Mechanisms of Head and Neck Cancer Progression Role of Matrix Metallopreinase (MMP-2) Using in vitro and in vivo Anima

这项提议将有助于改善人类健康、生活质量和患者寿命。头颈部癌在澳大利亚和中国是高发地区。癌症患者往往在疾病晚期转移到邻近和远处的器官，包括骨骼，遭受疼痛、面神经瘫痪、复发，并经常在非常令人痛苦的情况下死亡。这项建议旨在阐明头颈部癌症的分子机制，并帮助提出更好的癌症治疗方法，包括为癌症基因治疗提供新的靶点。

This proposal will assist in improving human health, quality of life and patient lifespan. Head and Neck cancer is of high prevalence in Australia and China. Cancer patients, often with metastasis to adjacent and distant organs, including bone at late stages of the disease, suffer from pain, facial nerve paralysis, recurrence and frequently die under very distressing circumstances. This proposal intends to elucidate the molecular mechanism of Head and Neck cancer and help come up with better treatments against cancers including providing a new target for cancer gene therapy.