NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
批准号:
6798540
负责人:
P. Michael Conneally
金额:
$12.5万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-07-15 至 2006-06-30
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): The National Cell Repository (NCR) was established over a decade ago to collect and maintain information and biological specimens on large numbers of genetically informative, phenotypically well-characterized families with multiple individuals affected with Alzheimer Disease (AD). These families have been successfully used to study the genetics of AD. Over the past decade there has been keen interest to identify the genes contributing to late onset (onset 60 years) AD (LOAD). To date, the important role of apolipoprotein E (APOE) has been delineated in families with LOAD. Clearly, other genes also contribute to late onset AD susceptibility. This supplemental application proposes to provide the resources critical to AD researchers that will allow the elucidation of LOAD susceptibility genes. To this end, the following specific aims are addressed in this supplemental application:
1) Ensure a resource of multiplex LOAD families recruited through Alzheimer Disease Centers (ADCs).
a) Establish immortalized cell lines from all genetically informative family members.
b) Assist ADCs to maintain contact with families to identify additional affected individuals and plan
autopsies.
2) Establish a case control cohort recruited through the AIzheimer Disease Centers (ADCs).
a) Isolate DNA from brain sections of LOAD cases previously ascertained through the ADCs.
b) Establish immortalized cell lines from living cases and controls ascertained through the ADCs.
3) Obtain additional clinical data from previously recruited LOAD families already participating in the NCR.
a) Complete telephone cognitive evaluation of all individuals over the age of 50 years.
b) Obtain additional clinical information from informants regarding symptom progression of LOAD
subjects.
4) Develop and maintain an internet resource (web page) to review available NCR resources.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CORE--NATIONAL CELL REPOSITORY
-
批准号:6652173
-
项目类别:
-
资助金额:$17.85万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
NATIONAL CELL REPOSITORY FOR ALZHEIMER'S DISEASE
-
批准号:6594200
-
项目类别:
-
资助金额:$38.02万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6668204
-
项目类别:
-
资助金额:$17.85万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6563288
-
项目类别:
-
资助金额:$17.85万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
National Cell Repository for Alzheimers's Disease
-
批准号:6616645
-
项目类别:
-
资助金额:$40.0万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6616291
-
项目类别:
-
资助金额:$17.85万
-
财政年份:2002
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6324514
-
项目类别:
-
资助金额:$23.7万
-
财政年份:2000
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6216999
-
项目类别:
-
资助金额:$23.7万
-
财政年份:1999
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6098339
-
项目类别:
-
资助金额:$23.7万
-
财政年份:1999
-
负责人:P. Michael Conneally
-
依托单位:
PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
-
批准号:6187115
-
项目类别:
-
资助金额:$127.49万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
-
批准号:2696740
-
项目类别:
-
资助金额:$112.04万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
NATIONAL RESEARCH ROSTER FOR HUNTINGTON DISEASE PATIENTS
-
批准号:2858295
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
NATIONAL RESEARCH ROSTER FOR HUNTINGTON DISEASE PATIENTS
-
批准号:6152300
-
项目类别:
-
资助金额:$31.29万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6295555
-
项目类别:
-
资助金额:$24.5万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
NATIONAL RESEARCH ROSTER FOR HUNTINGTON DISEASE PATIENTS
-
批准号:2879757
-
项目类别:
-
资助金额:$30.19万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
NATIONAL RESEARCH ROSTER FOR HUNTINGTON DISEASE PATIENTS
-
批准号:2834339
-
项目类别:
-
资助金额:$30.01万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
-
批准号:6317926
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
-
批准号:2892380
-
项目类别:
-
资助金额:$124.45万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6267532
-
项目类别:
-
资助金额:$24.5万
-
财政年份:1998
-
负责人:P. Michael Conneally
-
依托单位:
CORE--NATIONAL CELL REPOSITORY
-
批准号:6234315
-
项目类别:
-
资助金额:$22.69万
-
财政年份:1997
-
负责人:P. Michael Conneally
-
依托单位:
国内基金
海外基金
登录
查看更多内容
自供能传感阵列同步量化游离DNA与PSA实现前列腺癌的诊断和预后判断
-
批准号:JCZRLH202601177
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
二氢杨梅素通过线粒体代谢重编程抑制DNA同源重组修复逆转口腔癌细胞放疗抵抗的机制研究
-
批准号:2026JJ80500
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:阳帆
-
依托单位:
乳酸通过ESM1-Akt-MDM2-p53通路调控卵巢癌DNA损伤和抗肿瘤免疫应答的分子机制研究
-
批准号:2026JJ81975
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:肖娇
-
依托单位:
淫羊藿苷通过TET2介导DNA去甲基化调控Hippo-YAP/TAZ通路逆转绝经后骨质疏松症成血管-成骨耦联失衡的机制研究
-
批准号:2026JJ82371
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:王哲享
-
依托单位:
CDC45通过调控DNA复制应激促进肝癌发生发展的机制
-
批准号:2026JJ82714
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:赵志坚
-
依托单位:
PCV2茎环结构DNA激活cGAS-STING通路诱导的天然免疫应答的作用研究
-
批准号:2026JJ50413
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:王东亮
-
依托单位:
机械力响应型DNA探针用于肿瘤微环境细胞力学可视化与药物筛选研究
-
批准号:2026JJ60135
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:杨思慧
-
依托单位:
基于孕妇外周血游离DNA靶向捕获测序筛查胎儿隐性单基因病的探索研究
-
批准号:JCZRLH202600067
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
WSTF/SNF2H 介导的 DNA 损伤在 DPSCs 衰老中的机制研究
-
批准号:ZCLQN26H1401
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:虞其豪
-
依托单位:
孕期多环芳烃暴露与DNA甲基化改变对子代神经发育影响的出生队列研究
-
批准号:2026JJ81844
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:吕玲双
-
依托单位: