LEPTIN AND HEMATOPOIESIS

瘦素和造血作用

• 批准号: 2332572
• 负责人: Donald Rao
• 金额: $ 10万
• 依托单位: ICOGENEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2332572
• 关键词: RNA splicing; bone marrow; cell type; cytokine; hematopoiesis; hematopoietic stem cells; histochemistry /cytochemistry; immunofluorescence technique; in situ hybridization; laboratory mouse; obesity; protein structure function; receptor expression; single cell analysis; tissue /cell culture; transplantation

DESCRIPTION: (Adapted from the Applicant's Abstract): The goal of this project is to develop therapeutic applications for leptin in treatment of hematopoietic diseases and transplantation. Recently they have found that leptin affects the survival and expansion of a population of bone marrow cells. A thorough characterization of the effect of leptin on fractionated bone marrow cells will be performed. The lineage of leptin specific target cells will be further delineated and the functional role of leptin in hematopoiesis will be investigated. Information obtained from this Phase 1 research will indicate the feasability of utilizing leptin as a therpeutic agent for the ex vivo expansion of trasnplantable progenitor cells and in vivo to accelerate recovery after transplantation.

描述：(改编自申请者摘要)：目标 这个项目是为了开发瘦素的治疗应用 血液病的治疗和移植。最近他们 研究发现，瘦素影响小鼠的生存和扩张 骨髓细胞的数量。对《红楼梦》的全面描述 瘦素对分离的骨髓细胞的影响将被执行。 瘦素特异性靶细胞的谱系将进一步 瘦素在造血意志中的作用及其功能 被调查。从第一阶段研究中获得的信息将 说明利用瘦素作为治疗药物的可行性 用于可移植祖细胞的体外扩增和体内扩增 以加速移植后的恢复。