ETHANE EXHALATION AS AN INDEX OF NEUROLOGICAL STRESS
乙烷呼出量作为神经应激指标
基本信息
- 批准号:2018883
- 负责人:
- 金额:$ 9.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 1998-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from Investigator's Abstract): The importance of
anti-oxidant defenses in the maintenance of general well-being and optimal
health is becoming increasingly recognized both among health specialists
and also among the general public. Furthermore, elevated levels of free
radical generation and consequent oxidative damage to macromolecules,
have been implicated in an increasing number of progressive neurological
disoders such as Alzheimer's disease (AD), Parkinsons disease (PD),
amyotrophic lateral sclerosis, multiple sclerosis and epilepsy.
Antioxidant therapy is being tested experimentally for all the above
diseases. Antioxidant utilization has also been proposed as a possible
means of reducing the very high incidence of colon cancer in the United
States. The use of antioxidants may be of especial value to certain high
risk segments of the population such as smokers. Taken together, these
issues suggest that this is an appropriate time to promote the
development of a convenient means of quantitating the parameter of total
bodily oxidant status. This application plans to develop an inexpensive,
portable, compact and easily usable chromatographic kit to allow a rapid
and accurate quantitative analysis of expired ethane. The measurement of
exhaled hydrocarbon gases constitutes a totally non-invasive means of
estimating oxidative stress in living organisims.
PROPOSED COMMERCIAL APPLICATION:
This project has a very high commercial potential. The device/product can
find applications in wide ranging areas from medical and clinical
diagnostics to health centers,spas and doctors' offices.
描述(改编自研究者摘要):
抗氧化防御在维护一般福祉和最佳
健康越来越受到健康专家和
也在公众中。 此外,自由基水平升高
自由基的产生和随之而来的对大分子的氧化损伤,
与越来越多的进行性神经系统疾病有关
疾病如阿尔茨海默病(AD),帕金森病(PD),
肌萎缩侧索硬化症、多发性硬化症和癫痫症。
抗氧化疗法正在对上述所有情况进行实验测试
疾病 抗氧化剂的利用也被认为是一种可能的方法。
结肠癌的发病率很高,
States. 抗氧化剂的使用可能对某些高
吸烟者等高危人群。 综上所述各项
问题表明,这是一个适当的时间来促进
开发了一种方便的方法来定量总参数,
身体氧化状态 该应用程序计划开发一种廉价的,
便携、紧凑和易于使用的色谱试剂盒,
准确定量分析过期乙烷。 的测量
呼出的碳氢化合物气体构成了一种完全非侵入性的手段,
评估生物体内的氧化应激。
拟定商业应用:
该项目具有很高的商业潜力。 设备/产品可以
在医疗和临床等广泛领域得到应用
诊断到保健中心、水疗中心和医生办公室。
项目成果
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