MECHANISMS OF CLOTTING FACTOR VIII IMMUNOGENICITY

凝血因子 VIII 免疫原性的机制

• 批准号: 2229490
• 负责人: DEBRA NEWTON-NASH
• 金额: $ 10.49万
• 依托单位: VERSITI WISCONSIN, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2229490
• 关键词: CD antigens; MHC class II antigen; T cell receptor; T lymphocyte; alleles; antibody formation; cellular immunity; clone cells; coagulation factor VIII; enzyme linked immunosorbent assay; helper T lymphocyte; hemophilia As; histocompatibility typing; human subject; immunoglobulin isotypes; interleukin 2; interleukin 4; interleukin 5; protein sequence; synthetic peptide

This investigator will study the production of antibodies that inhibit Factor VIII procoagulant function, particularly with regard to regulation by Factor VIII-specific T cells. These inhibitors provide a substantial cause of morbidity for the hemophiliac, and are responsible for the requirement of these individuals for large amounts of blood products including Factor IX which still is responsible for transmission of viral infections. In addition, coagulation concentrates are responsible and may be related to substantial changes in the immune system seen in HIV positive and negative hemophiliacs. This group will study Factor VIII dependent T cell proliferation, cytokine production and expression of activation markers.

这位研究者将研究抗体的产生， 因子VIII促凝血功能，特别是调节 通过VIII因子特异性T细胞。 这些抑制剂提供了实质性的 血友病的发病原因，并负责 这些人对大量血液制品的需求 包括仍然负责病毒传播的因子IX 感染. 此外，混凝浓缩物是负责的， 可能与HIV感染者免疫系统的实质性变化有关 阳性和阴性血友病患者 这个小组将研究第八因子 依赖性T细胞增殖、细胞因子产生和 激活标记。