an examination of the African-American population and the Caucasian population in the Detroit Metropolitan area to test for biological factors responsible for the racial differences observed in PCa within these two population groups. Four pilot projects have been chosen for initial funding and they are the establishment of human prostate epithelial cell lines from African American and Caucasian patient examination of genomic alternations and cellular proliferation in PCa of African Americans, the study on the racial perspectives on premalignant lesions of the prostate in African- Americans and Caucasians, and an integrated information management system for PCa data. The latter will be an enhancement of the current biostatistics core of the MLPCCCMD. It will include an electronic link of five currently existing databases as well as the introduction of investigator initiated data into this integrated system. The final goal of this initiative is to move discoveries from the basic science arena to clinical applications for Pca as rapidly as possible.